19 completed, 3 terminated, 3 unknown, 1 recruiting. 27 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 27 | Completed 19, Terminated 3, Unknown 3, Recruiting 1, Withdrawn 1 |
| Phase 2 | 5 | Completed 2, Unknown 2, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III) Total coumarin (TC) cream, Vehicle cream - Psoriasis Vulgaris, Topical Administration | Phase 3 | Recruiting | Psoriasis Research Institute of Guangzhou | 300 | 2026-02-01 | 2026-02-23 |
| Adjuvant Anal Imiquimod Therapy in Anal HPV-lesions: AdAM-trial Imiquimod 5% cream, Placebo cream, Fulguration - Anogenital Human Papillomavirus Infection, Condyloma Anal | Phase 3 | Unknown | Medical University Innsbruck | 200 | 2021-11-15 | 2020-09-23 |
| Lidocaine-Prilocaine Cream in Conjunction With Paracervical Block for Pain With Abortion Lidocaine-Prilocaine Cream, Placebo Cream, 1% Lidocaine Paracervical Block - Pain | Phase 3 | Withdrawn | Stanford University | 2020-12-01 | 2018-05-16 | |
| Phenytoin Cream for the Treatment of Neuropathic Pain phenytoin cream, Placebo cream - Chronic Idiopathic Axonal Polyneuropathy | Phase 2 / Phase 3 | Completed | David J. Kopsky | 81 | 2020-09-17 | 2023-06-28 |
| Effect of Topical CBD Cream for Degenerative Hallux Disorders magnesium-cannabidiolic acid cream, Placebo cream - Hallux Valgus, Hallux Rigidus | Phase 2 / Phase 3 | Terminated | Rush University Medical Center | 11 | 2019-10-20 | 2024-10-15 |
| A Phase IIb/III Study of Prof-001 for the Treatment of Patients With Recurrent Vulvovaginal Candidiasis (RVVC) Prof-001, Fluconazole 150 mg, Placebo cream - Recurrent Vulvovaginal Candidiasis | Phase 2 / Phase 3 | Unknown | ProFem GmbH | 432 | 2019-10-01 | 2022-09-22 |
| Myorelaxant Effect of Cannabis Cream Topical Skin Application in Patients With TMD Cannabis Cream, Placebo Cream - Temporomandibular Disorder, Myofascial Pain | Phase 2 / Phase 3 | Completed | Medical University of Silesia | 20 | 2018-01-01 | 2019-06-21 |
| 8-Week Atopic Dermatitis (AD) Treatment Study Investigational OTC Cream, 0.05% Desonide, Placebo Cream - Atopic Dermatitis Eczema | Phase 3 | Completed | Procter and Gamble | 65 | 2017-11-27 | 2020-12-17 |
| Comparative Safety and Efficacy of Two Treatments in the Treatment of Vulvar and Vaginal Atrophy estrace cream (Perrigo), estrace cream (Reference), Placebo cream - Atrophy | Phase 3 | Completed | Padagis LLC | 695 | 2016-05-01 | 2021-11-02 |
| Bioequivalence Study of Pimecrolimus Cream, 1% and Elidel® Cream, 1% in Mild to Moderate Atopic Dermatitis Pimecrolimus Cream, 1%, Placebo Cream - Atopic Dermatitis | Phase 3 | Completed | Mylan Inc. | 654 | 2016-02-29 | 2022-03-07 |
| Efficacy and Safety of CD5789 (Trifarotene) 50μg/g Cream Versus Vehicle Cream in Acne Vulgaris CD5789 (trifarotene) 50μg/g cream, Placebo cream - Acne Vulgaris | Phase 3 | Completed | Galderma R&D | 1208 | 2015-11-30 | 2019-11-12 |
| Double-Blind Efficacy and Safety of CD5789 (Trifarotene) 50µg/g Cream Versus Vehicle Cream in Acne Vulgaris CD5789 (trifarotene) 50µg/g Cream, Placebo Cream - Acne Vulgaris | Phase 3 | Completed | Galderma R&D | 1212 | 2015-11-01 | 2019-11-12 |
