10 completed, 7 unknown, 2 recruiting, 1 active not recruiting. 16 Not applicable, 3 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 8, Unknown 6, Active not recruiting 1, Recruiting 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow menaquinone 7: new trials by email Literature Review of menaquinone 7 trials Research Report on menaquinone 7
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin K2 Supplementation in Adult Episodic Migraine Vitamin K2 or menaquinone-7, Placebo - Migraine Headache, Arterial Stiffness | Not applicable | Recruiting | Sola Aoun Bahous, M.D. Ph.D. | 160 | 2024-03-06 | 2025-11-18 |
| Role of Vitamin K2 in Chronic Kidney Disease Placebo, Vitamin K 2 - Chronic Kidney Diseases | Phase 4 | Recruiting | Tanta University | 44 | 2023-07-15 | 2025-06-24 |
| The DANish COronary DEcalcification (DANCODE) Trial Vitamin K2 (Menaquinone-7) - Coronary Artery Disease | Not applicable | Completed | Odense University Hospital | 400 | 2023-02-08 | 2026-08-26 |
| The InterVitaminK Trial - Effects of Vitamin K Supplementation on Cardiovascular, Metabolic, and Bone Health Menaquinone-7 (MK-7) tablet (333 µg), Placebo tablet - Coronary Artery Calcification, Arterial Stiffness | Not applicable | Active not recruiting | Bispebjerg Hospital | 450 | 2022-06-21 | 2026-02-17 |
| A Clinical Trial of Epizon-701 (EPN-701) in Subjects With End-Stage Renal Disease (ESRD) EPN-701 (Oral) - End-Stage Renal Disease (ESRD) | Phase 2 | Completed | Epizon Pharma, Inc. | 18 | 2019-03-01 | 2024-09-25 |
| The Aortic Valve DECalcification (AVADEC) Trial Menaquinone-7 720 µg/day including the recommended daily dose of vitamin D (25 µg/day)., Placebo - Aortic Valve Stenosis, Multidetector Computed Tomography | Not applicable | Completed | Axel Diederichsen | 389 | 2018-01-12 | 2022-09-29 |
| Decalcification of the Aortic Valve by Vitamin K2 (Menaquinone-7) Vitamin K2 (Menaquinone 7) + Vitamin D3 - Aortic Valve Disease | Phase 2 | Unknown | Hopital St. Georges, Ajaltoun | 150 | 2018-01-02 | 2019-08-09 |
| Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients Vitamin K2 (menaquinone-7; 360-mcg/d), Placebo-Control - Cardiovascular Diseases, Chronic Kidney Disease Stage 3 | Not applicable | Unknown | Augusta University | 60 | 2017-09-13 | 2019-11-20 |
| Vitamin K to Slow Progression of Dyslipidemia and Diabetes Risk (Vita-K 'n' Kids Study II) Placebo-Control, Low-Dose Vitamin K2 (menaquinone-7; 45-mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d) - Obesity, Insulin Resistance | Not applicable | Unknown | Augusta University | 30 | 2016-10-01 | 2019-11-20 |
| Treatment to Reduce Vascular Calcification in Hemodialysis Patients Using Vitamin K menaquinone-7 - Vascular Calcification, Systemic and Arterial Stiffness | Phase 2 | Completed | National University Health System, Singapore | 178 | 2016-07-01 | 2023-01-17 |
| A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes Menaquinone-7, Placebo - Arterial Calcification, Diabetes Mellitus Type 2 | Not applicable | Completed | UMC Utrecht | 68 | 2016-06-01 | 2019-10-02 |
| Vitamin K2 Effect on Vascular Stiffening in Subjects With a Poor Vitamin K-status Menaquinone-7, Placebo - Vascular Stiffness | Not applicable | Unknown | Maastricht University Medical Center | 240 | 2016-01-01 | 2018-04-30 |
| Vitamin K and Glucose Metabolism in Adults at Risk for Diabetes (Vita-K 'n' Adults Study) Placebo, Low-Dose Vitamin K2 Supplement (menaquinone-7; 90-mcg/d), High-Dose Vitamin K2 Supplement (menaquinone-7; 180-mcg/d) - Obesity, Insulin Resistance | Not applicable | Unknown | Augusta University | 30 | 2015-02-01 | 2019-11-20 |
| Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study) Placebo-Control, Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d) - Obesity, Insulin Resistance | Not applicable | Unknown | Augusta University | 30 | 2013-09-01 | 2019-11-19 |
| The Effects of Vitamin K2 Supplementation on the Progression of Coronary Artery Calcification Menaquinone-7 (Vitamin K2), Placebo capsules - Coronary Artery Disease | Not applicable | Unknown | Maastricht University Medical Center | 180 | 2011-10-01 | 2018-09-13 |
| Beneficial Effects of Long Term Menaquinone-7 menaquinone-7, placebo - Bone Loss, Arteriosclerosis | Not applicable | Completed | Maastricht University Medical Center | 240 | 2008-03-01 | 2012-06-12 |
| Effects of Omega-3 Fatty Acids and Menaquinone-7 on Thrombotic Tendency menaquinone-7, fish oil, krill oil - Atherosclerosis | Not applicable | Completed | Maastricht University Medical Center | 57 | 2008-01-01 | 2017-02-24 |
| Safety Study of Vitamin K2 During Anticoagulation in Human Volunteers acenocoumarol, menaquinone-7 - Healthy | Not applicable | Completed | Maastricht University | 20 | 2007-09-01 | 2008-03-26 |
| Dose-finding Study for Vitamin K2 in Human Volunteers Placebo, MK7 - Vitamin K-status | Not applicable | Completed | Maastricht University Medical Center | 42 | 2007-05-01 | 2018-04-27 |
| The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children menaquinone 7 - Healthy | Not applicable | Completed | UMC Utrecht | 55 | 2007-01-01 | 2008-06-10 |
Cardiovascular Diseases (3) · Insulin Resistance (3) · Obesity (3) · Coronary Artery Disease (2) · Prediabetic State (2) · Renal Insufficiency, Chronic (2) · Vitamin K Deficiency (2) · Aortic Valve Disease (1) · Aortic Valve Stenosis (1) · Arteriosclerosis (1) · Atherosclerosis (1) · Bone Diseases, Metabolic (1) · Calcinosis (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1)
Maastricht University Medical Center (5) · Augusta University (4) · UMC Utrecht (2) · Axel Diederichsen (1) · Bispebjerg Hospital (1) · Epizon Pharma, Inc. (1) · Hopital St. Georges, Ajaltoun (1) · Maastricht University (1) · National University Health System, Singapore (1) · Odense University Hospital (1) · Sola Aoun Bahous, M.D. Ph.D. (1) · Tanta University (1)
Netherlands (7) · United States (5) · Denmark (3) · Lebanon (2) · Egypt (1) · Singapore (1)
Cees Vermeer, PhD (4) · Norman K Pollock, Ph.D. (2) · Norman K Pollock, PhD (2) · Abraham Kroon, MD, PhD (1) · Axel CP Diederichsen, PhD (1) · Marjo HJ Knapen, BSc (1) · Mark T Smith, MD (1) · Peter de Leeuw, MD, PhD (1) · Sabrina Wong Peixin Haroon, MD MRCP FAMS (1) · Sola Aoun Bahous, MD, PhD (1) · Tarek Mostafa, PhD (1) · Wietse Kuis, PhD MD (1)
PMID 22136751, PMID 22289649, PMID 32899022, PMID 33068157, PMID 35465686, PMID 37208133, PMID 37451735, PMID 42268593, PMID 42661461