12 completed, 5 unknown, 2 active not recruiting, 1 not yet recruiting. 11 Not applicable, 4 Phase 2, 3 Phase 1, 2 Phase 4, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis Melatonin-Loaded Injectable Platelet-Rich Fibrin, injectible platelet rich fibrin (i-PRF ), scaling and root planning - Periodontitis Stage II | Phase 4 | Completed | Al-Azhar University | 30 | 2025-11-01 | 2026-11-09 |
| Non-surgical Periodontal Therapy and Kidney Outcomes in Type 2 Diabetes Mellitus scaling and root planning - Type 2 Diabetes Mellitus MeSH:D003924, Periodontitis MeSH:D010518 | Not applicable | Completed | Dow University of Health Sciences | 46 | 2025-05-15 | 2026-08-24 |
| Clinical and Immunological Evaluation of HA in Treatment of Periodontitis Hyaluronic acid, scaling and root planning - Periodontitis | Not applicable | Not yet recruiting | Sana'a University | 24 | 2025-04-01 | 2024-12-05 |
| The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis NSP and chitosan nanoparticles gel loaded by quercetin, NSP and chitosan nanoparticles gel, scaling and root planning - Periodontal Pocket | Phase 2 | Active not recruiting | Mansoura University | 60 | 2024-08-15 | 2025-05-21 |
| Efficacy of Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis curcurmin loaded on chitosan nano-particles, hyaluronic acid loaded on chitosan nano-particles, scaling and root planning - Periodontitis | Not applicable | Active not recruiting | Mansoura University | 40 | 2024-06-02 | 2025-05-20 |
| Effect Of Scaling and Root Planning on ALP in Saliva and GCF In Periodontitis Patients Compared With Healthy Individuals Scaling and Root Planning - Periodontitis, Healthy | Not applicable | Unknown | Cairo University | 134 | 2023-06-15 | 2023-09-21 |
| Periodontitis and Inflammation Periodontal or peri-implantitis treatment, Control treatment - Periodontitis, Peri-Implantitis | Recruiting | Assistance Publique - Hôpitaux de Paris | 219 | 2023-02-15 | 2026-01-21 | |
| Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects Melatonin gel, Metformin and melatonin gel, placebo gel - Bone Loss in Jaw | Phase 2 | Unknown | Amira ragab | 52 | 2022-12-14 | 2023-06-18 |
| Evaluation of Metronidazole Hydrogel 25% in Stage II and III Periodontitis metronidazole hydrogel, scaling and root planning - Periodontitis | Phase 4 | Completed | University of L'Aquila | 40 | 2021-07-07 | 2023-12-12 |
| Effect Of A Locally Delivered Probiotic Sacchraomyces Boulardii In The Management Of Chronic Periodontitis Saccharomyces Boulardii 250 MG - Chronic Periodontitis | Phase 1 / Phase 2 | Completed | Tatyasaheb Kore Dental College | 31 | 2017-11-20 | 2018-05-11 |
| Nonsurgical Periodontal Treatment in Patients With Social Phobia Non surgical periodontal treatment - Social Phobia, Periodontal Diseases | Not applicable | Unknown | University of Sao Paulo General Hospital | 45 | 2017-10-05 | 2017-08-07 |
| Does Hyaluronic Acid Affect Periodontal Treatment? Scaling and root planning, Hyaluronic acid gel (HA) and SRP, HA mouthrinse and SRP - Periodontitis | Phase 1 | Completed | Yuzuncu Yil University | 24 | 2017-08-30 | 2018-11-27 |
| Effect of Periodontal Debridement on Leptin Levels in Obese Scaling and root planning - Periodontitis, Obesity | Not applicable | Completed | Universidad Nacional Andres Bello | 27 | 2016-12-01 | 2020-07-13 |
