37 completed, 2 terminated, 2 unknown, 1 active not recruiting. 25 Phase 3, 7 Phase 4, 5 Phase 2, 3 Phase 1, 2 Not applicable.
Follow Rotavirus Vaccines: new trials by email Literature Review of Rotavirus Vaccines trials Research Report on Rotavirus Vaccines
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants Pentavalent Meningococcal ABCYW vaccine, MenACYW conjugate vaccine, Meningococcal group B vaccine - Meningococcal Immunization, Healthy Volunteers | Phase 1 / Phase 2 | Active not recruiting | Sanofi Pasteur, a Sanofi Company | 750 | 2024-11-05 | 2026-01-20 |
| Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers RSVt vaccine, Diphtheria, tetanus, pertussis, poliomyelitis , Haemophilus influenzae type b, and hepatitis B vaccine, Diphtheria, tetanus, pertussis, Haemophilus influenzae type b and poliomyelitis vaccine - RSV Immunization | Phase 3 | Terminated | Sanofi Pasteur, a Sanofi Company | 2226 | 2024-05-13 | 2026-10-05 |
| Study of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Given With Routine Pediatric Vaccines in Healthy Infants and Toddlers in India and the Republic of South Africa Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine, Meningococcal (Groups A, C, Y and W 135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Oral bivalent types 1 and 3; Poliomyelitis Vaccine (OPV) - Meningococcal Immunisation, Healthy Volunteers | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 1528 | 2023-03-27 | 2026-01-21 |
| A Surveillance Study on Timing and Coverage Of Rotavirus and MenB Vaccine Co-administration in Campania Region, Italy Rotavirus Vaccine - Vaccination, Rotavirus Infections | Unknown | Federico II University | 2000 | 2022-05-01 | 2022-03-17 | |
| Immunogenicity and Safety of Concomitant and Non-Concomitant Administration of RotaTeq® (V260) and Inactivated Poliomyelitis Vaccine in Healthy Chinese Infants (V260-074) RotaTeq (V260), IPV - Prevention of Rotavirus Gastroenteritis in Infants and Children Caused by Serotypes G1, G2, G3, G4, and G9 | Phase 3 | Completed | Merck Sharp & Dohme LLC | 400 | 2020-08-25 | 2024-07-26 |
| Study of a Pneumococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Toddlers and Infants Pneumococcal Conjugate Vaccine formulation 1, Pneumococcal Conjugate Vaccine formulation 2, Pneumococcal Conjugate Vaccine formulation 3 - Pneumococcal Immunisation, Diphtheria Immunisation | Phase 2 | Completed | Sanofi Pasteur, a Sanofi Company | 852 | 2020-05-22 | 2025-09-08 |
| Development of a Live Attenuated Rotavirus Vaccine as a Human Infection Challenge Model Rotavirus vaccine - Diarrhoeal Disease | Not applicable | Completed | Centre for Infectious Disease Research in Zambia | 22 | 2019-01-22 | 2019-10-14 |
| A Study to Evaluate the Interchangeability of V114 and Prevnar 13™ in Healthy Infants (V114-027/PNEU-DIRECTION) Prevnar 13™, V114, RotaTeq™ - Pneumococcal Infections | Phase 3 | Completed | Merck Sharp & Dohme LLC | 900 | 2018-10-18 | 2023-01-17 |
| Safety and Immunogenicity of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the Russian Federation and Mexico Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus Toxoid Conjugate Vaccine, Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Measles, Mumps, and Rubella Virus Vaccine Live - Healthy Volunteers (Meningococcal Infection) | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 525 | 2018-10-17 | 2023-10-19 |
| Immunogenicity and Safety Study of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers Meningococcal Polysaccharide (Serogroups A,C,Y and W) Tetanus Toxoid Conjugate vaccine MenACYW conjugate vaccine, Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Meningococcal Polysaccharide (serogroups A,C,Y and W-135) Diphtheria Toxoid Conjugate Vaccine - Healthy Volunteers (Meningococcal Infection) | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 950 | 2018-10-04 | 2024-06-25 |
| Safety of a Quadrivalent Meningococcal Conjugate Vaccine Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers Meningococcal polysaccharide (serogroups A,C,Y and W) tetanus toxoid Conjugate vaccine (MenACYW Conjugate vaccine), Meningococcal (Groups A, C, Y and W 135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine (MENVEO®), Diphtheria, Tetanus, Acellular Pertussis, Poliovirus and Haemophilus b Vaccine - Healthy Volunteers (Meningococcal Infection) | Phase 3 | Completed | Sanofi Pasteur, a Sanofi Company | 2797 | 2018-09-17 | 2023-12-14 |
| Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study Rotarix®,, Rotarix®, with other routine vaccines, RotaTeq®, - Intussusception, Rotavirus Infections | Phase 4 | Completed | Children's Hospital Medical Center, Cincinnati | 144 | 2015-11-01 | 2018-07-12 |
| The Role of the Intestinal Microbiome in Enteric and Systemic Vaccine Immune Responses Rotavirus vaccine, Tetanus vaccine and Pneumococcal vaccine - Rotavirus Infections, Intestinal Bacteria Flora Disturbance | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 63 | 2015-09-01 | 2017-07-25 |
| Baby Vaccine Study (Sched3) DTaP/IPV/Hib vaccine, 13 valent Pneumococcal Conjugate Vaccine, Rotavirus vaccine - Infectious Diseases | Phase 2 | Completed | University of Oxford | 189 | 2015-08-01 | 2021-09-20 |
| Efficacy and Safety of a Pentavalent Rotavirus Vaccine (BRV-PV) Against Severe Rotavirus Gastroenteritis in Niger Rotavirus vaccine (BRV-PV), Placebo - Severe Rotavirus Gastroenteritis | Phase 3 | Completed | Epicentre | 6586 | 2014-06-01 | 2023-09-22 |
| Efficacy, Safety, and Immunogenicity of V260 in Healthy Chinese Infants (V260-024) V260, Placebo to V260, OPV - Rotavirus Gastroenteritis | Phase 3 | Completed | Merck Sharp & Dohme LLC | 4040 | 2014-05-30 | 2018-11-27 |
| The Safety and Immunogenicity Study of Rotavirus Vaccine Simultaneously Vaccinated With MR or MMR Vaccine rotavirus vaccine, measles-rubella vaccine, measles-mumps-rubella vaccine - Rotavirus | Phase 4 | Unknown | Sichuan Center for Disease Control and Prevention | 2800 | 2013-12-01 | 2014-06-03 |
| Immunogenicity and Safety of Concomitant Administration of RotaTeq™ (V260) and the Diphtheria, Tetanus, Pertussis and Inactivated Poliovirus Vaccine (DTP-IPV) in Healthy Japanese Infants (V260-060) RotaTeq™ (V260), DTP-IPV - Rotavirus Disease | Phase 4 | Completed | Merck Sharp & Dohme LLC | 192 | 2013-09-19 | 2018-11-14 |
| A Study of the Immunogenicity, Tolerability, and Safety of a New Formulation of RotaTeq™ in Infants (V260-035) RotaTeq™ experimental formulation, RotaTeq™ existing formulation - Rotavirus Gastroenteritis | Phase 3 | Completed | Merck Sharp & Dohme LLC | 1020 | 2013-04-29 | 2018-11-14 |
| Coadministration of Measles-rubella and Rotavirus Vaccines Rotarix vaccine, measles-rubella vaccine - Measles Antibody Seroconversion, Rubella Antibody Seroconversion | Phase 4 | Completed | PATH | 482 | 2013-01-01 | 2019-03-13 |
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Rotavirus Infections (14) · Meningococcal Infections (5) · Gastroenteritis (4) · Tetanus (4) · Diarrhea (3) · Diphtheria (3) · Poliomyelitis (3) · Whooping Cough (3) · Bacterial Infections (2) · Haemophilus Infections (2) · Hepatitis B (2) · Virus Diseases (2) · Breast Feeding (1) · Communicable Diseases (1) · Fever (1)
Merck Sharp & Dohme LLC (19) · Sanofi Pasteur, a Sanofi Company (8) · PATH (3) · GlaxoSmithKline (2) · International Centre for Diarrhoeal Disease Research, Bangladesh (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Butantan Institute (1) · Centre for Infectious Disease Research in Zambia (1) · Children's Hospital Medical Center, Cincinnati (1) · Epicentre (1) · Federico II University (1) · MCM Vaccines B.V. (1) · Sichuan Center for Disease Control and Prevention (1) · University of Oxford (1)
United States (7) · Puerto Rico (5) · Bangladesh (3) · Brazil (2) · Czechia (2) · Finland (2) · Germany (2) · Honduras (2) · India (2) · Mexico (2) · South Africa (2) · Spain (2) · United Kingdom (2) · Canada (1) · China (1)
Alexander R Precioso, MD,PhD (1) · Alfredo Gilio, MD (1) · Andrea Lo Vecchio, MD, PhD (1) · Edson Moreira, MD, PhD (1) · Gagandeep Kang, MD, PhD (1) · K Zaman, MBBS, PhD (1) · K Zaman, PhD, MPH (1) · Karen Broder, MD (1) · Mary A. Staat, MD, MPH (1) · Matthew D Snape (1)
PMID 16394299, PMID 18174862, PMID 18756184, PMID 19209092, PMID 20540778, PMID 20692030, PMID 20692031, PMID 21389149, PMID 23442588, PMID 23732903, PMID 26035743, PMID 26823338, PMID 27288217, PMID 27755463, PMID 28140752, PMID 28141698, PMID 28328346, PMID 28419095, PMID 28935470, PMID 29564996, PMID 29752026, PMID 30808567, PMID 32153947, PMID 33109390, PMID 33428870, PMID 34214095, PMID 34375336, PMID 34548050, PMID 35144847, PMID 35500028, PMID 36522265, PMID 38509699, PMID 41489614, PMID 41792337, PMID 42642862
2019 (2), 2018 (1), 2023 (1)