36 completed. 36 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 36 | Completed 36 |
| Phase 2 | 4 | Completed 4 |
Follow Modafinil: new trials by email Literature Review of Modafinil trials Research Report on Modafinil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis Amantadine, Modafinil, Methylphenidate - Fatigue in Multiple Sclerosis | Phase 3 | Completed | Johns Hopkins University | 141 | 2017-10-04 | 2020-10-20 |
| Armodafinil in Reducing Cancer-Related Fatigue in Patients With High Grade Glioma armodafinil 150 mg, Placebo, armodafinil 250 mg - Fatigue | Phase 3 | Completed | Alliance for Clinical Trials in Oncology | 328 | 2013-06-21 | 2025-01-27 |
| Armodafinil (Nuvigil), Postoperative Recovery of OSA (Obstructive Sleep Apnea) and Obese Patients Nuvigil, Placebo - Obesity, Premature Recovery From Anesthesia | Phase 3 | Completed | University of Texas Southwestern Medical Center | 67 | 2011-08-01 | 2018-12-04 |
| Cross-over Study of Armodafinil Treatment of Daytime Sleepiness Associated With Treated Nocturia Armodafinil, Placebo - Nocturia, Daytime Sleepiness | Phase 2 / Phase 3 | Completed | Duke University | 81 | 2011-05-01 | 2017-03-24 |
| Study to Evaluate the Efficacy and Safety of Armodafinil Treatment (150 mg/Day) as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Armodafinil, Placebo - Depression | Phase 3 | Completed | Cephalon | 399 | 2011-03-01 | 2016-05-26 |
| Effects of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy. BF2.649, Vigil, palcebo - Treatment of Excessive Daytime Sleepiness in Narcolepsy | Phase 3 | Completed | Bioprojet | 180 | 2010-11-01 | 2017-01-31 |
| Modafinil in Cancer Related Fatigue Modafinil, Pyridoxine - Cancer Related Fatigue, Quality of Life | Phase 3 | Completed | Indira Gandhi Medical College, Shimla | 217 | 2010-08-01 | 2012-03-23 |
| A Study of the Effectiveness of Armodafinil to Treat Cancer-Related Fatigue in Patients With Multiple Myeloma armodafinil, Placebo - Fatigue, Multiple Myeloma | Phase 3 | Completed | Oncotherapeutics | 50 | 2010-06-01 | 2014-11-06 |
| Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Armodafinil, Placebo - Depression | Phase 3 | Completed | Cephalon | 492 | 2010-03-01 | 2016-04-27 |
| A Study to Evaluate the Efficacy and Safety of Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder Armodafinil, Placebo - Depression | Phase 3 | Completed | Cephalon | 433 | 2010-01-01 | 2016-04-27 |
| Armodafinil in Binge Eating Disorder (BED) Armodafinil, Matching placebo - Binge Eating Disorder, Overweight | Phase 3 | Completed | Lindner Center of HOPE | 60 | 2009-11-01 | 2015-05-14 |
| Efficacy and Safety Study of BF2.649 and BF2.649 Add on Modafinil on Cataplexy in Patients With Narcolespy BF2.649, BF2.649 add on Modafinil - Narcolepsy, Cataplexy | Phase 3 | Completed | Bioprojet | 14 | 2009-10-01 | 2013-02-11 |
| Impact of Armodafinil on Neurocognition and Cognitive Fatigue in Multiple Sclerosis (MS) armodafinil - Multiple Sclerosis | Phase 2 / Phase 3 | Completed | University of Missouri, Kansas City | 33 | 2009-09-01 | 2013-10-14 |
| Study With Modafinil in Patients Treated With Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer (MOTIF) DOCETAXEL(XRP6976) + MODAFINIL, Modafinil, Placebo of Modafinil - Prostatic Neoplasms, Breast Cancer | Phase 3 | Completed | Sanofi | 84 | 2009-06-01 | 2012-09-26 |
