5 completed, 4 active not recruiting, 3 recruiting, 3 unknown. 21 Phase 1, 13 Phase 2.
Follow Radiation Dose Hypofractionation: new trials by email Literature Review of Radiation Dose Hypofractionation trials Research Report on Radiation Dose Hypofractionation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypofractionated Radiotherapy Plus Immunochemotherapy for Neoadjuvant Treatment of Gastroesophageal Junction Adenocarcinoma hypofractionated radiotherapy, PD-1 inhibitor, TS-1 - Gastroesophageal Junction Adenocarcinoma, Hypofractionated Radiotherapy | Phase 1 / Phase 2 | Recruiting | West China Hospital | 84 | 2025-11-18 | 2026-01-06 |
| Hypofractionated Radiotherapy Combined With Immunochemotherapy for Conversion Treatment of Gastroesophageal Junction Adenocarcinoma hypofractionated radiotherapy, SOX Chemotherapy, PD-1 inhibitor - Gastroesophageal Junction Adenocarcinoma, Hypofractionated Radiotherapy | Phase 1 / Phase 2 | Recruiting | West China Hospital | 88 | 2025-09-15 | 2025-11-28 |
| HYpofractionated Pelvic Radiotherapy for Advanced Cervical Cancers INeligible for ChemoTherapy Hypofractionation - Locally Advanced Cervical Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | University of Santo Tomas Hospital, Philippines | 55 | 2024-01-01 | 2023-01-31 |
| Combining ICI With SBRT or HypoFrx-RT for ES NSCLC Stereotactic body radiotherapy, Hypofractionated radiotherapy, Durvalumab - Non-small Cell Lung Cancer, Non-small Cell Carcinoma | Phase 1 / Phase 2 | Unknown | Alexander Chi | 83 | 2023-10-09 | 2023-10-03 |
| Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer Carboplatin, Durvalumab, Paclitaxel - Locally Advanced Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 28 | 2021-12-06 | 2026-06-30 |
| Hypofractionated Radiation Therapy and Bintrafusp Alfa for the Treatment of Advanced Intrahepatic Cholangiocarcinoma Bintrafusp Alfa, Biopsy, Hypofractionated Radiation Therapy - Locally Advanced Intrahepatic Cholangiocarcinoma, Metastatic Intrahepatic Cholangiocarcinoma | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 2 | 2021-08-31 | 2026-09-14 |
| Fraction Dose Escalation of Hypo-fractionated Radiotherapy in LANSCLC Hypofractionated radiotherapy, Concurrent chemotherapy, Consolidation immunotherapy - Locally Advanced Lung Carcinoma | Phase 1 | Completed | Sun Yat-sen University | 18 | 2021-06-01 | 2023-12-15 |
| Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer Hypofractionated Radiation, Clinical Follow-Up and Assessments - Endometrial Cancer | Phase 1 / Phase 2 | Suspended | University of Chicago | 100 | 2021-01-15 | 2026-09-10 |
| Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Pancreatic Adenocarcinoma, Stage III Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Suspended | National Cancer Institute (NCI) | 92 | 2021-01-11 | 2026-10-20 |
| BreastVAX: Radiation Boost to Enhance Immune Checkpoint Blockade Therapy Hypofractionated radiotherapy, Pembrolizumab infusion, Blood and tissue sampling - Breast Cancer | Phase 1 / Phase 2 | Active not recruiting | Abramson Cancer Center at Penn Medicine | 27 | 2020-12-07 | 2026-03-10 |
| Sintilimab Plus Hypofractionated Radiotherapy for MSI-H/dMMR Rectal Cancer Sintilimab, Hypofractionated Radiotherapy - Anti-PD-1 Antibody, Radiotherapy | Phase 1 / Phase 2 | Unknown | West China Hospital | 20 | 2020-08-14 | 2024-08-06 |
| Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies Avelumab, Biopsy Procedure, Biospecimen Collection - Locally Advanced Malignant Solid Neoplasm, Locally Advanced Unresectable Cholangiocarcinoma | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 103 | 2020-04-07 | 2026-10-02 |
