60 completed, 33 recruiting, 13 not yet recruiting, 11 active not recruiting. 93 Not applicable, 22 Phase 2, 18 Phase 3, 4 Phase 1, 4 Phase 4.
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| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vagus Nerve Stimulation on Improving Sleep in Inpatient Rehab for Post-Acute Stroke transauricular Vagal Nerve Stimulation, Sham Comparator - Stroke, Ischemic Cerebrovascular Accident | Not applicable | Not yet recruiting | Casa Colina Hospital and Centers for Healthcare | 52 | 2026-10-16 | 2026-10-08 |
| Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait Subperceptual Stimulus, Sham Comparator - Vestibular Disorder, Aging | Not applicable | Recruiting | Massachusetts Eye and Ear Infirmary | 120 | 2026-09-25 | 2026-06-23 |
| Transcranial Direct Current Stimulation for the Treatment of Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors Sham Intervention, Survey Administration, Transcranial Direct Current Stimulation - Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphatic System Neoplasm | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 50 | 2026-09-10 | 2026-10-15 |
| Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder Closed-loop tACS, Sham Comparator - Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation | Not applicable | Recruiting | Pulvinar Neuro, LLC | 214 | 2026-09-01 | 2026-10-08 |
| Transcranial Direct Current Stimulation to Improve Gait for Breast Cancer Survivor's Who Received Taxene and/or Platinum Chemotherapy Sham Intervention, Survey Administration, Transcranial Direct Current Stimulation - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Not yet recruiting | University of Michigan Rogel Cancer Center | 60 | 2026-09-01 | 2026-10-08 |
| New York Better Breathing Study Biospecimen Collection, Electronic Health Record Review, Medical Device Usage and Evaluation - Localized Lung Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Roswell Park Cancer Institute | 100 | 2026-04-20 | 2026-05-28 |
| Assess Efficacy of a Nanodiamond Periprocedural Skin Care Regimen for Ablative Resurfacing Pavise Serum, Sham Comparator, Co2/Er:YAG - Skin Laxity | Phase 2 | Not yet recruiting | Goldman, Butterwick, Fitzpatrick and Groff | 8 | 2026-03-20 | 2026-03-10 |
| Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Management During Labor. Transcutaneous Electrical Nerve Stimulation (TENS); TENSCARE Perfect Mama+ TENS unit, Sham Comparator - Labor Pain | Not applicable | Recruiting | Ricardo A Gutierrez Ramirez, MD, MSc, FACOG | 132 | 2026-02-15 | 2026-02-13 |
| Electrotherapy Stimulation Together With Life Coaching for the Support of Burnout Symptoms in Healthcare Workers Cranial Electrical Stimulation (CES), Discussion, Health and Wellness Coach - Psychiatric Disorder | Not applicable | Recruiting | Roswell Park Cancer Institute | 40 | 2026-02-04 | 2026-09-09 |
| Immunoadsorption in Autoimmune Long COVID Immunoadsorption, Sham Comparator - Long COVID, Long COVID Syndrome | Phase 2 | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 70 | 2026-01-01 | 2026-01-05 |
| Protective Effect of EECP Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery Enhanced External Counterpulsation (EECP), Sham Comparator - Coronary Heart Disease (CHD), Cardio-pulmonary Bypass | Not applicable | Not yet recruiting | Nanjing Medical University | 400 | 2025-12-31 | 2024-12-11 |
| Investigating the Feasibility of Combining Virtual Reality and Bilateral Transcranial Direct Stimulation to Improve Upper Limb Recovery in Patients With Stroke Transcranial Direct Current Stimulation combined with virtual reality, Sham Comparator - Brain Diseases, Central Nervous System Diseases | Not applicable | Recruiting | King Saud University | 100 | 2025-12-28 | 2025-12-30 |
