9 completed, 1 withdrawn. 10 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 9, Withdrawn 1 |
| Phase 2 | 5 | Completed 4, Withdrawn 1 |
Follow Mefloquine: new trials by email Literature Review of Mefloquine trials Research Report on Mefloquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Mefloquine as Prophylaxis Against COVID-19: A Placebo-control, Randomized Clinical Trial Mefloquine as a prophylaxis against SARS-Cov-2 infection in household contacts of COVID 19 confirmed cases - Covid19 | Phase 2 / Phase 3 | Completed | Helwan University | 137 | 2021-03-28 | 2023-03-06 |
| A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19 Mefloquine, Hydroxychloroquine, Mefloquine + azithromycin + / - tocilizumab - Pneumonia, Viral, Respiratory Failure | Phase 2 / Phase 3 | Completed | Burnasyan Federal Medical Biophysical Center | 320 | 2020-04-08 | 2021-01-27 |
| Evaluation of Artesunate-mefloquine as a Novel Alternative Treatment for Schistosomiasis in African Children Praziquantel, Artesunate + Mefloquine - Schistosoma Haematobium, Schistosoma Mansoni | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 726 | 2019-10-14 | 2021-04-05 |
| Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia Artemisone/Mefloquine (AmiM3), Artesunate - Uncomplicated Falciparum Malaria | Phase 2 / Phase 3 | Withdrawn | University of Oxford | 2010-10-01 | 2018-08-31 | |
| Prevention of Pregnancy-associated Malaria in HIV-infected Women: Cotrimoxazole Prophylaxis Versus Mefloquine cotrimoxazole, mefloquine - Malaria in Pregnancy, HIV Infections | Phase 3 | Completed | Institut de Recherche pour le Developpement | 430 | 2009-12-01 | 2013-01-23 |
| Pyronaridine - Artesunate (3:1) Versus Mefloquine Plus Artesunate in Plasmodium Falciparum Malaria Patients Pyronaridine - artesunate, Mefloquine plus artesunate - Falciparum Malaria | Phase 3 | Completed | Medicines for Malaria Venture | 1271 | 2007-01-01 | 2021-11-02 |
| Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria. Azithromycin plus Chloroquine, Mefloquine - Malaria | Phase 3 | Completed | Pfizer | 397 | 2006-11-01 | 2008-09-16 |
| Kilimanjaro IPTi Drug Options Trial sulphadoxine-pyrimethamine, mefloquine, Chlorproguanil-dapsone - Malaria | Phase 2 / Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 2419 | 2005-01-01 | 2017-01-12 |
| Azithromycin Plus Chloroquine Versus Mefloquine for the Treatment of Uncomplicated Malaria in Africa Azithromycin/Chloroquine, Mefloquine - Malaria, Falciparum | Phase 2 / Phase 3 | Completed | Pfizer | 238 | 2004-06-01 | 2011-05-11 |
| Efficacy and Safety of Dihydroartemisinin/Piperaquine (Artekin®) for the Treatment of Uncomplicated Malaria in Peru Dihydroartemisin-piperaquine, Mefloquine + Artesunate - Malaria | Phase 3 | Completed | Institute of Tropical Medicine, Belgium | 522 | 2003-07-01 | 2010-09-14 |
Malaria (5) · Malaria, Falciparum (3) · COVID-19 (1) · HIV Infections (1) · Pneumonia, Viral (1) · Respiratory Insufficiency (1) · Schistosomiasis (1) · Schistosomiasis haematobia (1)
Institute of Tropical Medicine, Belgium (2) · Pfizer (2) · Burnasyan Federal Medical Biophysical Center (1) · Helwan University (1) · Institut de Recherche pour le Developpement (1) · London School of Hygiene and Tropical Medicine (1) · Medicines for Malaria Venture (1) · University of Oxford (1)
Burkina Faso (2) · Cambodia (2) · Ghana (2) · Mali (2) · Senegal (2) · Tanzania (2) · Zambia (2) · Benin (1) · Côte d’Ivoire (1) · Egypt (1) · India (1) · Kenya (1) · Russia (1) · Thailand (1) · Uganda (1)
Brian Greenwood, FRCP, FRS (1) · Daniel Chandramohan, MBBS,PhD (1) · Duong Socheat, MD (1) · Isabelle Borghini-Fuhrer, PhD (1) · Marcel D Zannou, Professor (1) · Michel Cot, MD, PHD (1) · Moustapha Mbow, MD (1) · Pierre-Marie Girard, Professor (1) · Roly Gosling, MBChB, MRCP (1) · Tatiana Astrelina, MD PhD,DSc. (1) · Umberto D'Alessandro, MD,MSc, PHD (1)
PMID 25425434, PMID 17971864, PMID 19765815, PMID 20209126, PMID 22475593, PMID 23433102, PMID 24996807, PMID 26666916, PMID 34168029, PMID 38177851, PMID 39324693