8 completed, 1 terminated, 1 withdrawn. 10 Phase 2, 5 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Terminated 1, Withdrawn 1 |
| Phase 3 | 5 | Completed 4, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
Follow Mefloquine: new trials by email Literature Review of Mefloquine trials Research Report on Mefloquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Mefloquine as Prophylaxis Against COVID-19: A Placebo-control, Randomized Clinical Trial Mefloquine as a prophylaxis against SARS-Cov-2 infection in household contacts of COVID 19 confirmed cases - Covid19 | Phase 2 / Phase 3 | Completed | Helwan University | 137 | 2021-03-28 | 2023-03-06 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
| Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia Artemisone/Mefloquine (AmiM3), Artesunate - Uncomplicated Falciparum Malaria | Phase 2 / Phase 3 | Withdrawn | University of Oxford | 2010-10-01 | 2018-08-31 | |
| Activity of Mefloquine Against Urinary Schistosomiasis Mefloquine, S/P - Urinary Schistosomiasis | Phase 2 | Completed | Albert Schweitzer Hospital | 65 | 2010-05-01 | 2013-01-24 |
| Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) mefloquine - Progressive Multifocal Leukoencephalopathy | Phase 1 / Phase 2 | Terminated | Biogen | 37 | 2009-01-01 | 2014-07-31 |
| Kilimanjaro IPTi Drug Options Trial sulphadoxine-pyrimethamine, mefloquine, Chlorproguanil-dapsone - Malaria | Phase 2 / Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 2419 | 2005-01-01 | 2017-01-12 |
| Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa Azithromycin/Chloroquine, Mefloquine - Malaria, Falciparum | Phase 2 / Phase 3 | Completed | Pfizer | 238 | 2004-06-01 | 2011-05-11 |
| An Evaluation of Weekly Tafenoquine Tafenoquine, Mefloquine, Placebo - Falciparum Parasitaemia | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 306 | 2000-05-01 | 2017-05-30 |
| A Randomized, Double-blind, Placebo-controlled Evaluation of Increasing Doses of Weekly Tafenoquine for Chemosuppression of Plasmodium Falciparum Placebo, Tafenoquine 25mg, Tafenoquine 50mg - Malaria | Phase 2 | Completed | U.S. Army Medical Research and Development Command | 521 | 1998-08-01 | 2018-09-13 |
Malaria (4) · Malaria, Falciparum (2) · Anemia, Sickle Cell (1) · COVID-19 (1) · Central Nervous System Diseases (1) · Leukoencephalopathy, Progressive Multifocal (1) · Pneumonia, Viral (1) · Respiratory Insufficiency (1) · Schistosomiasis haematobia (1) · Vaso-Occlusive Crises (1)
London School of Hygiene and Tropical Medicine (2) · U.S. Army Medical Research and Development Command (2) · Albert Schweitzer Hospital (1) · Biogen (1) · Burnasyan Federal Medical Biophysical Center (1) · Helwan University (1) · Pfizer (1) · University of Oxford (1)
Brazil (1) · Cambodia (1) · Egypt (1) · Gabon (1) · Germany (1) · Ghana (1) · Italy (1) · Mali (1) · Nigeria (1) · Russia (1) · Spain (1) · Tanzania (1) · Uganda (1) · United States (1) · Zambia (1)
Braden Hale, MD (1) · Brian Greenwood, FRCP, FRS (1) · Daniel Chandramohan, MBBS,PhD (1) · Duong Socheat, MD (1) · Jose Stoute, MD (1) · Kalifa Bojang, PhD (1) · Paul J Milligan, PhD (1) · Rasaq Olaosebikan, MD (1) · Roly Gosling, MBChB, MRCP (1) · Tatiana Astrelina, MD PhD,DSc. (1)
PMID 28495354, PMID 19765815, PMID 20209126, PMID 23175561, PMID 23733308, PMID 25425434, PMID 25701866, PMID 33998661