| To Compare Efficacy of Low Dose Diclofenac (25mg) in Management of Postoperative Pain After Periodontal Flap Surgery low dose diclofenac - Chronic Periodontitis | Phase 1 / Phase 2 | Completed | Tatyasaheb Kore Dental College | 20 | 2016-03-20 | 2018-05-14 |
| Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers Scaling and root planing plus placebo, Photodynamic therapy (PDT) - Periodontal Disease | Early Phase 1 | Completed | University of Pristina | 120 | 2015-01-05 | 2026-07-13 |
| Metabolic Syndrome and Periodontitis Non surgical periodontal treatment - Metabolic Syndrome, Periodontal Disease | Not applicable | Unknown | Federal University of Rio Grande do Sul | 158 | 2014-05-01 | 2017-05-31 |
| Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients Antimicrobial photodynamic therapy, Scaling and root planning, red laser - Periodontal Diseases | Not applicable | Completed | University of Sao Paulo | 33 | 2013-10-01 | 2016-10-19 |
| Effects of Periodontal Therapy in Patients With Metabolic Syndrome Scaling and root planning, Supragingival Prophylaxis - Periodontitis, Metabolic Syndrome | Not applicable | Completed | Universidad Complutense de Madrid | 60 | 2012-11-28 | 2019-05-28 |
| The Impact of Obesity on Nonsurgical Periodontal Therapy Metronidazole, Placebo, Scaling and root planning - Periodontitis, Periodontal Diseases | Not applicable | Unknown | Federal University of Rio Grande do Sul | 96 | 2009-08-01 | 2011-07-29 |
| Diagnostic Biomarkers Related to Periodontal Disease Activity in Diabetic non-surgical periodontal therapy + systemic doxycycline, Non-surgical periodontal therapy - Periodontitis, Type 2 Diabetes Mellitus | Phase 3 | Completed | University of Sao Paulo | 56 | 2009-03-01 | 2014-08-20 |
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Periodontitis (12) · Periodontal Diseases (7) · Chronic Periodontitis (2) · Diabetes Mellitus, Type 2 (2) · Metabolic Syndrome (2) · Obesity (2) · Periodontal Attachment Loss (2) · Anxiety Disorders (1) · Diabetes Mellitus (1) · Diabetic Nephropathies (1) · Disease (1) · Down Syndrome (1) · Inflammation (1) · Peri-Implantitis (1) · Periodontal Pocket (1)
University of Sao Paulo (3) · Federal University of Rio Grande do Sul (2) · Mansoura University (2) · Tatyasaheb Kore Dental College (2) · Al-Azhar University (1) · Amira ragab (1) · Assistance Publique - Hôpitaux de Paris (1) · Cairo University (1) · Dow University of Health Sciences (1) · Sana'a University (1) · Universidad Complutense de Madrid (1) · Universidad Nacional Andres Bello (1) · University of L'Aquila (1) · University of Pristina (1) · University of Sao Paulo General Hospital (1)
Brazil (6) · Egypt (5) · India (2) · Chile (1) · France (1) · Italy (1) · Pakistan (1) · Turkey (Türkiye) (1) · Yemen (1)
Dilip Khambete, MDS (2) · Adriana P Sant'Ana, DDS PhD (1) · Amira R AL-Agooz (1) · Ana Cristina Solis, PhD (1) · Cassiano K Rosing, DDS, PhD (1) · Cristiano Susin, DDS, PhD (1) · Fernando Gerchman, PhD (1) · Francisco Lotufo-Neto, PhD (1) · Ghada Almuqayad, BDS (1) · Hacer Sahin Aydinyurt, Assist Prof (1) · Mariano Sanz (1) · Mariely Navarrete Riffo, MSc (1) · Marinele R Campos, DDS (1) · Priscila P Costa, PhD (1)
PMID 10052767, PMID 12694427, PMID 14584861, PMID 15157814, PMID 15330942, PMID 15341364, PMID 15562916, PMID 15691340, PMID 16268999, PMID 17539717, PMID 17891261, PMID 19508270, PMID 22348135, PMID 22420873, PMID 22935673, PMID 22935674, PMID 23389686, PMID 23574468, PMID 23952266, PMID 25858047, PMID 26461465, PMID 26847598, PMID 28549330, PMID 2885745, PMID 32436173, PMID 8844930
2008 (1)