8 completed, 1 recruiting, 1 terminated, 1 unknown. 12 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 12 | Completed 8, Recruiting 1, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 1 | Completed 1 |
Follow Pilocarpine: new trials by email Literature Review of Pilocarpine trials Research Report on Pilocarpine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Xerostomia in Patients With a Life-limiting Condition or Frailty Pilocarpine, Placebo - Xerostomia, Dry Mouth | Phase 3 | Unknown | Maastricht University Medical Center | 120 | 2023-01-01 | 2022-08-18 |
| Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia Phentolamine Opthalmic Solution 0.75%, Placebo, Low dose pilocarpine - Presbyopia | Phase 3 | Completed | Opus Genetics, Inc | 333 | 2022-12-22 | 2026-10-30 |
| A Study to Assess Safety and Efficacy in Participants Age 40 to 55 With Presbyopia (Old Eye) Who Receive AGN-190584 in Both Eyes Twice Daily Pilocarpine HCl, Vehicle - Presbyopia | Phase 3 | Completed | Allergan | 230 | 2021-09-02 | 2023-03-21 |
| A Study to Assess the Impact and Adverse Events of Topical Eyedrops of AGN-190584 on Night-driving Performance in Participants, 40 to 55 Years of Age AGN-190584, Vehicle - Presbyopia | Phase 3 | Completed | AbbVie | 43 | 2021-05-14 | 2024-10-10 |
| Pilocarpine After Combined Cataract/Trabectome Surgery Pilocarpine, Ofloxacin, Prednisolone - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Withdrawn | Montefiore Medical Center | 2019-06-05 | 2022-04-07 | |
| Pilocarpine Use After Kahook Goniotomy Pilocarpine, Prednisolone, Ofloxacin - Glaucoma | Phase 3 | Recruiting | Montefiore Medical Center | 142 | 2019-05-01 | 2025-11-10 |
| Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer Pilocarpine, ALTENS - Head and Neck Cancer, Xerostomia | Phase 2 / Phase 3 | Completed | Radiation Therapy Oncology Group | 196 | 2008-09-01 | 2019-11-19 |
| Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer pilocarpine hydrochloride, placebo - Breast Cancer, Vaginal Dryness | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 201 | 2006-12-01 | 2016-08-12 |
| Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome Pilocarpine Hydrochloride, Placebo - Dry Eye | Phase 3 | Completed | Federal University of São Paulo | 32 | 2005-03-01 | 2020-07-14 |
| Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients Submandibular gland Transfer, Salagen - Cancer, Head and Neck Cancer | Phase 3 | Completed | Alberta Health services | 220 | 2002-04-01 | 2011-04-18 |
| Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids pilocarpine hydrochloride, Placebo - Oral Complications, Quality of Life | Phase 3 | Terminated | NCIC Clinical Trials Group | 4 | 1998-05-22 | 2020-04-03 |
| Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer pilocarpine hydrochloride, Placebo - Head and Neck Cancer, Oral Complications | Phase 3 | Completed | Radiation Therapy Oncology Group | 249 | 1998-03-01 | 2015-11-17 |
Head and Neck Neoplasms (3) · Presbyopia (3) · Xerostomia (3) · Breast Neoplasms (1) · Cataract (1) · Dry Eye Syndromes (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Hypopharyngeal Neoplasms (1) · Laryngeal Neoplasms (1) · Lymphoid Interstitial Pneumonia (1) · Mouth Neoplasms (1) · Nasopharyngeal Neoplasms (1) · Neoplasms (1) · Ocular Hypertension (1)
Montefiore Medical Center (2) · Radiation Therapy Oncology Group (2) · AbbVie (1) · Alberta Health services (1) · Allergan (1) · Alliance for Clinical Trials in Oncology (1) · Federal University of São Paulo (1) · Maastricht University Medical Center (1) · NCIC Clinical Trials Group (1) · Opus Genetics, Inc (1)
United States (7) · Canada (4) · Australia (1) · Brazil (1)
Charles L. Loprinzi, MD (1) · David Warr, MD (1) · Francis G. LeVeque, DDS (1) · Naresh Jha, MBBS (1) · Raimond K. W. Wong, MD (1) · Sergio Felberg, MD (1)
PMID 12788192, PMID 16724649, PMID 17043506, PMID 21702402, PMID 22252927, PMID 26065354, PMID 27479825, PMID 29432648, PMID 37612654, PMID 38044272