45 completed, 16 unknown, 6 terminated, 4 recruiting. 29 Phase 2, 14 Not applicable, 14 Phase 4, 13 Phase 3, 9 Phase 1.
Follow N-acetyl cysteine: new trials by email Literature Review of N-acetyl cysteine trials Research Report on N-acetyl cysteine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome N-acetyl cysteine, Placebo - Cornelia de Lange Syndrome | Phase 2 | Not yet recruiting | Johns Hopkins University | 10 | 2026-11-01 | 2026-08-14 |
| The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients N-acetyl cysteine, Metfomin - Polycystic Ovary Syndrome | Phase 3 | Completed | Cairo University | 102 | 2025-03-01 | 2026-10-21 |
| Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease N-Acetyl cysteine, Dexamethasone Oral, N-Acetyl cysteine Placebo - Lung Cancer, Interstitial Lung Disease | Phase 2 | Recruiting | David Palma | 98 | 2025-01-07 | 2026-08-26 |
| Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair Ascorbic acid, N-acetyl cysteine, placebo - Rotator Cuff Tears | Phase 4 | Unknown | Mahidol University | 110 | 2024-05-01 | 2024-04-25 |
| Chlorhexidine Versus N-Asetil Sistein Irrigation in Mandibular Molar Teeth with Chronic Apical Periodontitis N-Acetyl Cysteine, Chlorhexidine - Chronic Apical Periodontitis | Not applicable | Completed | Cukurova University | 78 | 2024-02-15 | 2025-02-20 |
| Protective Effect of N-acetylcysteine on Oxaliplatin-Induced Neuropathy in Colorectal Cancer Placebo, N-Acetyl Cysteine, Modified FOLFOX-6 regimen - Colorectal Cancer | Not applicable | Completed | Tanta University | 46 | 2024-01-01 | 2026-02-10 |
| Clinical Effects of New Approach on Patients With Non-alcoholic Steatohepatitis Rosuvastatin 20mg - Non-alcoholic Steatohepatitis | Early Phase 1 | Completed | Beni-Suef University | 175 | 2023-12-17 | 2025-02-06 |
| Ameliorating Contrast Induced Nephropathy After Coronary Angiography Atorvastatin 80mg, N-acetyl cysteine, Normal Saline - Coronary Artery Disease, Nephropathy; Toxic, Drugs | Phase 4 | Completed | Ain Shams University | 120 | 2023-12-01 | 2024-07-11 |
| GWICTIC: NAC Mechanistic Study in Gulf War Veterans N-Acetyl Cysteine, Placebo - Gulf War Syndrome | Early Phase 1 | Recruiting | Nova Southeastern University | 170 | 2023-11-30 | 2025-07-08 |
| Evaluation of Using Dienogest and N-Acetyl Cysteine on the Volume of Uterine Leiomyoma Dienogest 2 MG, N-acetyl cysteine - Uterine Leiomyoma | Phase 2 / Phase 3 | Completed | Ain Shams University | 40 | 2023-09-01 | 2024-12-16 |
| A Pan-TB Regimen Targeting Host and Microbe Sutezolid, N-acetyl cysteine, Pretomanid - Tuberculosis | Phase 2 / Phase 3 | Active not recruiting | The Aurum Institute NPC | 352 | 2023-07-28 | 2025-05-28 |
| Effect of N-acetyl Cysteine and Zinc in Management of Head and Neck Cancer Radiotherapy Induced Oral Mucositis N-acetyl cysteine, Zinc sulfate, saline mouth wash - Radiation-Induced Mucositis | Phase 2 | Completed | Mansoura University | 50 | 2023-06-28 | 2024-12-31 |
| Intravenous N-acetylcysteine and Oseltamivir Versus Oseltamivir in Adults Hospitalized With Influenza and Pneumonia N-acetyl cysteine, 5% Dextrose - Influenza | Phase 3 | Recruiting | Chinese University of Hong Kong | 160 | 2023-05-08 | 2026-10-20 |
| A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder N-acetyl cysteine, Placebo - Alcohol Use Disorder (AUD) | Phase 4 | Recruiting | University of Sydney | 280 | 2023-02-16 | 2023-03-16 |
| Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp N-acetyl cysteine, Calcium hydroxide - Intracanal Medication, N-acetylcystine | Early Phase 1 | Unknown | Cairo University | 30 | 2023-02-01 | 2022-12-27 |
| the Safety and Efficacy of N-acetyl Cysteine in Children With Drug-Resistant Epilepsy N-acetyl cysteine, Placebo, NAc - Drug Resistant Epilepsy | Phase 2 | Completed | Tanta University | 90 | 2022-09-15 | 2025-07-01 |
| Defining N-Acetyl Cysteine as a Treatment for Inhibiting Prurogenic Stimuli N-acetyl cysteine, Placebo - Pruritus, Skin Disorder | Early Phase 1 | Completed | Wright State University | 20 | 2022-06-19 | 2024-03-06 |
| Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder N-Acetyl cysteine, Placebo - Bipolar Disorder, Bipolar I Disorder | Phase 2 | Completed | Medical University of South Carolina | 12 | 2022-05-13 | 2024-06-26 |
| The Efficacy of N-acetyl-cysteine in the Treatment of Burning Mouth Syndrome N-acetyl cysteine, placebo - Burning Mouth Syndrome | Not applicable | Completed | University of Zagreb | 80 | 2022-05-01 | 2025-05-14 |
| Impact of N-acetylcysteine Infusion and Intralipid Infusion on Myocardial Injury in Aluminum Phosphide Toxicity N-acetyl cysteine - Myocardial Injury | Not applicable | Unknown | Assiut University | 58 | 2022-05-01 | 2022-05-11 |
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Antonio Hardan, MD (2) · Jon E Grant, MD, JD (2) · Parvaneh Afsharian, PhD (2) · Ahmed R El-Adawy, Professor (1) · Amr Mahmoud, lecturer (1) · Amr Z Abdelhamid, PhD (1) · Andrew B. Newberg, MD (1) · Ashraf Moini, MD (1) · Asmaa Mohammed Hussein, Assis.Prof (1) · Cathie Spino, ScD (1) · Craig Rohan, MD (1)
PMID 34582562, PMID 10488881, PMID 10924859, PMID 14605526, PMID 16953900, PMID 18993042, PMID 19581567, PMID 21752095, PMID 22342106, PMID 23251869, PMID 24515621, PMID 25222041, PMID 25970116, PMID 27007062, PMID 29588126, PMID 30549489, PMID 31573637, PMID 32970845, PMID 33660691, PMID 33675156, PMID 33725178, PMID 34036177, PMID 34377857, PMID 34623633, PMID 35393384, PMID 36182028, PMID 36514019, PMID 36699521, PMID 36856701, PMID 36996759, PMID 37271412, PMID 37694125, PMID 39189858, PMID 39910268, PMID 40038825, PMID 40430469, PMID 40480879, PMID 40489761, PMID 40921646, PMID 41701447, PMID 41749341, PMID 8706483, PMID 8844239, PMID 9272682
R21AA026129 (1), R21DA043055 (1), R21DA044005 (1), U24HL145265 (1)