22 completed, 5 terminated, 3 withdrawn, 2 not yet recruiting. 34 Phase 2, 5 Phase 3, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 34 | Completed 22, Terminated 5, Withdrawn 3, Not yet recruiting 2, Unknown 2 |
| Phase 3 | 5 | Completed 2, Unknown 2, Terminated 1 |
| Phase 1 | 4 | Completed 4 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya 5% 5-fluorouracil Topical Cream, Placebo Cream - HIV Infections, HPV Infection | Phase 2 | Not yet recruiting | UNC Lineberger Comprehensive Cancer Center | 140 | 2026-09-01 | 2026-08-27 |
| Efficacy and Safety of Benvitimod Cream in Cutaneous T-Cell Lymphoma Benvitimod Cream, Placebo cream - Cutaneous T-Cell Lymphoma, Mycosis Fungoides (MF) | Phase 2 | Not yet recruiting | Peking University First Hospital | 35 | 2026-07-01 | 2026-06-22 |
| Ivermectin Safety in Small Children Oral ivermectin, Permethrin Cream, Placebo tablet - Scabies | Phase 2 | Completed | University of Oxford | 240 | 2023-11-18 | 2025-12-18 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of AK3280 Cream on Hypertrophic Scar AK3280 Cream, Placebo cream - Hypertrophic Scar | Phase 1 / Phase 2 | Completed | Shanghai Ark Biopharmaceutical Co., Ltd. | 30 | 2022-07-08 | 2026-06-22 |
| A Study to Evaluate Topically Applied SXR1096 Cream in Patients With Netherton Syndrome SXR1096 cream, Placebo cream - Netherton Syndrome | Phase 1 / Phase 2 | Completed | Sixera Pharma | 9 | 2021-12-07 | 2025-12-16 |
| Treatment of Chronic Itch in Atopic Dermatitis With Topical Naltrexone Naltrexone, Placebo Cream - Atopic Dermatitis, Pruritus | Phase 2 | Withdrawn | University of Minnesota | 2020-10-01 | 2021-04-20 | |
| Phenytoin Cream for the Treatment of Neuropathic Pain phenytoin cream, Placebo cream - Chronic Idiopathic Axonal Polyneuropathy | Phase 2 / Phase 3 | Completed | David J. Kopsky | 81 | 2020-09-17 | 2023-06-28 |
| Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline, Placebo cream - Vestibulodynia, Temporomandibular Disorder | Phase 2 | Completed | Duke University | 209 | 2019-11-04 | 2026-03-19 |
| Effect of Topical CBD Cream for Degenerative Hallux Disorders magnesium-cannabidiolic acid cream, Placebo cream - Hallux Valgus, Hallux Rigidus | Phase 2 / Phase 3 | Terminated | Rush University Medical Center | 11 | 2019-10-20 | 2024-10-15 |
| A Phase IIb/III Study of Prof-001 for the Treatment of Patients With Recurrent Vulvovaginal Candidiasis (RVVC) Prof-001, Fluconazole 150 mg, Placebo cream - Recurrent Vulvovaginal Candidiasis | Phase 2 / Phase 3 | Unknown | ProFem GmbH | 432 | 2019-10-01 | 2022-09-22 |
| Topical Sm29 in Combination With Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis. Sm29 Protein, Schistosoma Mansoni, Pentavalent antimony (Sbv) - Cutaneous Leishmaniasis, American | Phase 1 / Phase 2 | Completed | Hospital Universitário Professor Edgard Santos | 20 | 2019-01-17 | 2023-08-21 |
| Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil Arm Clarithromycin (Not used as of 4/2020), Placebo (Not used as of 4/2020), Transdermal flumazenil (Added 4/2020) - Parkinson Disease | Phase 1 / Phase 2 | Completed | Nicolaas Bohnen, MD, PhD | 34 | 2018-01-29 | 2023-01-10 |
| Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD Cannabis Cream, Placebo Cream - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Completed | Medical University of Silesia | 20 | 2018-01-01 | 2019-06-21 |
