13 completed, 5 terminated, 3 unknown, 3 withdrawn. 12 Phase 4, 9 Phase 2, 3 Not applicable, 3 Phase 3, 2 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide Fosaprepitant for Injection, Metoclopramide Injection - Nausea and Vomiting, Nausea | Phase 4 | Not yet recruiting | Montefiore Medical Center | 212 | 2026-12-01 | 2026-06-29 |
| Time to First Rescue Antiemetic With Ondansetron Plus Metoclopramide Versus Dexamethasone Plus Metoclopramide for PONV Prophylaxis in Laparoscopic Cholecystectomy ondansetron 4 mg, Dexamethasone (intravenous), Metoclopramide 10mg - Postoperative Nausea and Vomiting | Phase 4 | Recruiting | Faisalabad Medical University | 264 | 2026-09-01 | 2026-09-04 |
| Metoclopramide in Upper Gastrointestinal Bleed Metoclopramide 10mg, Saline - Upper GI Bleeding, Bleeds Gastric | Phase 4 | Unknown | Mercy Health System | 60 | 2023-05-20 | 2023-07-11 |
| Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy Capsaicin Topical Cream, Metoclopramide, Ondansetron - Hyperemesis Gravidarum, Nausea Gravidarum | Phase 2 | Completed | Women and Infants Hospital of Rhode Island | 30 | 2022-05-24 | 2024-02-07 |
| PROUD Study - Preventing Opioid Use Disorders Guided mindfulness exercises, Self-administered aromatherapy, Baby aspirin - Anesthesia, Opioid Use | Phase 4 | Terminated | Emory University | 57 | 2021-05-17 | 2023-06-22 |
| Metoclopramide Versus Placebo for GJ Placement Metoclopramide 5 MG/ML Injectable Solution, Saline - Radiation Exposure, Enteral Nutrition | Phase 2 | Completed | Duke University | 110 | 2018-04-09 | 2020-07-13 |
| Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy Aprepitant 80 mg Oral Capsule, scopolamine transdermal, Total intravenous anesthesia - Post-operative Nausea and Vomiting, Laparoscopic Sleeve Gastrectomy | Phase 4 | Completed | Stony Brook University | 83 | 2017-08-28 | 2024-02-14 |
| Metoclopramide for Post-Traumatic Headache. A Pilot Study Metoclopramide, Diphenhydramine - Post-Traumatic Headache | Phase 1 / Phase 2 | Completed | Montefiore Medical Center | 21 | 2017-03-01 | 2018-07-31 |
| Study to Evaluate the Effect of Aprepitant in Children and Adolescents Receiving AML Remission Induction Chemotherapy Aprepitant, Ondansetron, Metoclopramide - Chemotherapy Induced Vomiting, Acute Myeloid Leukemia | Phase 3 | Unknown | Dr Atul Sharma | 116 | 2016-11-01 | 2017-01-25 |
| Auricular Acupuncture vs SOC in Migraine HA Auricular Acupuncture, Ketorolac 0.5mg/kg, max 30mg, Metoclopramide 0.1 mg/kg, max 10mg - Migraine Headache | Not applicable | Unknown | University of Louisville | 80 | 2016-02-01 | 2023-10-10 |
| Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean Acupressure Point P6 stimulator, Metoclopramide, Ondansetron - Nausea, Vomiting | Phase 4 | Completed | Rutgers, The State University of New Jersey | 180 | 2015-07-01 | 2017-09-25 |
| PEP uP Protocol in Surgical Patients PEP uP Protocol, Metoclopramide - Critically Ill | Phase 4 | Terminated | Clinical Evaluation Research Unit at Kingston General Hospital | 36 | 2015-07-01 | 2020-10-27 |
| Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum Gabapentin, Metoclopramide - Hyperemesis Gravidarum | Phase 2 | Completed | State University of New York at Buffalo | 31 | 2014-06-01 | 2023-02-14 |
| Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department Metoclopramide, Haloperidol, Normal Saline - Headache, Migraine | Phase 4 | Terminated | OhioHealth | 66 | 2014-02-01 | 2018-10-23 |
| Bupivacaine for Benign Headache in the ED 0.5% bupivacaine, Standard Care - Benign Headache | Phase 2 | Terminated | Wake Forest University Health Sciences | 23 | 2013-10-01 | 2022-07-14 |
| TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas TRC102, CT scan, Lomotil - Lymphomas, Solid Tumors | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 93 | 2013-07-12 | 2024-05-08 |
| Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT Haloperidol, Metoclopramide 10mg, Diphenhydramine - Migraine Headaches, Nausea | Phase 4 | Withdrawn | United States Naval Medical Center, Portsmouth | 2013-06-12 | 2025-07-29 | |
| Diphenhydramine for Acute Migraine metoclopramide, diphenhydramine, placebo - Migraine | Phase 4 | Completed | Montefiore Medical Center | 208 | 2013-04-01 | 2018-07-31 |
| Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness Ibuprofen, Metoclopramide - Acute Mountain Sickness, High Altitude Headache | Not applicable | Completed | Massachusetts General Hospital | 300 | 2012-03-01 | 2020-09-02 |
| Intravenous Ketorolac and Metoclopramide for Pediatric Migraine in the Emergency Department Ketorolac Tromethamine, Metoclopramide - Probable Migraine, Migraine With Aura | Phase 4 | Completed | University of Alberta | 56 | 2012-02-01 | 2015-01-26 |
Showing 20 of 26. Sign in to see all of them.
Migraine Disorders (7) · Nausea (5) · Vomiting (5) · Headache (4) · Hyperemesis Gravidarum (2) · Altitude Sickness (1) · Colonic Neoplasms (1) · Critical Illness (1) · Diabetes Mellitus (1) · Emergencies (1) · Feeding and Eating Disorders (1) · Gastrointestinal Hemorrhage (1) · Gastroparesis (1) · Hemorrhage (1) · Leukemia, Myeloid, Acute (1)
Montefiore Medical Center (4) · Women and Infants Hospital of Rhode Island (2) · Children's Hospital of Philadelphia (1) · Clinical Evaluation Research Unit at Kingston General Hospital (1) · Dr Atul Sharma (1) · Duke University (1) · East Tennessee State University (1) · Emory University (1) · Evoke Pharma (1) · Faisalabad Medical University (1) · Massachusetts General Hospital (1) · Mercy Health System (1) · Michael Dean (1) · National Cancer Institute (NCI) (1) · OhioHealth (1)
United States (22) · Canada (1) · India (1) · Nepal (1) · Pakistan (1)
Alice P Chen, M.D. (1) · Asifa Saeed, MBBS; FCPS (1) · Benjamin Friedman, MD (1) · Benjamin W Friedman (1) · Carey Nichols, MD (1) · Christopher Lloyd, D.O. (1) · Daren K Heyland, MD (1) · Darshan S Shah, MD (1) · James Ronald (1) · Janice Sullivan, MD (1) · Joseph Carcillo, MD (1) · Konstantinos Spaniolas, MD (1) · Lauren Murphy, MD (1) · Lawrence P. Richer, MD, MSc (1) · Matthew Gaffigan, MD (1)
PMID 22079954, PMID 23567060, PMID 25576687, PMID 26320523, PMID 32457012, PMID 33122168, PMID 33451591, PMID 33528788, PMID 34002866, PMID 37271593
R01HD076313 (1)