11 recruiting, 5 completed, 4 not yet recruiting, 2 enrolling by invitation. 22 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 22 | Recruiting 11, Completed 5, Not yet recruiting 4, Enrolling by invitation 2 |
Follow Temporal Interference Stimulation: new trials by email Literature Review of Temporal Interference Stimulation trials Research Report on Temporal Interference Stimulation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring Temporal Interference Stimulation, Direct Electrical Stimulation - Drug-Resistant Focal Epilepsy | Not applicable | Recruiting | Duke University | 30 | 2026-09-16 | 2026-10-15 |
| Closed-loop tTIS Targeted of the Nac as an Intervention for MUD Patients Temporal Interference Stimulation, Shame - Amphetamine Use Disorders | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 50 | 2026-09-01 | 2026-09-03 |
| Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing SEEG Monitoring Temporal Interference Stimulation - Epilepsy | Not applicable | Not yet recruiting | Beijing Sanbo Brain Hospital | 60 | 2026-08-30 | 2026-08-27 |
| Efficacy and Safety of Temporal Interference Stimulation in Treatment-Resistant Schizophrenia: An Exploratory Study. Temporal Interference Stimulation - Treatment-resistant Schizophrenia | Not applicable | Not yet recruiting | Zhimin Wang | 20 | 2026-08-01 | 2026-08-19 |
| Hippocampal Temporal Interference Stimulation for Memory and Dual-Task Postural Control in Older Adults With Mild Cognitive Impairment Temporal Interference Stimulation - Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Shanghai University of Sport | 21 | 2026-07-30 | 2026-08-18 |
| Different Frequency Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease Temporal Interference Stimulation - Parkinson Disease (PD) | Not applicable | Recruiting | Ke Dong, MD | 40 | 2026-07-20 | 2026-08-11 |
| Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment Temporal Interference Stimulation, Sham Temporal Interference Stimulation, Targeted Cognitive Training - Amnestic Mild Cognitive Impairment - aMCI, AD-MCI | Not applicable | Recruiting | Tianjin Huanhu Hospital | 60 | 2026-07-01 | 2026-06-11 |
| dACC-Targeted Temporal Interference for Negative and Cognitive Symptoms in Schizophrenia Temporal Interference Stimulation, Sham Temporal Interference Stimulation - Schizophrenia Disorder | Not applicable | Recruiting | Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University | 74 | 2026-06-30 | 2026-08-21 |
| TIS for Improving Cognitive Impairment in Schizophrenia temporal interference stimulation, Sham stimulation - Schizophrenia Disorder, Cognitive Impairments | Not applicable | Recruiting | Central South University | 50 | 2026-06-24 | 2026-07-17 |
| TIS for Improving Cognitive Impairment Associated With Schizophrenia temporal interference stimulation - Cognitive Impairment Associated With Schizophrenia (CIAS) | Not applicable | Completed | Central South University | 10 | 2026-06-24 | 2026-09-23 |
| Effect and Safety of Non-invasive Electrical Stimulation in Alzheimer's Disease Temporal Interference Stimulation - Alzheimer's Disease(AD) | Not applicable | Enrolling by invitation | First Affiliated Hospital of Zhejiang University | 30 | 2026-06-16 | 2026-07-27 |
| The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression Temporal Interference Stimulation - Major Depressive Disorder | Not applicable | Not yet recruiting | First Affiliated Hospital of Zhejiang University | 43 | 2026-06-01 | 2026-05-27 |
| The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease Temporal Interference Stimulation - Parkinson s Disease | Not applicable | Completed | The First Affiliated Hospital of Anhui Medical University | 96 | 2026-05-06 | 2026-08-11 |
| Research on the Efficacy and Safety of Targeted Suprachiasmatic Nucleus Electrical Stimulation for Improving Metabolic Disorders in Patients With Stable Bipolar Disorder Comorbid With Obesity Temporal Interference Stimulation, Sham Temporal Interference Stimulation Arm Description - Bipolar Disorder (BD) | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 70 | 2026-04-27 | 2026-05-27 |
| Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome Temporal Interference Stimulation - Parkinson Disease, Parkinson Disease, Secondary | Not applicable | Recruiting | Ke Dong, MD | 60 | 2026-04-21 | 2026-07-21 |
| tTIS Targeted of the Striatum as an Intervention for MUD Patients Temporal Interference Stimulation, Shame - Amphetamine Use Disorders | Not applicable | Completed | Shanghai Mental Health Center | 53 | 2026-03-26 | 2026-09-02 |
| Clinical Study on the Safety and Efficacy of Temporal Interference Stimulation in the Treatment of Post-Stroke Aphasia temporal interference stimulation, speech and language therapy - Post-stroke Aphasia | Not applicable | Recruiting | The First Affiliated Hospital of Anhui Medical University | 40 | 2025-12-01 | 2026-03-24 |
| Efficacy and Safety of Temporal Interference Stimulation on Cognitive Function in Patients With Early-Stage Alzheimer's Disease Temporal Interference Stimulation, Sham Stimulation - Alzheimer Disease | Not applicable | Enrolling by invitation | Ruijin Hospital | 40 | 2025-11-01 | 2026-04-24 |
| Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression Temporal Interference Stimulation, Sham Temporal Interference Stimulation - Bipolar Depression | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 160 | 2025-05-20 | 2026-05-27 |
| Temporal Interference and Depression Temporal Interference stimulation, Sham stimulation - Major Depressive Disorder | Not applicable | Recruiting | Unity Health Toronto | 30 | 2025-05-15 | 2025-04-24 |
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Alzheimer Disease (3) · Bipolar Disorder (3) · Cognitive Dysfunction (3) · Depressive Disorder, Major (3) · Parkinson Disease (3) · Schizophrenia (3) · Drug Resistant Epilepsy (1) · Epilepsy (1) · Frontotemporal Dementia (1) · Parkinson Disease, Secondary (1) · Schizophrenia, Treatment-Resistant (1)
First Affiliated Hospital of Zhejiang University (5) · Central South University (2) · Ke Dong, MD (2) · Ruijin Hospital (2) · Shanghai Mental Health Center (2) · The First Affiliated Hospital of Anhui Medical University (2) · Beijing Sanbo Brain Hospital (1) · Duke University (1) · Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University (1) · Shanghai University of Sport (1) · Tianjin Huanhu Hospital (1) · Unity Health Toronto (1) · Zhimin Wang (1)
China (19) · Canada (1) · United States (1)
Min Zhao, PhD (2) · Birgit Frauscher (1) · Venkat Bhat, MD MSc (1)
R56NS148323 (1)