| Efficacy and Safety Study of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy BF2.649, Modafinil, Placebo - Narcolepsy, Excessive Daytime Sleepiness | Phase 3 | Completed | Bioprojet | 110 | 2009-05-01 | 2012-06-11 |
| Brain Imaging Study of the Effects of Modafinil in Cocaine Addiction Modafinil and PET (brain imaging), placebo - Cocaine Addiction, Cocaine Dependence | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 29 | 2009-04-01 | 2013-04-11 |
| Study of the Effect of Armodafinil Treatment in Healthy Subjects With Excessive Sleepiness Associated With Jet Lag Disorder armodafinil, placebo - Excessive Sleepiness | Phase 3 | Completed | Cephalon | 427 | 2008-09-01 | 2013-07-19 |
| Use of Armodafinil for Fatigue in Sarcoidosis Armodafinil, Placebo - Sarcoidosis, Fatigue | Phase 2 / Phase 3 | Completed | University of Cincinnati | 20 | 2007-10-01 | 2015-05-27 |
| Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment Modafinil - Attention Deficit Hyperactivity Disorder | Phase 3 | Completed | Cephalon | 120 | 2006-06-01 | 2014-05-09 |
| Study to Assess Patient Reported Outcomes With Armodafinil Treatment for Excessive Sleepiness in Adults With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome Armodafinil - Excessive Daytime Sleepiness, Narcolepsy | Phase 3 | Completed | Cephalon | 247 | 2005-10-01 | 2013-07-19 |
Showing 20 of 36. Sign in to see all of them.
Disorders of Excessive Somnolence (14) · Narcolepsy (10) · Sleep Apnea, Obstructive (7) · Cataplexy (5) · Fatigue (4) · Attention Deficit Disorder with Hyperactivity (3) · Depression (3) · Chronobiology Disorders (2) · Obesity (2) · Sleep Apnea Syndromes (2) · Sleep Disorders, Circadian Rhythm (2) · Sleep Wake Disorders (2) · Alzheimer Disease (1) · Behavior, Addictive (1) · Binge-Eating Disorder (1)
Cephalon (18) · Bioprojet (3) · Duke University (2) · Alliance for Clinical Trials in Oncology (1) · Assistance Publique - Hôpitaux de Paris (1) · Brown University (1) · Gary Morrow (1) · Indira Gandhi Medical College, Shimla (1) · Jazz Pharmaceuticals (1) · Johns Hopkins University (1) · Lindner Center of HOPE (1) · Oncotherapeutics (1) · Sanofi (1) · University of Cincinnati (1) · University of Missouri, Kansas City (1)
United States (24) · Canada (4) · France (4) · Switzerland (3) · Argentina (2) · Australia (2) · Bulgaria (2) · Germany (2) · Poland (2) · South Africa (2) · Ukraine (2) · Brazil (1) · Croatia (1) · Finland (1) · Hungary (1)
Claudio Bassetti (2) · Alyx B. Porter Umphrey, MD (1) · Andrew Krystal, MD (1) · Bardia Nourbakhsh, MD (1) · Enas Kandil, MD (1) · Gary R. Morrow, PhD, MS (1) · Gwendolyn Neibler, DO (1) · James Berenson, MD (1) · Jared M Bruce, PhD (1) · Jonathan Davidson, M.D. (1) · Laura L Frakey, Ph.D. (1) · Michel Reynaud, PhD (1) · Robert P Baughman, MD (1)
PMID 20564068, PMID 16895262, PMID 19270033, PMID 19318599, PMID 19416039, PMID 19880686, PMID 20530317, PMID 21046171, PMID 21206549, PMID 22687392, PMID 24107292, PMID 24337761, PMID 25099397, PMID 25933099, PMID 26011779, PMID 26330288, PMID 29113955, PMID 29221779, PMID 32356515, PMID 33242419, PMID 34822113, PMID 34882169, PMID 34935103
2008 (2), 2009 (2), F32MH075583 (1), U10CA037404 (1), U10CA037420 (1), U10CA037447 (1), UG1CA189823 (1)