27 completed, 12 unknown, 6 terminated, 4 active not recruiting. 20 Phase 4, 13 Not applicable, 9 Phase 3, 4 Phase 1, 4 Phase 2.
Follow Opioid: new trials by email Literature Review of Opioid trials Research Report on Opioid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Opioid-free Anesthesia as an Alternative to General Anesthesia in Patients Undergoing Duodenopancreatic Surgery by Laparotomy. Opioid, OFA - Pain Management | Not applicable | Recruiting | Jagiellonian University | 200 | 2026-09-02 | 2026-09-04 |
| Measuring Acute Drug Demand in Humans II Blinded Study Medication - Condition 1, Blinded Study Medication - Condition 2, Blinded Study Medication - Condition 3 - Healthy Volunteers | Early Phase 1 | Withdrawn | Johns Hopkins University | 2025-11-15 | 2025-11-12 | |
| Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain Opioid, Opioid Placebo - Pain, Chronic | Phase 2 | Recruiting | Mayo Clinic | 200 | 2025-04-16 | 2026-01-08 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Post Operative | Phase 4 | Recruiting | University of Michigan | 900 | 2025-01-10 | 2026-10-20 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery. non Opioids, Opioid - Undergoing Open-Heart Surgery | Completed | Ankara City Hospital Bilkent | 98 | 2024-04-03 | 2025-05-06 | |
| Effect of Esketamine on Depressive Symptoms of Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy Esketamine hydrochloride, Opioid - Depressive Symptoms | Not applicable | Unknown | The Second Hospital of Anhui Medical University | 400 | 2024-01-01 | 2024-01-10 |
| Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery Opioid-sparing based anesthesia, Sevoflurane-based anesthesia - Anesthesia, Hypoventilation | Phase 4 | Unknown | Tanta University | 72 | 2023-08-10 | 2023-07-27 |
| Reinforcing Effects of Marijuana and Opioids Marijuana, Opioid - Marijuana Use, Opioid Use | Phase 1 | Completed | Shanna Babalonis, PhD | 8 | 2023-08-03 | 2026-04-15 |
| No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair Opioids, No opioids - Postoperative Pain, Inguinal Hernia | Phase 4 | Active not recruiting | Clayton Petro | 904 | 2023-07-10 | 2026-03-06 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Postoperative | Phase 4 | Recruiting | University of Michigan | 900 | 2023-02-06 | 2026-08-28 |
| Split Scripts for Pediatric Supracondylar Fracture Repairs Morphine - Pain, Postoperative | Not applicable | Completed | The Hospital for Sick Children | 175 | 2022-08-11 | 2023-11-21 |
| Different Postoperative Analgesics Use After Ureteroscopy Opioid, Non-Opioid Analgesic, Non-Opioid - Post Operative Pain, Ureteroscopy | Not applicable | Unknown | Pakistan Kidney and Liver Institute and Research Center | 176 | 2022-08-01 | 2022-08-19 |
| Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy Tramadol, Gabapentin, Hydrocodone-Acetaminophen - Radical Prostatectomies | Phase 2 / Phase 3 | Withdrawn | Wake Forest University Health Sciences | 2022-08-01 | 2022-09-06 | |
| Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid Ketorolac, Opioid - Acute Pancreatitis | Phase 2 | Terminated | Boston Children's Hospital | 23 | 2022-03-15 | 2026-01-08 |
| Use of Patient-Controlled Analgesia in Acute Pancreatitis Opioid - Acute Pancreatitis | Terminated | Beth Israel Deaconess Medical Center | 7 | 2022-02-22 | 2024-11-22 | |
| The Effect of PCA on PONV After Microvascular Decompression NSAID, Opioid - Postoperative Nausea and Vomiting | Not applicable | Unknown | Seoul National University Hospital | 94 | 2021-12-20 | 2023-04-13 |
| Erector Spinae Plane Block for Rib Fracture Analgesia in the Emergency Department Erector Spinae Plane Block, IV Analgesia - Rib Fracture Multiple | Not applicable | Unknown | University of Southern California | 40 | 2021-07-01 | 2021-05-19 |
| Orthostatic Intolerance and Hypotension After Administration of Morphine in Patients Prior to Hip or Knee Arthroplasty Morphine - Orthostatic Hypotension, Orthostatic Intolerance | Unknown | Copenhagen University Hospital, Hvidovre | 26 | 2021-04-01 | 2021-06-18 | |
| Metabolomic Profiling of Erector Spinae Plane Block* for Breast Cancer Surgery Morphine, Erector Spinae Block, Control - Breast Cancer | Completed | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 91 | 2021-02-01 | 2023-01-19 |
Showing 20 of 57. Sign in to see all of them.
Pain, Postoperative (12) · Agnosia (9) · Pain (9) · Chronic Pain (5) · Breakthrough Pain (3) · Breast Neoplasms (3) · Pancreatitis (2) · Postoperative Nausea and Vomiting (2) · Wounds and Injuries (2) · Acute Pain (1) · Cancer Pain (1) · Depression (1) · Endometrial Neoplasms (1) · Forearm Injuries (1) · Hernia, Inguinal (1)
Ain Shams University (4) · Seoul National University Hospital (3) · Federal University of São Paulo (2) · KK Women's and Children's Hospital (2) · Medical College of Wisconsin (2) · Piramal Critical Care, Ltd. (2) · University of Michigan (2) · University of Parma (2) · Wake Forest University Health Sciences (2) · Aga Khan University (1) · Akela Pharma, Inc. (1) · Ankara City Hospital Bilkent (1) · Beth Israel Deaconess Medical Center (1) · Boston Children's Hospital (1) · Chosun University Hospital (1)
United States (23) · Egypt (5) · Canada (4) · Poland (4) · South Korea (4) · Brazil (3) · China (2) · Italy (2) · Pakistan (2) · Singapore (2) · Spain (2) · Turkey (Türkiye) (2) · Denmark (1) · Hungary (1) · New Zealand (1)
Giorgio Danelli, MD (2) · Mark Bicket, MD, PhD (2) · Thomas W Carver, MD (2) · Amit Grover, MB BCh BAO (1) · Ana Abad-Torrent, M.D (1) · Ban L Sng, FANZCA (1) · Carrie Y Peterson, MD (1) · Chang-Hoon Koo (1) · Chun Kee Chung, MD, PhD (1) · Chun Kee Chung, Professor (1) · Clayton C Petro, MD (1) · Conor Mc Donnell (1) · Dileep Kumar, MBBS, FCPS (1) · Enas Kandil, MD (1) · Faris Murad, M.D. (1)
PMID 17464603, PMID 18622068, PMID 19411668, PMID 2024744, PMID 25901477, PMID 26497721, PMID 28922235, PMID 30202425, PMID 30252709, PMID 30376537, PMID 30424939, PMID 31045633, PMID 31298153, PMID 31387410, PMID 33209056, PMID 33845761, PMID 38335521, PMID 40187774, PMID 42208996
R01DA045700 (1)