5 completed, 2 terminated, 1 not yet recruiting. 8 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 5, Terminated 2, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Mefloquine: new trials by email Literature Review of Mefloquine trials Research Report on Mefloquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Repurposing Mefloquine for Pancreatic Cancer Treatment Mefloquine, Modified FOLFIRINOX, gemcitabine and nab paclitaxel - Pancreatic Ductal Adenocarcinoma | Phase 1 | Not yet recruiting | University of Florida | 36 | 2026-11-01 | 2026-10-15 |
| A Pharmacodynamics, Safety, and Pharmacokinetics Study of THN201 Versus Donepezil in Healthy Male Volunteers THN 201, Donepezil, Placebo - Cognitive Impairment, Alzheimer Disease | Phase 1 | Completed | Theranexus | 152 | 2018-09-27 | 2020-01-22 |
| Efficacy, Safety, and Tolerability of Dihydroartemisinin-piperaquine + Mefloquine Compared to Dihydroartemisinin-piperaquine or Artesunate-mefloquine in Patients With Uncomplicated Falciparum Malaria in Cambodia Dihydroartemisinin-piperaquine (DHA-PPQ), Mefloquine (MQ) - Acute Falciparum Malaria | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 216 | 2015-11-20 | 2019-10-10 |
| A Comparative Study of Mefloquine and S-P as Prophylaxis Against Malaria in Pregnant HIV + Patients Mefloquine, Sulphadoxine-Pyrimethamine - Malaria in Pregnant HIV + Patients | Phase 1 | Completed | ORIYOMI OMOTOYOSI AKINYOTU | 142 | 2015-09-01 | 2017-12-11 |
| Temozolomide, Memantine Hydrochloride, Mefloquine, and Metformin Hydrochloride in Treating Patients With Glioblastoma Multiforme After Radiation Therapy Mefloquine, Memantine Hydrochloride, Metformin Hydrochloride - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 144 | 2011-09-14 | 2025-05-07 |
| Intermittent Preventive Treatment for Malaria in Patient With Sickle Cell Disease Proguanil, mefloquine plus artesunate, Sulfadoxine-pyrimethamine plus amodiaquine - Malaria, Sickle Cell Crisis | Phase 1 / Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 270 | 2011-09-01 | 2014-03-21 |
| Study to Investigate the Safety, Tolerability and Pharmacokinetics of AD 452 [(+)-Mefloquine] Compared With Racemic Mefloquine AD 452 (+) mefloquine, Racemic Mefloquine, Placebo - Healthy Subjects | Phase 1 | Completed | Treague Ltd | 46 | 2009-06-01 | 2010-08-03 |
| Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML) mefloquine - Progressive Multifocal Leukoencephalopathy | Phase 1 / Phase 2 | Terminated | Biogen | 37 | 2009-01-01 | 2014-07-31 |
Malaria (3) · Alzheimer Disease (1) · Anemia, Sickle Cell (1) · Central Nervous System Diseases (1) · Cognitive Dysfunction (1) · Glioblastoma (1) · Gliosarcoma (1) · HIV Seropositivity (1) · Leukoencephalopathy, Progressive Multifocal (1) · Malaria, Falciparum (1) · Vaso-Occlusive Crises (1)
Biogen (1) · London School of Hygiene and Tropical Medicine (1) · M.D. Anderson Cancer Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · ORIYOMI OMOTOYOSI AKINYOTU (1) · Theranexus (1) · Treague Ltd (1) · University of Florida (1)
Nigeria (2) · United States (2) · Brazil (1) · Cambodia (1) · France (1) · Germany (1) · Italy (1) · Spain (1) · United Kingdom (1)
Kalifa Bojang, PhD (1) · Paul J Milligan, PhD (1) · Rasaq Olaosebikan, MD (1) · Robert Tansley, MBBS (1) · Thomas E Wellems, M.D. (1) · Vinay Puduvalli (1)