13 completed, 6 recruiting, 2 terminated, 1 active not recruiting. 15 Not applicable, 2 Early Phase 1, 2 Phase 2, 2 Phase 3, 2 Phase 4.
Follow Nicotine replacement: new trials by email Literature Review of Nicotine replacement trials Research Report on Nicotine replacement
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide for Smoking Cessation in Patients With Diabetes Semaglutide, Nicotine replacement - Diabetes Mellitus, Type 2, Nicotine Addiction | Phase 3 | Recruiting | Ottawa Heart Institute Research Corporation | 100 | 2026-02-13 | 2026-09-08 |
| Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial Brainsway H4 deep Repetitive Transcranial Magnetic Stimulation (rTMS) coil, Nicotine replacement - Tobacco Use Disorder, Psychiatric Disorder | Phase 4 | Recruiting | Centre for Addiction and Mental Health | 40 | 2024-09-01 | 2025-12-11 |
| A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior Nicotine Replacement, Questionnaire Administration, Vaping - Cigarette Smoking-Related Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 1500 | 2024-04-10 | 2026-04-06 |
| Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Health Staff Music intervention, Nicotine replacement - Smoking Cessation | Not applicable | Unknown | Poitiers University Hospital | 50 | 2024-02-28 | 2024-03-01 |
| Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung Best Practice, Nicotine Replacement, Quality-of-Life Assessment - Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Withdrawn | Ohio State University Comprehensive Cancer Center | 2024-01-01 | 2024-04-12 | |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers Biospecimen Collection, Cognitive Assessment, Interview - Cigarette Smoking-Related Carcinoma | Not applicable | Completed | Ohio State University Comprehensive Cancer Center | 27 | 2023-06-26 | 2024-12-20 |
| Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students Music Intervention, Nicotine replacement - Smoking Cessation | Not applicable | Recruiting | Poitiers University Hospital | 120 | 2022-12-13 | 2025-12-29 |
| Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes Nicotine Replacement, Questionnaire Administration, Electronic Cigarette - Cigarette Smoking-Related Carcinoma | Not applicable | Completed | M.D. Anderson Cancer Center | 169 | 2022-06-02 | 2026-01-28 |
| Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer Nicotine Replacement - Lung Carcinoma | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 135 | 2022-03-07 | 2026-08-05 |
| Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use Nicotine Replacement, Bupropion Hydrochloride Controlled-release, Varenicline - Lung Non-Small Cell Carcinoma, Head and Neck Squamous Cell Carcinoma | Not applicable | Completed | Thomas Jefferson University | 19 | 2020-08-19 | 2025-09-09 |
| Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial Bupropion Hydrochloride Controlled-release, Nicotine Replacement, Questionnaire Administration - Cigarette Smoking-Related Carcinoma | Phase 4 | Recruiting | M.D. Anderson Cancer Center | 2010 | 2020-08-04 | 2026-10-07 |
| Episodic Future Thinking and Future Thinking Priming for Smoking Cessation Behavioral Intervention, Informational Intervention, Nicotine Replacement - Tobacco-Related Carcinoma | Not applicable | Terminated | Roswell Park Cancer Institute | 26 | 2020-01-01 | 2024-02-08 |
| Smoking Cessation in a Cohort HIV+ Rio de Janeiro, Brazil. Nicotine replacement - Smoking Cessation, Brachial Flow Mediated Dilatation | Completed | Instituto Fernandes Figueira | 115 | 2019-12-10 | 2023-05-24 | |
| Implementing a Virtual Tobacco Treatment for Cancer Patients in Community Oncology Practices Behavioral, Psychological or Informational Intervention, Nicotine Replacement, Quality-of-Life Assessment - Carcinoma In Situ, Current Smoker | Not applicable | Completed | ECOG-ACRIN Cancer Research Group | 306 | 2019-08-01 | 2025-03-18 |
| Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs Bronchoscopy with Bronchoalveolar Lavage, Cigarette, Electronic Cigarette - Cigarette Smoker, Current Every Day Smoker | Early Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 66 | 2018-09-17 | 2026-04-23 |
| Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers Cigarette, Nicotine Replacement, Questionnaire Administration - Cigarette Smoking-Related Carcinoma, Tobacco-Related Carcinoma | Not applicable | Completed | M.D. Anderson Cancer Center | 213 | 2017-10-26 | 2025-12-09 |
| Bupropion Hydrochloride or Patient's Choice for Smoking Cessation in Patients With Squamous Cell Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Bupropion Hydrochloride, Laboratory Biomarker Analysis, Nicotine Replacement - Current Smoker, Head and Neck Squamous Cell Carcinoma | Early Phase 1 | Terminated | Wake Forest University Health Sciences | 9 | 2016-01-01 | 2023-03-22 |
| Connect to Quit for Smoking Coordinated Care, Usual Care - Smoking, Smoking Cessation | Not applicable | Completed | University of Pittsburgh | 633 | 2011-03-01 | 2016-03-22 |
| Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer questionnaire administration, quality-of-life assessment, counseling intervention - Limited Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 1 | Completed | Wake Forest University Health Sciences | 6 | 2011-01-01 | 2018-08-01 |
Showing 20 of 24. Sign in to see all of them.
Smoking Cessation (9) · Tobacco Use Disorder (6) · Carcinoma, Non-Small-Cell Lung (3) · Squamous Cell Carcinoma of Head and Neck (3) · Lung Neoplasms (2) · Carcinoma in Situ (1) · Cardiovascular Diseases (1) · Cigarette Smoking (1) · Diabetes Mellitus, Type 2 (1) · Mental Disorders (1) · Nasopharyngeal Carcinoma (1) · Neoplasms (1) · Obesity (1) · Overweight (1) · Recurrence (1)
M.D. Anderson Cancer Center (4) · Ohio State University Comprehensive Cancer Center (4) · Poitiers University Hospital (2) · Wake Forest University Health Sciences (2) · Centre for Addiction and Mental Health (1) · ECOG-ACRIN Cancer Research Group (1) · Hospital do Coracao (1) · Instituto Fernandes Figueira (1) · Johns Hopkins University (1) · National Institute on Drug Abuse (NIDA) (1) · Ottawa Heart Institute Research Corporation (1) · Roswell Park Cancer Institute (1) · Thomas Jefferson University (1) · University of California, San Francisco (1) · University of Pittsburgh (1)
United States (17) · Brazil (2) · Canada (2) · France (2) · South Africa (1)
Jason Robinson (2) · Anne Joseph, MD (1) · Christine Sheffer (1) · Elyse Park (1) · Hilary A. Tindle, MD, MPH (1) · Jason Robinson, PHD (1) · Jonathan E Golub, PhD MPH (1) · Julianna Nemeth, PhD (1) · Kathryn Weaver (1) · Marney A White, PhD, MS (1) · Mercedes Porosnicu (1) · Neil Martison (1) · Paul Cinciripini (1) · Peter Shields, MD (1) · Silvia Ismael (1)
PMID 33605440, PMID 35841024, PMID 40543725, PMID 41051837, PMID 42441935
K07CA215546 (1), P30CA012197 (1), P50DA013333 (1), R01CA141596 (1), R01CA214427 (1), R01CA238478 (1), R01DA042526 (1), R01DA057327 (1), U01CA261626 (1), U01DA045530 (1), U01DA047875 (1)