16 completed, 3 not yet recruiting, 3 unknown, 3 withdrawn. 10 Phase 4, 8 Not applicable, 5 Phase 3, 3 Phase 2, 1 Phase 1.
Follow Opioids: new trials by email Literature Review of Opioids trials Research Report on Opioids
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Cannabis Vs Opioids Pain Management Objective Testing Comparisons Monochromatic Infrared Photo Energy (MIRE), Transcutaneous Electrical Nerve Stimulation, Opioids - Chronic Pain, Circulatory Disorders | Not applicable | Not yet recruiting | American Association of Sensory Electrodiagnostic Medicine | 1000 | 2026-06-03 | 2025-12-29 |
| Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial Intrathecal morphine with bupivacaine, Hyperbaric Bupivicaine - Postoperative Pain, Cesarean Delivery | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 92 | 2025-10-15 | 2025-07-30 |
| Opioid Sparing Effect of an ISP Nerve Block on Post-Op Pain Control in Posterior Cervical Spine Surgery Inter-semispinalis Plane Block, Opioids - Pain, Postoperative | Not applicable | Recruiting | Stony Brook University | 60 | 2025-02-21 | 2026-04-29 |
| No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair Opioids, No opioids - Postoperative Pain, Inguinal Hernia | Phase 4 | Active not recruiting | Clayton Petro | 904 | 2023-07-10 | 2026-03-06 |
| Comparison of VER-01 to Opioids in Patients With Chronic Non-specific Low Back Pain VER-01, Opioid therapy - Chronic Non-specific Low Back Pain | Phase 3 | Completed | Vertanical GmbH | 384 | 2023-06-08 | 2024-11-25 |
| Dexmedetomine as Adjuvant for Spinal Anesthesia in Elective Cesarian Sections : a Pilot Study Dexmedetomidine 0.004 MG/ML [Precedex], Opioids - Analgesia, Analgesics, Opioid | Phase 3 | Completed | St. Justine's Hospital | 42 | 2022-03-15 | 2023-05-09 |
| Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery Toradol, Morphine, Orphenadrine - Pain Management, Posterior Spinal Fusion | Phase 4 | Completed | University of Puerto Rico | 100 | 2021-04-05 | 2022-06-10 |
| Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids - Opioid Use, Opioid Dependence | Phase 2 | Active not recruiting | Northwestern University | 60 | 2021-01-01 | 2024-11-27 |
| Opioid Therapy vs Multimodal Analgesia in Head and Neck Cancer Opioids, PAiN - multimodal analgesia - Head and Neck Cancer, Radiation-Induced Mucositis | Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 49 | 2020-08-04 | 2024-02-28 |
| ICE-T Pain Regimen for Total Laparoscopic Hysterectomy Ketorolac, Opioids, Ice Packs - Opioid Substitution Treatment | Phase 4 | Completed | MetroHealth Medical Center | 66 | 2019-08-01 | 2025-01-24 |
| Radiofrequency Ablation: Treatment for Posterior Element Pain From Vertebral Compression Fractures Radiofrequency ablation of the medial branch nerves, Non-steroidal anti-inflammatory drugs, Bisphosphonates - Vertebral Compression Fracture, Facet Joint Pain | Phase 4 | Withdrawn | University of California, Davis | 2019-04-10 | 2025-07-16 | |
| Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care Opioids, Dexmedetomidine, Placebo - Analgesia, Sedation | Phase 3 | Terminated | Walid HABRE | 33 | 2018-11-14 | 2021-07-28 |
| Opioid-free Accelerated Recovery Total Knee Arthroplasty opioids - Arthropathy of Knee Joint | Completed | St. Elizabeth Medical Center, Utica, NY | 400 | 2018-10-01 | 2020-05-12 | |
| Erector Spinae Plane Block Versus Paravertebral Block Paravertebral block, Erector spinae plane block, General anesthetic - Breast Cancer, Pain, Postoperative | Not applicable | Completed | University of Alberta | 48 | 2018-05-29 | 2022-07-28 |
| MAST Trial: Multi-modal Analgesic Strategies in Trauma Acetaminophen IV/PO, Acetaminophen PO, Ketorolac - Nonspecific Pain Post Traumatic Injury | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 1561 | 2018-04-02 | 2021-06-18 |
| Opioid-Free Orthopaedic Surgery Opioids, Opioid-Free - Pain Management | Not applicable | Completed | OrthoCarolina Research Institute, Inc. | 511 | 2018-03-26 | 2025-03-20 |
| Signs and Symptoms of Opioid-associated Iatrogenic Withdrawal in Critically Ill Adults Opioids - Substance Withdrawal Syndrome | Completed | Marc M. Perreault | 29 | 2018-02-26 | 2025-01-01 | |
| Opioid Withdrawal Symptoms in Critically Ill Patients Opioids - Substance Withdrawal Syndrome, Critical Illness | Completed | Mahidol University | 55 | 2018-01-01 | 2018-10-09 | |
| The Effect of the Transversus Abdominis Plane Block to Postoperative Analgesia for Cesarean Section TAP block, Morphine, Ropivacaine - Obstetric Pain | Not applicable | Completed | Gia Dinh People Hospital | 60 | 2017-07-10 | 2018-08-16 |
Showing 20 of 30. Sign in to see all of them.
Pain (8) · Agnosia (6) · Pain, Postoperative (5) · Chronic Pain (2) · Rib Fractures (2) · Substance Withdrawal Syndrome (2) · Wounds and Injuries (2) · Back Injuries (1) · Back Pain (1) · Bites and Stings (1) · Breast Neoplasms (1) · Cancer Pain (1) · Critical Illness (1) · Dyspnea (1) · Emergence Delirium (1)
Mahidol University (2) · Sahlgrenska University Hospital (2) · American Association of Sensory Electrodiagnostic Medicine (1) · Clayton Petro (1) · Gia Dinh People Hospital (1) · Johns Hopkins University (1) · Konya City Hospital (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Marc M. Perreault (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · MetroHealth Medical Center (1) · Montefiore Medical Center (1) · Northwestern University (1) · OrthoCarolina Research Institute, Inc. (1) · Soroka University Medical Center (1)
United States (11) · Canada (6) · Sweden (2) · Thailand (2) · Colombia (1) · France (1) · Germany (1) · Puerto Rico (1) · Switzerland (1) · Turkey (Türkiye) (1) · Vietnam (1)
Eva-Corina Caragounis, MD (2) · Hans Granhed, MD PhD (2) · Adriana Cadavid, MD (1) · Andrea Nicol, MD (1) · Andrew B Wickline, MD (1) · Apkar V Apkarian, PhD (1) · Brook Davis (1) · Chad Pfefer, M.D. (1) · Christina Lamontagne (1) · Clayton C Petro, MD (1) · David Copenhaver, MD (1) · David Palma, MD (1) · Dennis Jensen, Ph. D. (1) · Eman Nada, MBBCH (1)
PMID 10776874, PMID 15714323, PMID 23406078, PMID 28866754, PMID 33485328, PMID 33486130, PMID 33740977, PMID 33966568, PMID 37170043, PMID 37192425, PMID 38152462, PMID 40054624, PMID 40375321, PMID 41028525, PMID 9559604
KL2TR000370 (1), UL1TR000371 (1)