| Losartan and Hypofractionated Rx After Chemo for Tx of Borderline Resectable or Locally Advanced Pancreatic Cancer Hypofractionated Radiation Therapy, Losartan, Losartan Potassium - Borderline Resectable Pancreatic Adenocarcinoma, Locally Advanced Pancreatic Ductal Adenocarcinoma | Phase 1 | Completed | University of Utah | 22 | 2019-08-08 | 2026-07-06 |
| Phase I Multicenter Trial Combining Nivolumab, Ipilimumab and Hypo-fractionated Radiotherapy for Pretreated Advanced Stage Non-small Cell Lung Cancer Patients hypofractionated radiotherapy, nivolumab, Ipilimumab - Non-small Cell Lung Cancer | Phase 1 | Terminated | Assistance Publique Hopitaux De Marseille | 6 | 2018-06-07 | 2023-06-15 |
| RADVAX™: A Trial of Combined Pembrolizumab and Hypofractionated Radiation in Patients With Advanced Urothelial Cancer Who Have Progressed on Anti-PD-1/PD-L1 Monotherapy PEMBROLIZUMAB, hypofractionated radiation - Urothelial Cancer | Phase 1 | Withdrawn | Abramson Cancer Center at Penn Medicine | 2016-08-01 | 2019-04-23 | |
| Study of REGN2810 (Anti-PD-1) in Patients With Advanced Malignancies Cemiplimab, Hypofractionated radiotherapy, Cyclophosphamide - Advanced Cancer, Advanced Malignancies | Phase 1 | Completed | Regeneron Pharmaceuticals | 398 | 2015-02-02 | 2020-01-27 |
| Hypofractionated Reduced-Volume Chemoradiation for T1/2N0-2 SCC Head and Neck Intensity Modulated Radiotherapy - Squamous Cell Carcinoma of the Head and Neck T1/2N0-2 | Phase 1 | Terminated | University of Texas Southwestern Medical Center | 8 | 2014-09-18 | 2021-02-02 |
| A Study Using Radiation Therapy and Temozolomide to Treat Glioblastoma in Patients Over 70 Hypofractionated radiotherapy, Temozolomide - Glioblastoma | Phase 1 / Phase 2 | Active not recruiting | University of Louisville | 18 | 2014-09-01 | 2024-10-31 |
| Safety and Efficacy Study of Hypofractionated Radiotherapy and Androgen Deprivation Therapy for Prostate Cancer Hypofractionated radiation - Prostate Cancer | Phase 1 / Phase 2 | Unknown | Sunnybrook Health Sciences Centre | 30 | 2011-09-01 | 2020-11-24 |
| Safety and Efficacy Study of Dose-escalated Hypofractionated Radiotherapy For Prostate Cancer Hypofractionated radiotherapy - Prostate Cancer | Phase 1 / Phase 2 | Completed | Sunnybrook Health Sciences Centre | 30 | 2010-05-01 | 2019-10-04 |
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Prostatic Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (2) · Cholangiocarcinoma (2) · Pancreatic Neoplasms (2) · Breast Neoplasms (1) · Endometrial Neoplasms (1) · Gallbladder Neoplasms (1) · Glioblastoma (1) · Head and Neck Neoplasms (1) · Lung Neoplasms (1) · Neoplasm Metastasis (1) · Rectal Neoplasms (1) · Turcot syndrome (1)
West China Hospital (3) · Abramson Cancer Center at Penn Medicine (2) · National Cancer Institute (NCI) (2) · Sunnybrook Health Sciences Centre (2) · Alberta Health services (1) · Alexander Chi (1) · Assistance Publique Hopitaux De Marseille (1) · M.D. Anderson Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Regeneron Pharmaceuticals (1) · Sun Yat-sen University (1) · University of Chicago (1) · University of Louisville (1) · University of Santo Tomas Hospital, Philippines (1) · University of Texas Southwestern Medical Center (1)
United States (11) · China (5) · Canada (3) · Australia (1) · France (1) · Spain (1)
Alexander Chi, MD (1) · Andrew Loblaw, MD (1) · Andrew Loblaw, MD, FRCPC (1) · Christina Son, MD (1) · Eugene J Koay (1) · Harvey Quon, MD (1) · Hui Liu, Professor (1) · Jeremey Brownstein, MD (1) · John Christodouleous, MD (1) · Julia C Tchou, MD (1) · Kristen R Spencer (1) · Lucien Nedzi, MD (1) · Meng Qiu, M.D. (1) · Robert Pearcey, MD (1)
PMID 27622157, PMID 27879972, PMID 29863979, PMID 32554615, PMID 33831732, PMID 33942954, PMID 35352512
2015 (1), 2017 (1), R01CA262388 (1), UM1CA186644 (1), UM1CA186691 (1), UM1CA186716 (1)