| Study of Icotinib Hydrochloride Cream in Patients With Mild to Moderate Psoriasis Icotinib hydrochloride cream, Placebo cream - Mild to Moderate Psoriasis | Phase 2 | Terminated | Betta Pharmaceuticals Co., Ltd. | 136 | 2017-11-29 | 2018-11-14 |
| Safety and Efficacy Study of AM001 Cream in the Treatment of Actinic Keratosis AM001 Cream, 7.5%, Vehicle Cream - Actinic Keratosis | Phase 2 | Completed | AmDerma | 30 | 2017-06-06 | 2019-04-30 |
| Study of Testosterone and Athlete Response Testosterone cream 1% (Andro-Feme® ), Placebo cream - Athletic Performance, Testosterone | Phase 2 | Completed | Karolinska University Hospital | 48 | 2017-05-26 | 2022-10-12 |
| Safety and Efficacy Study Comparing AM001 Cream, 7.5% to Vehicle Cream in the Treatment of Plaque Psoriasis AM001 Cream, 7.5%, Vehicle Cream - Plaque Psoriasis | Phase 2 | Completed | AmDerma | 74 | 2016-12-01 | 2018-10-03 |
| A Trial of a Botanical Drug Containing East Indian Sandalwood Oil (EISO) for the Treatment of Molluscum Contagiosum 10% East Indian sandalwood oil cream, Placebo Cream - Molluscum Contagiosum | Phase 2 | Terminated | ViroXis Corporation | 27 | 2016-02-01 | 2019-04-16 |
| Lidocaine-prilocaine Cream on IUD Insertion Pain lidocaine-Prilocaine cream, placebo cream - IUD Pain | Phase 2 | Completed | Assiut University | 120 | 2016-01-01 | 2016-08-09 |
| A Study With Ruxolitinib Phosphate Cream Applied Topically to Subjects With Alopecia Areata (AA) Placebo Cream, Ruxolitinib Phosphate Cream - Alopecia Areata | Phase 2 | Terminated | Incyte Corporation | 90 | 2015-11-18 | 2020-12-16 |
Showing 20 of 34. Sign in to see all of them.
Psoriasis (4) · Keratosis, Actinic (3) · Dermatitis (2) · Leishmaniasis, Cutaneous (2) · Neuralgia (2) · Osteoarthritis (2) · Temporomandibular Joint Disorders (2) · Alopecia (1) · Alopecia Areata (1) · Alopecia universalis (1) · Back Pain (1) · Candidiasis, Vulvovaginal (1) · Chronic Pain (1) · Cicatrix, Hypertrophic (1) · Cystitis, Interstitial (1)
Incyte Corporation (3) · AmDerma (2) · AstraZeneca (2) · Assiut University (1) · Betta Pharmaceuticals Co., Ltd. (1) · David J. Kopsky (1) · Duke University (1) · EpiCept Corporation (1) · Fundacion Nacional de Dermatologia (1) · Graceway Pharmaceuticals, LLC (1) · Hospital Universitário Professor Edgard Santos (1) · Karolinska University Hospital (1) · Loyola University (1) · Mahidol University (1) · Medical University of Silesia (1)
United States (13) · Germany (3) · Austria (2) · Brazil (2) · China (2) · Kenya (2) · Poland (2) · Sweden (2) · Bolivia (1) · Dominican Republic (1) · Egypt (1) · France (1) · India (1) · Israel (1) · Netherlands (1)
Andrea Nackley, PhD (1) · Chemtai Mungo, MD, MPH (1) · Chuthamanee Suthisisang, Ph.D. (1) · Chuthamanee Suthisisant, Ph.D (1) · Cynthia Brincat, MD (1) · Denniz Zolnoun, MD MPH (1) · Eisenberg Elon, MD (1) · Eric Fossel, PhD (1) · Ernesto Rojas, MD (1) · Herbert Kiss, Prof. (1) · Jacqueline Rohl, MD (1) · Jaime Soto, MD (1)
PMID 20438389, PMID 22281165, PMID 23390069, PMID 28594757, PMID 28619556, PMID 31615775, PMID 33274381, PMID 35498440, PMID 36269028, PMID 36273216, PMID 39147194, PMID 41845293, PMID 42857927
R01HD096331 (1), R01NS099535 (1), R37CA306827 (1)