| Effects of Transcutaneous Vagus Nerve Stimulation in Older Adults Active location tVNS, Sham Comparator - Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance | Not applicable | Completed | Universidade da Coruña | 12 | 2025-12-19 | 2026-03-02 |
| Non-invasive Ultrasound and Hematoma Clearance After Intracerebral Hemorrhage non-invasive ultrasonic scalpel, Sham Comparator - Intracerebral Hemorrhage | Not applicable | Recruiting | Beijing Tiantan Hospital | 86 | 2025-12-12 | 2026-04-17 |
| Effects of tDCS on Motor Cortex During ACL Recovery NIBS, Rehabilitation, Sham Comparator - Anterior Cruciate Ligament Reconstruction Rehabilitation | Not applicable | Recruiting | Fundación Universidad Católica de Valencia San Vicente Mártir | 54 | 2025-11-28 | 2025-12-02 |
| A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration SAR446597, Sham Comparator - Geographic Atrophy | Phase 1 / Phase 2 | Recruiting | Sanofi | 104 | 2025-10-09 | 2026-10-20 |
| Sleep and Performance Transcranial Electric Stimulation, Sham Comparator - Sleep, Glymphatic System | Not applicable | Recruiting | University of Washington | 16 | 2025-10-01 | 2026-05-27 |
| Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery Experimental Treatment, Sham Comparator - Rotator Cuff Tears, Shoulder Injuries | Not applicable | Completed | University of California, San Diego | 44 | 2025-09-05 | 2026-07-27 |
| Implementation of a Diabetic Foot Prevention Strategy in Primary Care (iMplanta Study) Implementation strategy developed using the Implementation Mapping model to enhance the effective integration of the Protocol for Assistance to People with Diabetic Foot, Sham Comparator - Diabetic Foot Disease, Diabetic Foot Ulcer (DFU) | Not applicable | Not yet recruiting | University of the Balearic Islands | 1520 | 2025-09-01 | 2025-06-29 |
| Acupuncture for Lung Cancer-Related Fatigue Acupuncture, Sham Comparator - Lung Cancer | Not applicable | Not yet recruiting | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | 120 | 2025-08-01 | 2025-07-25 |
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Stroke (5) · Depression (4) · Depressive Disorder, Major (4) · Geographic Atrophy (4) · Schizophrenia (4) · Sleep Initiation and Maintenance Disorders (4) · Acute Pain (3) · Agnosia (3) · Heart Failure (3) · Inflammation (3) · Lung Neoplasms (3) · Macular Edema (3) · Motor Activity (3) · Osteoarthritis, Knee (3) · Pain, Postoperative (3)
University of California, San Diego (5) · Assistance Publique - Hôpitaux de Paris (4) · Hopital Foch (3) · Universidade Federal de Pernambuco (3) · CytoSorbents, Inc (2) · Emory University (2) · EyePoint Pharmaceuticals, Inc. (2) · Goldman, Butterwick, Fitzpatrick and Groff (2) · Guang'anmen Hospital of China Academy of Chinese Medical Sciences (2) · Kodiak Sciences Inc (2) · Mayo Clinic (2) · Prokidney (2) · Pulvinar Neuro, LLC (2) · Roswell Park Cancer Institute (2) · SuperPatch Limited LLC (2)
United States (77) · France (9) · Spain (9) · Canada (8) · China (6) · Turkey (Türkiye) (6) · United Kingdom (6) · Australia (5) · Brazil (4) · Germany (4) · Netherlands (4) · Puerto Rico (4) · India (3) · New Zealand (3) · Russia (3)
Brendan L McNeish (2) · Brian M Ilfeld, MD, MS (2) · C. M Gibson, MD (2) · Michael J Mack, MD (2) · Mireille Michel-Cherqui, MD (2) · Adrienne Randolph, MD (1) · Ahmet Ali Tuncer, Asst Prof Dr (1) · Alexander Kharlamov, M.D., Ph.D. (1) · Alexandre F DaSilva, DDS, DMedSc (1) · Amy Gallagher, PsyD (1) · Andreana Benitez, PhD (1) · Andrew D Ray (1)
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2014 (1), 2018 (1), 2023 (1), 2025 (1), K23AG090624 (1), M01RR000039 (1), M01RR000750 (1), M01RR000997 (1), M01RR001032 (1), M01RR002172 (1), M01RR002635 (1), M01RR006022 (1), M01RR008084 (1), R01AG073161 (1), R01AG081237 (1)