21 completed, 14 not yet recruiting, 9 recruiting, 2 enrolling by invitation. 18 Phase 4, 12 Phase 3, 11 Phase 1, 5 Phase 2, 1 Early Phase 1.
Follow Suzetrigine: new trials by email Literature Review of Suzetrigine trials Research Report on Suzetrigine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Suzetrigine Added to Multimodal Analgesia for Women Undergoing Minimally Invasive Hysterectomy Suzetrigine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 123 | 2026-11-01 | 2026-09-23 |
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery multimodal analgesia regimen without suzetrigine, Suzetrigine - Opioid Consumption, Postoperative, Multimodal Analgesia | Phase 3 | Not yet recruiting | Brigham and Women's Hospital | 100 | 2026-10-01 | 2026-09-18 |
| Post-op Analgesia of Nail Unit Procedures Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen - Nail Diseases | Phase 4 | Not yet recruiting | University of Miami | 45 | 2026-10-01 | 2026-10-01 |
| Suzetrigine for Postoperative Pain After Total Ankle Replacement Suzetrigine - Ankle Osteoarthritis, Postoperative Pain | Phase 4 | Not yet recruiting | Soheil Ashkani Esfahani | 28 | 2026-10-01 | 2026-09-30 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery Suzetrigine, Opioid standard care pain medicine - Knee Arthroplasty, Total, Post Operative Pain, Acute | Phase 4 | Not yet recruiting | Endeavor Health | 100 | 2026-09-01 | 2026-09-02 |
| Suzetrigine Versus Usual-care Opioids for Postop Pain in Sports Suzetrigine, Multimodal Pain Regimen - Postoperative Pain Management | Phase 4 | Not yet recruiting | University of California, Los Angeles | 140 | 2026-09-01 | 2026-07-31 |
| Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU) Suzetrigine, Standard Care (in control arm) - Opioid Consumption, Postoperative | Phase 4 | Recruiting | University of California, San Diego | 100 | 2026-07-02 | 2026-07-06 |
| Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty Suzetrigine - Knee Arthritis, Knee Osteoarthritis | Phase 4 | Not yet recruiting | Emory University | 75 | 2026-07-01 | 2026-06-03 |
| Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen Suzetrigine, acetaminophen - Analgesic Efficacy | Phase 3 | Recruiting | Wake Forest University Health Sciences | 80 | 2026-06-22 | 2026-07-28 |
| Suzetrigine for Opioid-Free Recovery After Cesarean Delivery Suzetrigine, Placebo - Cesarean Delivery, Cesarean Section | Phase 4 | Not yet recruiting | University of Texas at Austin | 90 | 2026-06-01 | 2026-04-16 |
| Effects of Efavirenz on the Pharmacokinetics of Suzetrigine in Healthy Participants Suzetrigine, Efavirenz - Pain | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 18 | 2026-05-07 | 2026-08-18 |
| Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery Suzetrigine, Placebo - Bariatric Surgery, Cardiac Surgery With Sternotomy | Phase 3 | Recruiting | Icahn School of Medicine at Mount Sinai | 235 | 2026-05-01 | 2026-05-14 |
| Evaluation of Pain Treatment After Total Knee Arthroplasty Suzetrigine, Placebo - Pain | Phase 4 | Recruiting | Vertex Pharmaceuticals Incorporated | 60 | 2026-04-24 | 2026-08-18 |
| The Role of NaV1.8 in Human Pain Models Suzetrigine, Lidocaine (drug), Control Solution - Pain, Acute Pain | Early Phase 1 | Completed | Medical University of Vienna | 67 | 2026-04-21 | 2026-06-24 |
Showing 20 of 47. Sign in to see all of them.
Pain (18) · Pain, Postoperative (16) · Acute Pain (9) · Agnosia (3) · Pelvic Organ Prolapse (2) · Skin Neoplasms (2) · Breast Diseases (1) · Common Cold (1) · Nail Diseases (1) · Osteoarthritis, Knee (1) · Urinary Incontinence, Stress (1)
Vertex Pharmaceuticals Incorporated (22) · Hospital for Special Surgery, New York (2) · Icahn School of Medicine at Mount Sinai (2) · University of California, Los Angeles (2) · University of California, San Diego (2) · Aditi Talkad (1) · AdventHealth (1) · Baylor Research Institute (1) · Brigham and Women's Hospital (1) · Duke University (1) · Emory University (1) · Endeavor Health (1) · Latigo Biotherapeutics (1) · Mayo Clinic (1) · Medical University of Vienna (1)
United States (41) · Australia (1) · Austria (1)
A Lenore Ackeman, MD, PhD (1) · Ajay Premkumar, MD (1) · Alexandra Sideris, PhD (1) · Amanda White, MD (1) · Andrew Bishara, MD (1) · Ashraf Habib (1) · Brian M Ilfeld, MD, MS (1) · Brian Morrison, MD (1) · Chandler W Rundle, MD (1) · Deanna C. Menapace, MD (1) · Himani Bhatt, DO (1) · Lorie M. Harper, MD, MSCI (1) · Meghan Kirskey, MD (1) · Michael J.M. Fischer, Professor (1) · Michael Lazar, MD (1)
PMID 37530822, PMID 41384808, PMID 35580314, PMID 40165940, PMID 41689837, PMID 42156226, PMID 42249666, PMID 42570176