10 completed, 5 unknown, 2 recruiting, 1 active not recruiting. 20 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 20 | Completed 10, Unknown 5, Recruiting 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
Follow Opioid: new trials by email Literature Review of Opioid trials Research Report on Opioid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Post Operative | Phase 4 | Recruiting | University of Michigan | 900 | 2025-01-10 | 2026-10-20 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery Opioid-sparing based anesthesia, Sevoflurane-based anesthesia - Anesthesia, Hypoventilation | Phase 4 | Unknown | Tanta University | 72 | 2023-08-10 | 2023-07-27 |
| No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair Opioids, No opioids - Postoperative Pain, Inguinal Hernia | Phase 4 | Active not recruiting | Clayton Petro | 904 | 2023-07-10 | 2026-03-06 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Postoperative | Phase 4 | Recruiting | University of Michigan | 900 | 2023-02-06 | 2026-08-28 |
| Opioid Free Management After Ureteroscopy Norco 5milligram-325milligram Tablet, Ibuprofen 400 MILLIGRAM in 1 TABLET ORAL TABLET, FILM COATED - Kidney Stone | Phase 4 | Completed | Wake Forest University Health Sciences | 22 | 2019-09-19 | 2021-03-11 |
| Dexmedetomidine Versus Fentanyl Plus Bupivacaine for Epidural Analgesia With General Anesthesia for Lumbar Disc Operations Bupivacaine, Fentanyl, Dexmedetomidine - Anesthesia | Phase 4 | Completed | Ain Shams University | 80 | 2018-02-12 | 2018-09-27 |
| Intraperitoneal Bupivacaine With Magnesium or Nalbuphine for Postoperative Pain Control in Laparoscopic Hysterectomy Bupivacaine 0.25%, Magnesium sulphate., nalbuphine - Anesthesia | Phase 4 | Completed | Ain Shams University | 80 | 2018-01-03 | 2019-07-16 |
| Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study Fentanyl infusion, Ultrasound guided TAP block, Dexmedetomidine - Anesthesia | Phase 4 | Unknown | Ain Shams University | 20 | 2017-12-07 | 2018-01-09 |
| Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery Bupivacaine, Hydromorphone, Fentanyl - Pain | Phase 4 | Terminated | University of Texas Southwestern Medical Center | 46 | 2017-05-08 | 2023-10-26 |
| The Assessment of POCD After TURBT Under Spinal Anesthesia benzodiazepines, opioid, spinal anesthesia - Bladder Tumor, Postoperative Cognitive Dysfunction | Phase 4 | Unknown | Medical University of Warsaw | 200 | 2017-01-01 | 2017-01-24 |
| Ketamine in Colorectal Surgery Placebo, Ketamine, Acetaminophen - Acute Pain, Pain, Postoperative | Phase 4 | Withdrawn | Medical College of Wisconsin | 2016-07-01 | 2017-10-26 | |
| Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain Bupivacaine, Opioid - Pain, Intractable, Breakthrough Pain | Phase 4 | Completed | University Hospitals Cleveland Medical Center | 17 | 2016-05-01 | 2022-03-24 |
| Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients Ketamine, Placebo, Intercostal Nerve Block - Wounds and Injuries, Rib Fractures | Phase 4 | Completed | Medical College of Wisconsin | 153 | 2015-09-01 | 2020-02-05 |
| Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Local analgesic, Nerve Block, Intravenous analgesic - Pain, Complications | Phase 4 | Unknown | Guangzhou General Hospital of Guangzhou Military Command | 45 | 2014-03-01 | 2015-03-12 |
| The Effect of Choice of Intraoperative Opioid on Postoperative Pain Methadone, Fentanyl - Pain, Postoperative, Chronic Pain | Phase 4 | Completed | Endeavor Health | 164 | 2010-09-01 | 2019-09-30 |
| 0.05 mg Versus 0.1 mg Spinal Morphine for Reducing Morphine Requirement After Vaginal Hysterectomy Morphine - Pain | Phase 4 | Unknown | Mahidol University | 72 | 2010-03-01 | 2011-09-07 |
| Ultrasound Guidance for Interscalene Brachial Plexus Block Ultrasound-guided continuous interscalene brachial plexus block, Continuous interscalene brachial plexus block using electrical nerve stimulation, Ropivacaine - Shoulder, Orthopedic Surgery | Phase 4 | Completed | University of Parma | 50 | 2008-05-01 | 2009-11-16 |
| Ultrasound-Guided Axillary or Infraclavicular Nerve Block for Upper Limb Surgery Midazolam, Ropivacaine, Fentanyl - Upper Extremity, Orthopedic Surgery | Phase 4 | Completed | University of Parma | 52 | 2008-05-01 | 2009-07-15 |
| Comparison of Pain Therapeutic Effects After Benign Mastectomy Saline, Opioid, NSAID - Pain, Postoperative, Mastectomy | Phase 4 | Completed | Nanjing Medical University | 2000 | 2007-02-01 | 2009-03-31 |
Pain, Postoperative (7) · Pain (4) · Agnosia (2) · Chronic Pain (2) · Wounds and Injuries (2) · Acute Pain (1) · Breakthrough Pain (1) · Breast Neoplasms (1) · Forearm Injuries (1) · Hernia, Inguinal (1) · Hypoventilation (1) · Kidney Calculi (1) · Nephrolithiasis (1) · Pain, Intractable (1) · Postoperative Cognitive Complications (1)
Ain Shams University (3) · Medical College of Wisconsin (2) · University of Michigan (2) · University of Parma (2) · Aga Khan University (1) · Clayton Petro (1) · Endeavor Health (1) · Guangzhou General Hospital of Guangzhou Military Command (1) · Mahidol University (1) · Medical University of Warsaw (1) · Nanjing Medical University (1) · Tanta University (1) · University Hospitals Cleveland Medical Center (1) · University of Texas Southwestern Medical Center (1) · Wake Forest University Health Sciences (1)
United States (9) · Egypt (4) · Canada (2) · China (2) · Italy (2) · Pakistan (1) · Poland (1) · Thailand (1)
Giorgio Danelli, MD (2) · Mark Bicket, MD, PhD (2) · Thomas W Carver, MD (2) · Carrie Y Peterson, MD (1) · Clayton C Petro, MD (1) · Dileep Kumar, MBBS, FCPS (1) · Enas Kandil, MD (1) · Glenn S. Murphy, MD (1) · Guido Fanelli, MD (1) · Jorge Gutierrez-Aceves, MD (1) · Sirilak Suksompong, MD (1) · XiaoFeng Shen, MD (1)
PMID 17464603, PMID 18622068, PMID 2024744, PMID 30376537, PMID 40187774, PMID 42208996