6 completed, 2 not yet recruiting, 2 terminated, 1 recruiting. 11 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 6, Not yet recruiting 2, Terminated 2, Recruiting 1 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
Follow S-Adenosylmethionine: new trials by email Literature Review of S-Adenosylmethionine trials Research Report on S-Adenosylmethionine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| SAMe for Prevention of Liver Cancer in MASLD-Related Cirrhosis S-adenosyl-L-methionine (SAMe), Placabo - Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 94 | 2026-04-15 | 2026-03-31 |
| SAMe Trial for Patients With Alcoholic Cirrhosis Placebo, SAMe 400 mg tablet - Alcoholic Cirrhosis | Phase 2 | Recruiting | Indiana University | 196 | 2020-10-22 | 2026-03-31 |
| Poly-ICLC (Hiltonol) and Anti-PD1 or Anti-PD-L1 Poly-ICLC combination treatment with aPD-1 (Nivolumab or Pembrolizumab) or aPD-L1 (Atezolizumab or Durvalumab) over 6 months - Solid Cancer | Phase 1 / Phase 2 | Terminated | Oncovir, Inc. | 7 | 2018-09-25 | 2021-02-01 |
| S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence S-Adenosyl-L-Methionine, placebo - Tobacco Dependence | Phase 2 / Phase 3 | Completed | Mayo Clinic | 150 | 2008-09-01 | 2011-09-09 |
| S-Adenosyl Methionine (SAMe) to Treat Patients With Chronic Hepatitis C Peginterferon alfa-2a, Ribavirin, S-adenosyl methionine for Chronic Liver Disease - Chronic Hepatitis C | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 24 | 2007-05-01 | 2013-07-05 |
| Efficacy of S-Adenosylmethionine in Fibromyalgia SAM-e (S-Adenosyl-L-Methionine) - Fibromyalgia Syndrome | Phase 2 | Completed | Deakin University | 70 | 2006-11-01 | 2007-09-12 |
| Tobacco Cessation Treatment for Pregnant Alaska Natives Standard intervention (counseling + self-help written materials), Enhanced Intervention (same as standard treatment plus 10-15 min of counseling and a culturally tailored video) - Tobacco Use | Phase 1 / Phase 2 | Completed | Mayo Clinic | 35 | 2006-11-01 | 2012-03-09 |
| Chronic Hepatitis C Non-Responder Study With AdoMet and Betaine S-adenosyl-L-methionine, betaine, pegylated interferon alpha2b - Hepatitis C | Phase 2 / Phase 3 | Completed | University Hospital, Basel, Switzerland | 30 | 2006-08-01 | 2010-10-28 |
| SAMe to Treat Biliary Cirrhosis Symptoms S-adenosyl-methionine (SAMe) capsules - Liver Cirrhosis, Biliary | Phase 2 | Terminated | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 50 | 2005-07-25 | 2017-07-02 |
| SAM-e for the Treatment of Depression in Patients With Parkinson's Disease SAM-e, oral escitalopram, placebo - Parkinson's Disease, Depression | Phase 2 / Phase 3 | Completed | NYU Langone Health | 29 | 2003-07-01 | 2016-07-13 |
Hepatitis C (2) · Tobacco Use (2) · Chemical and Drug Induced Liver Injury (1) · Colorectal Neoplasms (1) · Depression (1) · Fatigue (1) · Fibromyalgia (1) · Fibrosis (1) · Hemolysis (1) · Hepatic Veno-Occlusive Disease (1) · Hepatitis C, Chronic (1) · Liver Cirrhosis, Alcoholic (1) · Liver Cirrhosis, Biliary (1) · Liver Diseases (1) · Parkinson Disease (1)
Cedars-Sinai Medical Center (2) · Mayo Clinic (2) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2) · Deakin University (1) · Indiana University (1) · NYU Langone Health (1) · Oncovir, Inc. (1) · University Hospital, Basel, Switzerland (1)
United States (8) · Australia (1) · Switzerland (1)
Alessandro Di Rocco, MD (1) · Alexandra Gangi, MD (1) · Amit Sood, M.D. (1) · Christi A Patten, P (1) · David H Smith, MD (1) · Frederick P Smith, MD (1) · Gregory A Tooley, PhD (1) · Jay Hoofnagle, MD (1) · Markus H Heim, MD (1) · Nina Bhardwaj, MD, PhD (1) · Suthat Liangpunsakul, MD (1)
PMID 14639532, PMID 20697067, PMID 20854821, PMID 21079746, PMID 22065672, PMID 37230961
R01AT000941 (1), R01DA025156 (1), U01AA026817 (1)