142 completed, 25 unknown, 20 terminated, 13 withdrawn. 61 Phase 2, 58 Phase 4, 44 Phase 3, 37 Phase 1, 21 Not applicable.
Follow Sildenafil: new trials by email Literature Review of Sildenafil trials Research Report on Sildenafil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment Sildenafil - Cancer | Phase 2 / Phase 3 | Not yet recruiting | The University of Texas Medical Branch, Galveston | 30 | 2027-06-15 | 2026-05-11 |
| Asciminib With or Without Sildenafil for Brain Tumors Asciminib, Sildenafil, Surgical resection or biopsy - Brain Tumor | Early Phase 1 | Not yet recruiting | Washington University School of Medicine | 12 | 2026-10-31 | 2026-09-11 |
| Randomized Study of Triple Therapy vs Sildenafil Dose Optimization in Pulmonary Arterial Hypertension Prostacyclin Pathway Agent, Sildenafil Dose Optimization - Pulmonary Arterial Hypertension (PAH) | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 196 | 2026-07-22 | 2026-07-30 |
| Phase 2 Efficacy Study of Sildenafil Products in Adult Men With Erectile Dysfunction Hezkue, Hezkue Turbo, Galotam - Erectile Dysfunction | Phase 2 | Not yet recruiting | Aspargo Labs, Inc | 200 | 2026-01-01 | 2025-11-19 |
| Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal Cancer Sildenafil, Placebo - Rectal Cancer | Phase 3 | Recruiting | University Hospital, Rouen | 188 | 2025-09-25 | 2026-05-12 |
| Intrapartum Sildenafil in Laboring Mothers Sildenafil 50 mg Oral Tablet, Placebo Oral Tablet - Neonatal Asphyxia, Intrapartum Fetal Distress | Phase 3 | Withdrawn | University of Alabama at Birmingham | 2025-05-01 | 2025-09-16 | |
| Sildenafil to Reduce Vascular Remodeling During Left Ventricular Assist Device Support Sildenafil, Placebo - Vascular Diseases | Early Phase 1 | Recruiting | Montefiore Medical Center | 50 | 2025-03-12 | 2026-01-23 |
| Safety and Tolerability of TOP-N53 Applied on Digital Ulcers in Patients With Systemic Sclerosis TOP-N53, Sildenafil, TOP-N53 vehicle - Digital Ulcers in Systemic Sclerosis | Phase 2 | Recruiting | Topadur Pharma AG | 15 | 2025-02-04 | 2026-10-01 |
| The Effect of Combination of Dapagliflozin and Sildenafil in Treatment of Heart Failure Patients With Secondary Pulmonary Hypertension Dapagliflozin (DAPA), Sildenafil - Heart Failure NYHA Class II | Not applicable | Completed | Fayoum University | 100 | 2025-01-20 | 2025-09-03 |
| Delayed Dose Collagenase Clostridium Histolyticum (CCH) Protocol for Men With Peyronie's Disease Collagenase Clostridium Histolyticum, RestoreX, Sildenafil - Peyronie Disease | Phase 4 | Active not recruiting | Charitable Union for the Research and Education of Peyronie's Disease | 40 | 2024-10-11 | 2026-08-26 |
| Treatment of Neonatal Encephalopathy With Oral Sildenafil Suspension to Repair Brain Injury Secondary to Birth Asphyxia Sildenafil, Ora-Blend - Neonatal Encephalopathy | Phase 2 | Recruiting | Pia Wintermark | 60 | 2024-07-01 | 2026-09-17 |
| PEnile ReHABilitation After Nerve Sparing Robot-assisted Radical Prostatectomy for Prostate Cancer 2.0 (PEHAB-II) Sildenafil, Erectile vacuum device - Erectile Dysfunction Following Radical Prostatectomy | Phase 4 | Recruiting | The Netherlands Cancer Institute | 198 | 2024-01-15 | 2025-03-13 |
| Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children Sildenafil, Milrinone - Persistent Pulmonary Hypertension of the Newborn | Not applicable | Completed | Muhammad Aamir Latif | 42 | 2023-12-01 | 2024-08-26 |
| Effect of Tadalafil, Sildenafil and Pentoxyfylline on Frozen Embryo Transfer Outcomes tadalafil, Sildenafil, pentoxifylline - IVF | Phase 2 / Phase 3 | Unknown | Beni-Suef University | 200 | 2023-07-30 | 2023-08-03 |
| Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease Sildenafil, Placebos - Single-ventricle, Pulmonary Hypertension | Phase 3 | Withdrawn | University Hospital, Montpellier | 2023-06-01 | 2023-05-15 | |
| Using Thermography to Assess the Affects of Sildenafil Cream, 3.6% Sildenafil, Vehicle, Placebo - Sexual Arousal Disorder | Phase 1 | Completed | Daré Bioscience, Inc. | 13 | 2023-05-13 | 2025-09-04 |
| Vardenafil Vs Sildenafil for the Treatment of Pulmonary Hypertension of the Newborn Vardenafil, Sildenafil - PPHN | Phase 1 / Phase 2 | Completed | Damascus University | 55 | 2023-05-01 | 2025-03-06 |
| Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab Sildenafil, Placebo - Migraine Without Aura | Not applicable | Completed | Danish Headache Center | 16 | 2023-04-20 | 2023-10-24 |
| A Study Investigating the Safety, Tolerability, Drug Levels and Drug Effect of BMS-986278 in Healthy Adult Participants (Part 1) and Japanese Participants (Part 2) BMS-986278, Sildenafil, Placebo - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 61 | 2023-01-03 | 2023-08-24 |
| Hypersensitivity to Phosphodiesterase 5 Inhibition in Post-Traumatic Headache Sildenafil, Placebo - Post-Traumatic Headache | Not applicable | Unknown | Danish Headache Center | 21 | 2023-01-02 | 2023-02-08 |
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Hypertension, Pulmonary (35) · Erectile Dysfunction (29) · Pulmonary Arterial Hypertension (16) · Heart Failure (11) · Hypertension (6) · Idiopathic Pulmonary Fibrosis (6) · Fatigue (5) · Pulmonary Disease, Chronic Obstructive (5) · Asphyxia Neonatorum (4) · Cystic Fibrosis (4) · Fetal Growth Retardation (4) · Heart Failure, Diastolic (4) · Motor Activity (4) · Anemia, Sickle Cell (3) · Diabetes Mellitus, Type 2 (3)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (23) · The University of Texas Medical Branch, Galveston (6) · Eli Lilly and Company (5) · Bayer (4) · Pfizer (4) · University of Milan (4) · Actelion (3) · Danish Headache Center (3) · Johns Hopkins University (3) · Mansoura University (3) · Massachusetts General Hospital (3) · National Jewish Health (3) · University of British Columbia (3) · Ain Shams University (2) · Assiut University (2)
United States (83) · Canada (20) · United Kingdom (16) · Italy (15) · Denmark (13) · France (13) · Germany (13) · Egypt (12) · Spain (11) · Belgium (8) · Brazil (7) · Israel (7) · South Korea (7) · Japan (6) · Netherlands (6)
Melinda Sheffield-Moore, PhD (4) · Jennifer L Taylor-Cousar, MD (3) · Andrew S. Poklepovic, MD (2) · Marc J Semigran, MD (2) · Omar Saeed, MD (2) · A. van Wassenaer, MD PhD (1) · Abdur Rehman, FCPS (1) · Ahmed M. Asmy, MD (1) · Ahmed R EL-Nahas, MD (1) · Aiden Abidov, MD, PhD (1)
PMID 29282009, PMID 10851208, PMID 10922975, PMID 10987609, PMID 11259809, PMID 11557915, PMID 11596671, PMID 11927799, PMID 12119802, PMID 12145231, PMID 12923400, PMID 15738343, PMID 16391172, PMID 16533484, PMID 18426998, PMID 18647982, PMID 18716761, PMID 19047577, PMID 19738158, PMID 19875684, PMID 19919979, PMID 20012639, PMID 20368443, PMID 20739168, PMID 21036891, PMID 21219411, PMID 21292991, PMID 21382896, PMID 21527519, PMID 21709061, PMID 21875912, PMID 21900080, PMID 22354598, PMID 22447809, PMID 22496161, PMID 22801444, PMID 22983573, PMID 22991405, PMID 23097067, PMID 23266540, PMID 23406672, PMID 23429918, PMID 23478662, PMID 23585527, PMID 24162898, PMID 24447534, PMID 24656411, PMID 24833648, PMID 24988120, PMID 25042693
2008 (2), 2015 (2), 2017 (2), U01HL065238 (2), 1UL1TR002373-01 (1), 2009 (1), 2016 (1), 2019 (1), K23HL103976 (1), K23HL145140 (1), R01HL130883 (1), R01HL172972 (1), R61HL147833 (1), U01HL065232 (1), U01HL065233 (1)