25 completed, 4 terminated, 2 unknown. 18 Phase 2, 15 Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 15, Terminated 3 |
| Phase 1 | 15 | Completed 13, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Completed 1 |
Follow Semaxinib: new trials by email Literature Review of Semaxinib trials Research Report on Semaxinib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SU5416 Plus Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer bicalutamide, flutamide, goserelin acetate - Prostate Cancer | Phase 1 | Completed | University of Chicago | 3 | 2001-11-01 | 2013-09-05 |
| Radiation Therapy With or Without SU5416 in Treating Patients With Soft Tissue Sarcoma semaxanib, conventional surgery, radiation therapy - Sarcoma | Phase 1 / Phase 2 | Completed | Radiation Therapy Oncology Group | 2001-08-01 | 2013-06-24 | |
| Chemotherapy, SU5416, Radiation Therapy, and Surgery in Treating Patients With Soft Tissue Sarcoma filgrastim, dacarbazine, doxorubicin hydrochloride - Sarcoma | Phase 1 / Phase 2 | Completed | Radiation Therapy Oncology Group | 2001-08-01 | 2013-06-24 | |
| Thalidomide and SU5416 in Treating Patients With Metastatic Melanoma semaxanib, thalidomide - Melanoma (Skin) | Phase 2 | Completed | National Cancer Institute (NCI) | 35 | 2001-03-01 | 2013-02-11 |
| SU5416 in Treating Patients With Metastatic Kidney Cancer That Has Not Responded to Previous Treatment semaxanib - Recurrent Renal Cell Cancer, Stage IV Renal Cell Cancer | Phase 2 | Terminated | National Cancer Institute (NCI) | 50 | 2000-12-01 | 2013-01-23 |
| Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer FOLFIRI regimen, fluorouracil, irinotecan hydrochloride - Colorectal Cancer | Phase 3 | Unknown | Jonsson Comprehensive Cancer Center | 2000-12-01 | 2013-12-19 | |
| SU5416 in Treating Patients With Advanced or Recurrent Cancer of the Head and Neck semaxanib - Carcinoma of Unknown Primary, Head and Neck Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 2000-12-01 | 2009-12-04 | |
| SU5416 and Interferon Alfa-2b in Treating Patients With Unresectable or Metastatic Kidney Cancer recombinant interferon alfa, semaxanib - Kidney Cancer | Phase 2 | Completed | City of Hope Medical Center | 2000-11-01 | 2011-10-20 | |
| SU5416 and Paclitaxel in Treating Patients With Advanced Cancer paclitaxel, semaxanib - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | City of Hope Medical Center | 2000-11-01 | 2010-01-13 | |
| SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomas semaxanib - Gastrointestinal Stromal Tumor, Sarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2000-10-01 | 2013-02-11 |
| SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer semaxanib - Colorectal Cancer | Phase 2 | Terminated | National Cancer Institute (NCI) | 37 | 2000-08-01 | 2013-06-03 |
| SU5416 in Treating Patients With Malignant Mesothelioma semaxanib - Malignant Mesothelioma | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2000-08-01 | 2013-06-03 |
| SU5416 and Carboplatin to Treat Ovarian Cancer SU5416 and carboplatin - Fallopian Tube Neoplasm, Ovarian Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 33 | 2000-08-01 | 2008-03-04 |
| SU5416 in Treating Children With Recurrent or Progressive Brain Tumors semaxanib - Brain and Central Nervous System Tumors | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 33 | 2000-08-01 | 2009-10-14 |
| SU5416, Irinotecan, and Cisplatin in Treating Patients With Advanced Solid Tumors cisplatin, irinotecan hydrochloride, semaxanib - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 2000-08-01 | 2013-01-31 | |
| SU5416 in Treating Patients With Metastatic Melanoma That Has Been Previously Treated semaxanib, laboratory biomarker analysis - Recurrent Melanoma, Stage IV Melanoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 35 | 2000-07-01 | 2013-01-24 |
| SU5416 Compared to Dexamethasone in Treating Patients With Progressive Prostate Cancer That Has Not Responded to Hormone Therapy dexamethasone, semaxanib - Prostate Cancer | Phase 2 | Completed | University of Chicago | 36 | 2000-06-01 | 2013-09-05 |
| SU5416 in Treating Patients With Refractory or Relapsed Multiple Myeloma semaxanib - Multiple Myeloma and Plasma Cell Neoplasm | Phase 2 | Completed | Fox Chase Cancer Center | 21 | 2000-06-01 | 2013-07-11 |
| SU5416 in Treating Patients With Advanced Solid Tumors semaxanib - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | Case Comprehensive Cancer Center | 19 | 2000-05-01 | 2010-06-11 |
| SU5416 and Paclitaxel in Treating Patients With Recurrent, Locally Advanced or Metastatic Cancer of the Head and Neck paclitaxel, semaxanib - Head and Neck Cancer | Phase 1 | Completed | Case Comprehensive Cancer Center | 12 | 2000-05-01 | 2010-06-10 |
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Sarcoma (5) · Colonic Neoplasms (4) · Rectal Neoplasms (4) · Sarcoma, Kaposi (4) · Colorectal Neoplasms (3) · Skin Neoplasms (3) · AIDS-related Kaposi sarcoma (2) · Astrocytoma (2) · Carcinoma, Renal Cell (2) · Central Nervous System Neoplasms (2) · HIV Infections (2) · Head and Neck Neoplasms (2) · Melanoma (2) · Oligodendroglioma (2) · Prostatic Neoplasms (2)
National Cancer Institute (NCI) (9) · Case Comprehensive Cancer Center (3) · City of Hope Medical Center (2) · Jonsson Comprehensive Cancer Center (2) · Pfizer (2) · Radiation Therapy Oncology Group (2) · SUGEN (2) · University of Chicago (2) · AIDS Malignancy Consortium (1) · Fox Chase Cancer Center (1) · Gynecologic Oncology Group (1) · Memorial Sloan Kettering Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Pediatric Brain Tumor Consortium (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1)
United States (29) · Canada (2)
Alison L. Hannah, MBBS (2) · Burton L. Eisenberg, MD (2) · Hedy L. Kindler, MD (2) · Lee S. Rosen, MD (2) · Walter M. Stadler, MD, FACP (2) · Afshin Dowlati, MD (1) · Arlene Siefker-Radtke (1) · Beth A. Overmoyer, MD, FACP (1) · David G. Pfister, MD (1) · Eric H. Kraut, MD (1) · Eric K. Rowinsky, MD (1) · Francis Giles (1) · George D. Demetri, MD (1) · Howard A. Fine, MD (1) · James Abbruzzese (1)
PMID 12231519, PMID 14581348, PMID 19065567
P30CA043703 (3), U01CA062502 (3), N01CM17003 (2), P30CA033572 (2), U01CA062505 (2), N01CM17102 (1)