973 completed, 253 unknown, 157 terminated, 98 recruiting. 439 Not applicable, 416 Phase 2, 390 Phase 4, 244 Phase 1, 243 Phase 3.
Follow Saline: new trials by email Literature Review of Saline trials Research Report on Saline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| Role of Inhaled Polymyxin as an Adjunct to Intravenous Therapy in Multidrug Resistant Ventilator-associated Pneumonia in Stroke Patients Inhaled colistin, Saline - Ventilator Associated Pneumonia ( VAP) | Early Phase 1 | Not yet recruiting | Ain Shams University | 78 | 2026-10-10 | 2026-10-08 |
| The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans Exendin 9-39, Saline - Genetic Predisposition, Type2diabetes | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-10-01 | 2026-01-30 |
| Intrauterine G-CSF Infusion for Thin Endometrium Granulocyte Colony-Stimulating Factor(G-CSF), Normal Saline - Thin Endometrium, Female Infertility | Phase 3 | Not yet recruiting | Nanjing University | 620 | 2026-10-01 | 2026-07-09 |
| Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 80 | 2026-10-01 | 2026-09-24 |
| Botulinum Toxin Blockade of Neuronal Signals to Immune Cells as a Novel Treatment for Hidradenitis Suppurativa Botulinum Toxin A (Allergan, Inc, Irvine CA), Placebo - Hidradenitis Suppurativa (HS) | Phase 2 | Not yet recruiting | University of Massachusetts, Worcester | 40 | 2026-10-01 | 2026-09-10 |
| Safety and Immunogenicity of Chimeric Hemagglutinin mRNA Vaccine Candidates cH15/3, cH4/3, cH5/1N1 - Influenza | Phase 1 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 60 | 2026-09-18 | 2026-10-16 |
| Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment Lidocaine (drug), Saline - Refractory Migraine, Headache | Phase 2 | Recruiting | Daniel A Tonetti, MD | 80 | 2026-09-09 | 2026-10-01 |
| Evaluation of Lacrifill Lacrifill, Saline - Dry Eye, Ocular Surface Disease | Phase 4 | Recruiting | Eye Research Associates, LLC | 40 | 2026-09-02 | 2026-09-25 |
| Platform Trial in Stage 1 Diabetes: Comparing Golimumab vs Placebo Golimumab, Placebo (matching golimumab) - Type 1 Diabetes (T1D) | Phase 2 | Not yet recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 255 | 2026-08-08 | 2026-07-06 |
| Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy Saline, Tramadol, Tramadol + Dexamethasone - Knee Arthroscopy, Postoperative Pain | Phase 4 | Not yet recruiting | Arzu Esen Tekeli | 135 | 2026-07-15 | 2026-05-14 |
| Investigating the Clinical Benefits and Underlying Mechanisms of Danhong Injection in Modulating Mitochondrial Homeostasis Against Sepsis-Associated Myocardial Dysfunction Danhong injection, Saline - Sepsis-Induced Myocardial Dysfunction | Phase 2 | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 140 | 2026-07-01 | 2026-01-29 |
| Subcutaneous Calcitonin in Acute Herpes Zoster Calcitonin, Saline - Calcitonin, Subcutaneous | Phase 3 | Recruiting | Tanta University | 168 | 2026-07-01 | 2026-07-06 |
| Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement Ketorolac, oral ibuprofen, Placebo - Pain Management, Abortion | Phase 2 | Recruiting | Rush University Medical Center | 76 | 2026-06-29 | 2026-07-06 |
| Efficacy and Safety Study of TPX-115 on Partial-thickness Rotator Cuff Tear TPX-115, Cryopreserving hyaluronic acid medium, Saline - Partial Thickness Rotator Cuff Tears | Phase 2 | Recruiting | Tego Science, Inc. | 60 | 2026-06-09 | 2026-06-18 |
| TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis TP04HN106, Saline - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Talengen Institute of Life Sciences, Shenzhen, P.R. China. | 60 | 2026-06-04 | 2026-10-02 |
| Packed Red Blood Cell Transfusion During Cardiac Arrest Packed Red Blood Cells (1 unit), Packed Red Blood Cells (2 units), Saline - Cardiac Arrest | Phase 1 | Suspended | NYU Langone Health | 30 | 2026-06-01 | 2026-04-09 |
| Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy Ropivacaine, Saline - Rectus Sheath Block, Transversus Abdominis Plane Block | Phase 4 | Not yet recruiting | Tri-Service General Hospital (TSGH) | 90 | 2026-06-01 | 2026-06-03 |
| Workflow Optimization During Pulse Field Ablation for Atrial Fibrillation lidocaine, Saline - Pulsed Field Ablation, Lidocaine | Phase 4 | Not yet recruiting | National Taiwan University Hospital | 60 | 2026-06-01 | 2026-04-20 |
| Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery Dexmedetomidine, Saline - New Onset, Atrial Fibrillation | Not applicable | Not yet recruiting | Ain Shams University | 140 | 2026-06-01 | 2026-03-19 |
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Pain, Postoperative (112) · Pain (74) · Agnosia (45) · Obesity (41) · Osteoarthritis, Knee (39) · Osteoarthritis (30) · COVID-19 (28) · Diabetes Mellitus, Type 2 (23) · Insulin Resistance (23) · Postoperative Nausea and Vomiting (20) · Migraine Disorders (19) · Breast Neoplasms (17) · Diabetes Mellitus (16) · Hemorrhage (16) · Acute Kidney Injury (14)
Assiut University (22) · Cairo University (19) · Yonsei University (16) · Mayo Clinic (15) · University of Aarhus (15) · Vanderbilt University Medical Center (15) · Ain Shams University (14) · Pfizer (14) · Danish Headache Center (13) · Northwestern University (13) · Tanta University (13) · Icahn School of Medicine at Mount Sinai (12) · Wake Forest University Health Sciences (12) · Johns Hopkins University (11) · University Hospital, Gentofte, Copenhagen (11)
United States (660) · China (128) · Denmark (118) · Egypt (97) · Canada (94) · United Kingdom (60) · Turkey (Türkiye) (57) · South Korea (43) · Germany (40) · Brazil (33) · Israel (33) · Australia (29) · Spain (27) · Netherlands (25) · Sweden (24)
Adrian Vella, MD (6) · David H Barad, MD, MS (4) · Norbert Gleicher, MD (4) · Ulrik Grevstad, MD (4) · Alexander Kolevzon, MD (3) · Daniel I Sessler, MD (3) · Dariush Elahi, PhD (3) · Filip K Knop, MD, PhD (3) · Howard Levy, M.D. (3) · Howard Levy, MD (3)
PMID 39903535, PMID 32031570, PMID 32171076, PMID 29515037, PMID 33238043, PMID 39428602, PMID 17180268, PMID 18633034, PMID 19404806, PMID 20920772, PMID 23053510, PMID 24026316, PMID 28284978, PMID 28286967, PMID 29156068, PMID 32681472, PMID 32941801, PMID 34677593, PMID 34870327, PMID 35164991, PMID 38987318, PMID 39607014, PMID 42159953, PMID 10219875, PMID 10403850, PMID 10526739, PMID 10534247, PMID 10582782, PMID 10625862, PMID 106465, PMID 10691234, PMID 10776835, PMID 10782451, PMID 10886700, PMID 10910490, PMID 10910857, PMID 10998650, PMID 11020770, PMID 11150359, PMID 11202234, PMID 11426893, PMID 11873026, PMID 12082670, PMID 12098173, PMID 12114906, PMID 12219057, PMID 12222941, PMID 12771261, PMID 12826855, PMID 12841893
2017 (10), 2014 (7), 2015 (6), 2016 (6), 2009 (4), 2018 (4), 2019 (4), 2008 (3), 2023 (3), R01DA010017 (3), R01DK126206 (3), UL1RR024150 (3), M01RR000070 (2), M01RR000750 (2), M01RR000997 (2)