338 completed, 79 unknown, 66 terminated, 53 recruiting. 609 Phase 3, 132 Phase 2.
Follow Sodium Chloride: new trials by email Literature Review of Sodium Chloride trials Research Report on Sodium Chloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aspirin in Acute Pneumonia in the Elderly: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial. Acetylsalicylic acid/Aspirin (100 mg), Placebo acetylsalicylic acid (100 mg) / 0.9% sodium chloride - Acute Pneumonia, Elderly Person | Phase 3 | Not yet recruiting | Centre Hospitalier Universitaire Dijon | 600 | 2028-07-01 | 2026-09-24 |
| Echinocandin Added to Standard Treatment for Severe Pneumocystis Pneumonia Echinocandins, Placebo (0.9% Sodium chloride) infusion - Pneumocystis Jirovecii Pneumonia | Phase 3 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 416 | 2027-04-01 | 2026-10-28 |
| A Study to Evaluate the Maintenance of Efficacy and Long-term Safety of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1) CBL-514 Injection, 0.9 % sodium chloride - Subcutaneous Fat | Phase 3 | Not yet recruiting | Caliway Biopharmaceuticals Co., Ltd. | 300 | 2026-12-01 | 2026-10-19 |
| Investigation of Growth Hormone and Platelet-Rich Plasma on Joint Health Intra-Articular Injection of Growth Hormone and Platelet-Rich Plasma, Saline (NaCl 0,9 %) (placebo) - Arthritis Ankle, Arthritis Knee | Phase 2 / Phase 3 | Not yet recruiting | Integrant Pty Ltd | 192 | 2026-11-01 | 2026-08-26 |
| A Clinical Trial Evaluating the Efficacy and Safety of Local Infiltration of RF16001 for Injection for Analgesia After Total Hip Arthroplasty in China RF16001 for injection, Ropivacaine hydrochloride injection, 0.9% sodium chloride injection - Pain After Abdominal Surgery | Phase 3 | Enrolling by invitation | The Third Xiangya Hospital of Central South University | 300 | 2026-10-10 | 2026-10-14 |
| Intrauterine G-CSF Infusion for Thin Endometrium Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline - Thin Endometrium, Female Infertility | Phase 3 | Not yet recruiting | Nanjing University | 620 | 2026-10-01 | 2026-07-09 |
| MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation Magnesium Sulfate 2g, Magnesium Sulfate 4g, Saline (0.9% NaCl) - Atrial Flutter With Rapid Ventricular Response | Phase 3 | Not yet recruiting | Wake Forest University Health Sciences | 196 | 2026-10-01 | 2026-06-29 |
| Oral or Topical Catechins for Radiation Dermatitis Epicatechin, Epigallocatechin Gallate (EGCG), Microcrystalline Cellulose NF (placebo) - Radiation Dermatitis Acute, Radiation Dermatitis | Phase 3 | Enrolling by invitation | CARLOS FRANCISCO SAAVEDRA GARCIA | 162 | 2026-10-01 | 2026-09-11 |
| A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat ( SUPREME-02 ) CBL-514 Injection, 0.9% Sodium Chloride - Subcutaneous Fat | Phase 3 | Not yet recruiting | Caliway Biopharmaceuticals Co., Ltd. | 320 | 2026-10-01 | 2026-10-20 |
| THE ROLE OF PANCREATIC STONE PROTEIN (PSP) AND PSP-GUIDED EARLY MEROPENEM TREATMENT TO MITIGATE SEPSIS RISK AT THE EMERGENCY DEPARTMENT: THE PROMISE DOUBLE BLIND, PHASE III, RANDOMIZED CONTROLLED CLINICAL TRIAL Meropenem Infusion, Sodium Chloride (NaCl) 0.9 % - Sepsis | Phase 3 | Recruiting | Hellenic Institute for the Study of Sepsis | 398 | 2026-10-01 | 2026-11-03 |
| A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat CBL-514 Injection, 0.9% Sodium Chloride - Subcutaneous Fat | Phase 3 | Recruiting | Caliway Biopharmaceuticals Co., Ltd. | 320 | 2026-09-01 | 2026-10-19 |
| Outpatient Hypertonic Saline and Loop Diuretic Combination Therapy in Cardiorenal Hypertonic sodium chloride 10%, Sodium Chloride 0.9%, Furosemide intravenous solution - Heart Failure, Renal Disease, Chronic | Phase 3 | Not yet recruiting | University of Monastir | 60 | 2026-09-01 | 2026-07-15 |
| Early Corticosteroids in Severe Influenza Pneumonia Dexametasone, Sodium chloride 0.9% (placebo) - Severe Influenza, Intensive Care (ICU) | Phase 3 | Not yet recruiting | Centre Hospitalier Régional Metz-Thionville | 544 | 2026-09-01 | 2026-08-28 |
| Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy Sodium Chloride 0.9%, Dexamethasone, Chloroprocaine Injection [Clorotekal] - Knee Arthroscopy | Phase 3 | Not yet recruiting | CMC Ambroise Paré | 60 | 2026-09-01 | 2026-06-29 |
| Effect of Trilaciclib in the Prevention of Myelosupression in Subjects With Limited-stage Small Cell Lung Cancer Trilaciclib, Saline (0.9% NaCl) - Limited Stage Small Cell Lung Cancer | Phase 3 | Recruiting | Pharmacosmos A/S | 120 | 2026-09-01 | 2026-10-02 |
| Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section Lidocaine IV, Saline 0.9% - Intravenous Lidocaine, Fundal Pressure | Phase 3 | Recruiting | Tanta University | 680 | 2026-07-01 | 2026-07-06 |
| Subcutaneous Calcitonin in Acute Herpes Zoster Calcitonin, Saline - Calcitonin, Subcutaneous | Phase 3 | Recruiting | Tanta University | 168 | 2026-07-01 | 2026-07-06 |
| Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment Aprotinin (inhaled), Placebo (Sodium Chloride) - Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Recruiting | Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion | 156 | 2026-06-18 | 2026-07-15 |
| Investigating the Efficacy of Tranexamic Acid as a Prophylactic Agent in Reducing Postpartum Hemorrhage Among Patients Undergoing Cesarean Section in SQUH tranexamic acid (1 g diluted in 100 mL of 0.9% saline, Normal (0.9%) saline - Post Partum Haemorrhage | Phase 3 | Not yet recruiting | Sultan Qaboos University | 88 | 2026-05-01 | 2026-04-01 |
| Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial Dexamethasone 4 Mg/mL Injectable Solution, Dexamethasone 8Mg Solution for Injection, Saline (NaCl 0,9 %) (placebo) - Postoperative Pain | Phase 3 | Recruiting | Oman Ministry of Health | 138 | 2026-03-25 | 2026-03-30 |
Showing 20 of 609. Sign in to see all of them.
Pain, Postoperative (33) · COVID-19 (26) · Pain (26) · Osteoarthritis (20) · Agnosia (17) · Osteoarthritis, Knee (16) · Sepsis (13) · Acute Kidney Injury (12) · Hemorrhage (11) · Breast Neoplasms (10) · Postpartum Hemorrhage (9) · Postoperative Nausea and Vomiting (8) · Wounds and Injuries (8) · Angioedemas, Hereditary (7) · Atrial Fibrillation (7)
Assiut University (14) · Pfizer (9) · Copenhagen University Hospital, Rigshospitalet (8) · Assistance Publique - Hôpitaux de Paris (7) · Cairo University (6) · London School of Hygiene and Tropical Medicine (5) · Qingyuan Zhan (5) · Tanta University (5) · University Health Network, Toronto (5) · Ain Shams University (4) · Ampio Pharmaceuticals. Inc. (4) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (4) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4) · Meir Medical Center (4) · Merck Sharp & Dohme LLC (4)
United States (180) · Canada (65) · France (59) · Germany (47) · Egypt (40) · Denmark (38) · Spain (38) · Australia (34) · United Kingdom (34) · Italy (33) · China (32) · Belgium (28) · Brazil (26) · Poland (24) · Netherlands (23)
Viktoria Lindberg-Larsen, MD (6) · Anne Sheu (3) · Omer Mei Dan, Dr (3) · Pablo M Ingelmo, MD (3) · Stuart D Miller, MD (3) · Yi Ba, MD.PHD (3) · Adrian Vella, MD (2) · Anne Marie Rosendahl Madsen, MD (2) · Avroy A. Fanaroff, MD (2) · Barbara J. Stoll, MD (2)
PMID 20554319, PMID 39162220, PMID 42159953, PMID 17180268, PMID 18633034, PMID 20487038, PMID 20818886, PMID 20920772, PMID 21883197, PMID 22900785, PMID 23312695, PMID 25080874, PMID 25500317, PMID 26452709, PMID 28284978, PMID 29156068, PMID 31112399, PMID 32492040, PMID 33026630, PMID 33026631, PMID 38470985, PMID 39186385, PMID 39301879, PMID 10582782, PMID 10625862, PMID 10691234, PMID 10910490, PMID 10910857, PMID 11020770, PMID 11150359, PMID 12010907, PMID 12114906, PMID 12219057, PMID 12563043, PMID 12826855, PMID 15023840, PMID 15121942, PMID 15150204, PMID 15316237, PMID 15317861, PMID 15510034, PMID 15983467, PMID 16352625, PMID 16508405, PMID 16698416, PMID 17405780, PMID 1777459, PMID 17882910, PMID 18347861, PMID 18702902
2019 (10), 2023 (7), 2015 (6), 2016 (6), 2014 (4), 2017 (4), 2008 (3), 2009 (3), 2018 (3), R01DK126206 (3), 2025 (2), M01RR000070 (2), M01RR000750 (2), M01RR000997 (2), M01RR006022 (2)