| Study of SST-0225 Topical Ibuprofen Cream in the Treatment of Delayed Onset Muscle Soreness (DOMS) SST-0225, Placebo - Delayed Onset Muscle Soreness, DOMS | Phase 3 | Completed | Strategic Science & Technologies, LLC | 156 | 2015-11-01 | 2016-10-13 |
| Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex Labialis Acyclovir 5 percent (Perrigo), Acyclovir 5 percent (Reference), Placebo cream - Herpes Labialis | Phase 3 | Completed | Padagis LLC | 4076 | 2014-10-06 | 2021-10-22 |
| Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris Naftin 1% Cream, Placebo Cream - Tinea Cruris, Jock Itch | Phase 3 | Completed | Merz North America, Inc. | 65 | 2013-08-01 | 2015-04-15 |
| Efficacy and Safety of Topical Essential Oil Extracted From Zingiber Cassumunar Rokb in Osteoarthritis Cream from Zingiber cassumunar Roxb. extract, Placebo cream - Osteoarthritis | Phase 2 / Phase 3 | Unknown | Mahidol University | 100 | 2012-12-01 | 2013-02-18 |
| Efficacy and Safety Study With Diltiazem Hydrochloride Cream to Treat Anal Fissures VEN 307, Placebo - Chronic Anal Fissures | Phase 3 | Completed | Ventrus Biosciences, Inc | 434 | 2012-10-01 | 2014-01-23 |
| Safety and Efficacy of Econazole Nitrate Foam 1% and Foam Vehicle in Subjects With Tinea Pedis Econazole Nitrate Foam 1%, Vehicle Foam, Econazole Nitrate Cream 1% - Tinea Pedis, Athlete's Foot | Phase 3 | Completed | AmDerma | 336 | 2011-06-01 | 2012-09-28 |
| Efficacy of Topical Capsaicin Cream for Stable Angina Capsaicin, Placebo cream - Stable Angina | Phase 3 | Terminated | Neal Weintraub | 7 | 2010-10-01 | 2015-06-25 |
| Bioequivalence Study of Generic Fluorouracil 0.5% Cream and 0.5% Carac® and Placebo Brand Carac, Generic 0.5% 5-fluorouracil cream, Placebo cream - Actinic Keratoses | Phase 3 | Completed | Spear Pharmaceuticals | 377 | 2010-09-01 | 2014-10-20 |
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Condylomata Acuminata (3) · Keratosis, Actinic (3) · Acne Vulgaris (2) · Pain (2) · Skin Diseases (2) · Tinea Pedis (2) · Agnosia (1) · Angina, Stable (1) · Atrophy (1) · Candidiasis, Vulvovaginal (1) · Carcinoma, Basal Cell (1) · Dermatitis, Atopic (1) · Hallux Rigidus (1) · Hallux Valgus (1) · Herpes Labialis (1)
Graceway Pharmaceuticals, LLC (4) · Galderma R&D (3) · Padagis LLC (2) · AmDerma (1) · Bayer (1) · David J. Kopsky (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Mahidol University (1) · Medical University Innsbruck (1) · Medical University of Silesia (1) · Merz North America, Inc. (1) · Mylan Inc. (1) · Neal Weintraub (1) · ProFem GmbH (1) · Procter and Gamble (1)
United States (18) · Poland (5) · Austria (2) · Canada (2) · Czechia (2) · Dominican Republic (2) · Germany (2) · Honduras (2) · Hungary (2) · Belize (1) · Netherlands (1) · Puerto Rico (1) · Romania (1) · Russia (1) · Slovakia (1)
Jason Wu, MD (2) · Amanda Salisbury, BSN (1) · Chuthamanee Suthisisang, Ph.D. (1) · Chuthamanee Suthisisant, Ph.D (1) · Daniel Piacquadio, MD (1) · David Seiden, MD (1) · Faisal M Khan, MD (1) · Herbert Kiss, Prof. (1) · Jerry Tan, MD (1) · Jiang Yang, MSc, PhD (1) · Kayce Morton, DO (1)
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