4 completed, 4 unknown, 3 recruiting, 1 active not recruiting. 8 Not applicable, 2 Phase 1, 2 Phase 2, 1 Phase 3, 1 Phase 4.
Follow Spermidine: new trials by email Literature Review of Spermidine trials Research Report on Spermidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy Spermidine, Placebo - Autophagy, Healthy Aging | Not applicable | Recruiting | Nutraland USA, Inc. | 70 | 2026-01-09 | 2026-06-30 |
| Assessment of the Effects and Safety of Spermidine Supplementation on Blood Lipids and Body Weight in Overweight or Obese Individuals With Hyperlipidemia Spermidine, Placebo - Obesity & Overweight, Hyperlipidemia | Not applicable | Recruiting | Shanghai 10th People's Hospital | 50 | 2026-01-01 | 2026-06-23 |
| Iterative Design Trial to Assess Dietary Supplements and Other Aging-targeted Therapies Spermidine - Aging, Longevity | Not applicable | Enrolling by invitation | Atria Research and Global Health Institute (ARGHI) | 10 | 2025-09-01 | 2025-10-01 |
| A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation lamivudine, rapamycin, Exercise Regimen - Smokers, Former Smokers | Phase 1 | Active not recruiting | Icahn School of Medicine at Mount Sinai | 20 | 2025-08-12 | 2026-08-27 |
| A Randomized Controlled Trial of Spermidine for the Prevention of Radiation-Induced Xerostomia in Head and Neck Squamous Cell Carcinoma (Including Nasopharyngeal Carcinoma) Spermidine, Spermidine simulants - Radiation-induced Xerostomia | Phase 1 / Phase 2 | Recruiting | West China Hospital | 58 | 2025-06-25 | 2025-06-26 |
| This Study Evaluates the Clinical Effect of Adding Spermidine Gel to Minimally Invasive Non-surgical Periodontal Therapy (MINST) to Improve Periodontal Health. spermidine and minimally invasive non surgical tecnique, peridontal therapy (minimally invasive non surgical tecnique) - Peridontitis | Phase 4 | Completed | Luca Ramaglia | 13 | 2025-01-25 | 2026-07-15 |
| Polyamine Treatment in Elderly Patients With Coronary Artery Disease Spermidine, Placebo - Ischemic Heart Disease, Myocardial Infarction | Phase 2 | Completed | University of Aarhus | 187 | 2024-01-01 | 2026-07-01 |
| Bioavailability of Spermidine in Healthy Males spermidine - Healthy Subjects | Not applicable | Unknown | Chrysea Labs Lda | 6 | 2023-05-05 | 2024-08-30 |
| Metabolic Responses to Spermidine Supplementation. oral spermidine - Healthy Subjects | Not applicable | Unknown | Chrysea Labs Lda | 42 | 2022-08-14 | 2024-08-30 |
| Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine Spermidine or Placebo - COVID-19, Vaccine Reaction | Not applicable | Completed | University of Oxford | 40 | 2022-08-01 | 2024-05-09 |
| Absorption and Digestion Kinetics of Human Metabolites Spermidine, Nicotinamide, PEA - Postprandial Inflammation | Not applicable | Completed | University of California, Davis | 5 | 2021-04-08 | 2021-08-23 |
| An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation Spermidine (spermidineLIFE ®) OR Placebo - Depression, Healthy | Not applicable | Unknown | University Hospital, Bonn | 80 | 2020-12-01 | 2022-11-10 |
| Spermidine Anti-Hypertension Study Placebo, Spermidine - Hypertension | Phase 3 | Unknown | Medical University of Graz | 46 | 2020-02-25 | 2023-01-10 |
Hypertension (2) · Obesity (2) · COVID-19 (1) · Cardiovascular Diseases (1) · Cognition Disorders (1) · Cognitive Dysfunction (1) · Coronary Artery Disease (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Feeding Behavior (1) · Heart Diseases (1) · Hyperlipidemias (1) · Inflammation (1) · Insulin Resistance (1) · Metabolic Syndrome (1)
Chrysea Labs Lda (2) · Atria Research and Global Health Institute (ARGHI) (1) · Icahn School of Medicine at Mount Sinai (1) · Luca Ramaglia (1) · Medical University of Graz (1) · Nutraland USA, Inc. (1) · Shanghai 10th People's Hospital (1) · University Hospital, Bonn (1) · University of Aarhus (1) · University of California, Davis (1) · University of Oxford (1) · West China Hospital (1)
United States (5) · China (2) · Austria (1) · Denmark (1) · Germany (1) · Ireland (1) · Italy (1) · United Kingdom (1)
Dirk von Lewinski, MD (1) · Dr Patrick Keohane (1) · Henrik Wiggers, DMSC PHD MD (1) · Kathleen Kelley, MD (1) · Katja Simon, Prof. (1) · Mahmoud Abdellatif, MD, PhD (1) · Simon Sedej, PhD (1) · Thomas Marron, MD, PhD (1) · Tobias Eisenberg, PhD (1)
PMID 19801973, PMID 23332541, PMID 26254058, PMID 27841876, PMID 28529316, PMID 29371440, PMID 30388439, PMID 39405978, PMID 39549554, PMID 41168834, PMID 42000692, PMID 42460130