7 recruiting, 3 not yet recruiting, 1 active not recruiting, 1 completed. 12 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Recruiting 7, Not yet recruiting 3, Active not recruiting 1, Completed 1 |
Follow Suzetrigine: new trials by email Literature Review of Suzetrigine trials Research Report on Suzetrigine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Assessing Suzetrigine for Pain Reduction Following Ureteroscopic Surgery multimodal analgesia regimen without suzetrigine, Suzetrigine - Opioid Consumption, Postoperative, Multimodal Analgesia | Phase 3 | Not yet recruiting | Brigham and Women's Hospital | 100 | 2026-10-01 | 2026-09-18 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen Suzetrigine, acetaminophen - Analgesic Efficacy | Phase 3 | Recruiting | Wake Forest University Health Sciences | 80 | 2026-06-22 | 2026-07-28 |
| Suzetrigine-enhanced MultimOdal Opioid-sparing THerapy in Cardiac and Bariatric SURGery Suzetrigine, Placebo - Bariatric Surgery, Cardiac Surgery With Sternotomy | Phase 3 | Recruiting | Icahn School of Medicine at Mount Sinai | 235 | 2026-05-01 | 2026-05-14 |
| Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN Suzetrigine, Placebo - Total Knee Replacement Surgery, Post-operative Pain | Phase 3 | Recruiting | Icahn School of Medicine at Mount Sinai | 235 | 2026-04-01 | 2026-04-23 |
| Evaluating Suzetrigine for Pain Control Following TKA Suzetrigine, Placebo - Postoperative Pain Following Knee Arthroplasty | Phase 3 | Not yet recruiting | AdventHealth | 210 | 2026-03-01 | 2026-01-22 |
| Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy Suzetrigine, Placebo (matched to SUZ) - Diabetic Peripheral Neuropathic Pain | Phase 3 | Recruiting | Vertex Pharmaceuticals Incorporated | 734 | 2025-11-21 | 2026-07-20 |
| Suzetrigine in Total Hip Arthroplasty Suzetrigine, Placebo - Total Hip Arthroplasty (THA), Total Hip Arthroplasty \(THA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 210 | 2025-11-03 | 2026-07-30 |
| Evaluation of the Long-term Safety and Effectiveness of Suzetrigine (SUZ) in Participants With Painful Diabetic Peripheral Neuropathy (DPN) Suzetrigine - Diabetic Peripheral Neuropathic Pain | Phase 3 | Active not recruiting | Vertex Pharmaceuticals Incorporated | 455 | 2024-12-18 | 2026-10-19 |
| Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy Suzetrigine, Placebo (matched to SUZ), Pregabalin - Diabetic Peripheral Neuropathic Pain | Phase 3 | Recruiting | Vertex Pharmaceuticals Incorporated | 1100 | 2024-10-01 | 2026-10-15 |
| A Single-arm Study to Evaluate Safety and Effectiveness of VX-548 for Acute Pain Suzetrigine - Pain | Phase 3 | Completed | Vertex Pharmaceuticals Incorporated | 258 | 2023-01-09 | 2025-07-01 |
Pain (4) · Pain, Postoperative (4) · Agnosia (2)
Vertex Pharmaceuticals Incorporated (4) · Hospital for Special Surgery, New York (2) · Icahn School of Medicine at Mount Sinai (2) · AdventHealth (1) · Brigham and Women's Hospital (1) · University of California, San Francisco (1) · Wake Forest University Health Sciences (1)
United States (11)
Alexandra Sideris, PhD (1) · Andrew Bishara, MD (1) · Himani Bhatt, DO (1) · Meghan Kirskey, MD (1) · Michael Lazar, MD (1) · Ramakanth Yakkanti, MD (1) · Stephen B Tatter, MD (1)