8 completed, 4 not yet recruiting, 4 recruiting, 1 active not recruiting. 7 Phase 1, 4 Phase 4, 3 Phase 2, 2 Not applicable, 2 Phase 3.
Follow Monotherapy: new trials by email Literature Review of Monotherapy trials Research Report on Monotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabis Gummy for the Improvement of Sleep and Quality of Life in Patients With Cancer, Pillow Trial Actigraphy, Best Practice, Biospecimen Collection - Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm | Phase 1 / Phase 2 | Not yet recruiting | Theodore Brasky PhD | 50 | 2027-01-15 | 2026-10-14 |
| BSB-2002 After Cyclophosphamide and Fludarabine for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy - Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia | Phase 1 | Not yet recruiting | City of Hope Medical Center | 19 | 2026-12-14 | 2026-05-13 |
| THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia Biospecimen Collection, Placebo Administration, Single Agent Therapy - Insomnia, Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | Mayo Clinic | 69 | 2026-10-01 | 2026-09-02 |
| Clinical Trial to Evaluate the Efficacy and Safety in Concomitant Administration of Macitentan and Dapagliflozin in Patients With Heart Failure With Mildly Reduced and Preserved Ejection Fraction (HFmrEF and HFpEF) and Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Combination therapy, Monotherapy - Combined Pre- and Post-capillary Pulmonary Hypertension, CpcPH | Phase 4 | Recruiting | Gachon University Gil Medical Center | 64 | 2025-11-24 | 2026-04-03 |
| Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease Biospecimen Collection, Dasatinib, Fisetin - Glioma | Early Phase 1 | Recruiting | Mayo Clinic | 30 | 2025-08-12 | 2026-10-01 |
| Immediate Fracture Risk After Antihypertensive Drug Initiation Monotherapy, Combination therapy - Hypertension, Fracture | Not yet recruiting | Ajou University School of Medicine | 10000000 | 2025-06-01 | 2025-05-28 | |
| Study to Assess the Safety, Tolerability, and Blood Concentration of PMC-309 PMC-309 monotherapy, PMC-309 Dose Escalation in Combination with Pembrolizumab(KEYTRUDA®), PMC-309 Dose Expansion - Advanced or Metastatic Solid Tumors | Phase 1 | Recruiting | PharmAbcine | 67 | 2024-01-03 | 2025-12-30 |
| Study to Assess Safety and Tolerability of PMC-403 in Subjects With Neovascular Age-related Macular Degeneration PMC-403 - Neovascular Age-related Macular Degeneration | Phase 1 | Completed | PharmAbcine | 17 | 2023-07-20 | 2025-12-30 |
| Platelet Sub-study of the Neomindset Trial Dual antiplatelet therapy: Acetylsalicylic acid + ticagrelor OR Acetylsalicylic acid + prasugrel, Monotherapy: Ticagrelor alone OR Prasugrel alone - Acute Coronary Syndrome | Phase 4 | Active not recruiting | Hospital Israelita Albert Einstein | 48 | 2023-02-06 | 2025-04-08 |
| HCW9218 in Select Advanced Solid Tumors HCW9218 - Solid Tumor | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 18 | 2022-04-01 | 2025-11-05 |
| Percutaneous Coronary Intervention Followed by Antiplatelet Monotherapy in the Setting of Acute Coronary Syndromes Antiplatelet Monotherapy - Acute Coronary Syndrome | Phase 3 | Completed | Hospital Israelita Albert Einstein | 3410 | 2020-10-15 | 2025-07-03 |
| A Trial of ZL-1201 in Subjects With Advanced Cancer ZL-1201 - Advanced Cancer | Phase 1 | Completed | Zai Lab (Shanghai) Co., Ltd. | 37 | 2020-05-11 | 2023-08-22 |
| VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma VMD-928 100 mg Tablet, VMD-928 Tablet and Pembrolizumab (200 mg) - Head and Neck Carcinoma, Adenoid Cystic Carcinoma | Phase 1 / Phase 2 | Recruiting | VM Oncology, LLC | 242 | 2018-06-08 | 2025-12-11 |
| Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery Dual therapy, Monotherapy, General anesthesia - Postoperative Nausea and Vomiting | Not applicable | Completed | Makassed General Hospital | 120 | 2018-02-15 | 2019-09-27 |
| Nicotine Receptor Density & Response to Nicotine Patch: Pt 2 Extended Treatment Combination Bupropion + NRTs, Extended Treatment, Home Visits & Calls - Smoking Cessation, Schizophrenia | Phase 4 | Completed | Brentwood Biomedical Research Institute | 42 | 2014-01-01 | 2019-07-30 |
| Single Versus Combined Antibiotic Therapy for Bacterial Peritonitis in CAPD Patients ceftazidime+ciprofloxacin, ceftazidime monotherapy, cefazolin+gentamicin - Peritonitis | Not applicable | Completed | Chulalongkorn University | 300 | 2012-12-01 | 2024-02-21 |
| Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma Dabrafenib, Vemurafenib, Trametinib - Melanoma | Phase 3 | Completed | Novartis Pharmaceuticals | 704 | 2012-06-04 | 2021-02-24 |
| Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty Rifampin-combination therapy, Monotherapy - Prosthesis-related Infections, Staphylococcal Infections | Phase 4 | Unknown | Oslo University Hospital | 100 | 2006-04-01 | 2013-06-27 |
Acute Coronary Syndrome (2) · Carcinoma, Adenoid Cystic (1) · Carcinoma, Non-Small-Cell Lung (1) · Esophageal Neoplasms (1) · Fractures, Bone (1) · Glioma (1) · Head and Neck Neoplasms (1) · Hematologic Neoplasms (1) · Hypertension (1) · Laryngeal Diseases (1) · Leukemia, Myeloid, Acute (1) · Lung Neoplasms (1) · Melanoma (1) · Mesothelioma (1) · Neoplasm Metastasis (1)
Hospital Israelita Albert Einstein (2) · Mayo Clinic (2) · PharmAbcine (2) · Ajou University School of Medicine (1) · Brentwood Biomedical Research Institute (1) · Chulalongkorn University (1) · City of Hope Medical Center (1) · Gachon University Gil Medical Center (1) · Makassed General Hospital (1) · Masonic Cancer Center, University of Minnesota (1) · Novartis Pharmaceuticals (1) · Oslo University Hospital (1) · Theodore Brasky PhD (1) · VM Oncology, LLC (1) · Zai Lab (Shanghai) Co., Ltd. (1)
United States (9) · Brazil (3) · South Korea (3) · Australia (2) · Norway (2) · Argentina (1) · Austria (1) · Belgium (1) · Canada (1) · China (1) · Czechia (1) · Denmark (1) · Finland (1) · France (1) · Germany (1)
Andrea Tazbirkova, Dr (1) · Finnur Snorrason, M.D, Ph.D (1) · Melissa Geller, MD (1) · Nalinee Saiprasertkit, MD. (1) · Pedro A Lemos, MD (1) · Pedro A Lemos, MD, PhD (1) · Rae Woong Park, M.D., Ph.D. (1) · Ryotaro Nakamura (1) · SeJoon Woo (1) · Stacy D. D'Andre, MD (1) · Terence C. Burns, MD, PhD (1) · Theodore Brasky, PhD (1)
PMID 25399551, PMID 26433819, PMID 27864013, PMID 31166680, PMID 32859235, PMID 34225229, PMID 40888723, PMID 41384891, PMID 42200630
P30CA033572 (1)