6 completed, 2 active not recruiting, 1 not yet recruiting, 1 recruiting. 10 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 6, Active not recruiting 2, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 5 | Completed 5 |
Follow mecobalamin: new trials by email Literature Review of mecobalamin trials Research Report on mecobalamin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy Mecobalamin - Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced | Phase 3 | Recruiting | Qinghai Red Cross Hospital | 326 | 2026-02-24 | 2026-04-30 |
| Mecobalamin in Promoting Recurrent Laryngeal Nerve Function Recovery After Thyroid Surgery Mecobalamin, placebo - Patients Undergoing Open Thyroid Surgery | Phase 3 | Not yet recruiting | West China Hospital | 528 | 2025-12-01 | 2025-12-10 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement Rapamycin, Naltrexone, Metformin - Healthspan Improvement, Aging | Phase 3 | Active not recruiting | AgelessRx | 30 | 2025-07-23 | 2026-03-16 |
| The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome Mecobalamin 5 MG Disintegrating Oral Tablet, placebo - Hand-foot Syndrome | Phase 3 | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 234 | 2022-01-01 | 2026-02-02 |
| Clinical Trial of Ultra-high Dose Methylcobalamin for ALS methylcobalamin, saline solution - Amyotrophic Lateral Sclerosis | Phase 3 | Completed | Eisai Co., Ltd. | 130 | 2017-11-01 | 2025-03-26 |
| Lung Function in Patients With Early Type 2 Diabetes Mellitus Calcium Dobesilate, Xuefuzhuyu Decoction, Xuefuzhuyu Decoction & Calcium dobesilate - Type 2 Diabetes Mellitus, Pulmonary Function | Phase 2 / Phase 3 | Completed | Liaoning University of Traditional Chinese Medicine | 200 | 2014-07-21 | 2017-05-30 |
| Trial of Methyl B12 on Behavioral and Metabolic Measures in Children With Autism Methyl B12, Placebo - Autistic Disorder | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 57 | 2010-01-01 | 2017-02-24 |
| A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS) E0302 (mecobalamin) - Amyotrophic Lateral Sclerosis (ALS) | Phase 2 / Phase 3 | Completed | Eisai Co., Ltd. | 135 | 2008-02-01 | 2023-06-18 |
| A Study in Patients With Amyotrophic Lateral Sclerosis (ALS) E0302 (mecobalamin), Placebo - Amyotrophic Lateral Sclerosis (ALS) | Phase 2 / Phase 3 | Completed | Eisai Co., Ltd. | 373 | 2007-04-01 | 2023-06-18 |
| Efficacy Study of Subcutaneous Methyl-B12 in Children With Autism methylcobalamin, saline placebo - Autistic Disorder | Phase 2 / Phase 3 | Completed | University of California, San Francisco | 30 | 2005-07-01 | 2019-10-09 |
Amyotrophic Lateral Sclerosis (3) · Autistic Disorder (2) · Muscular Atrophy (2) · Breast Neoplasms (1) · Child Development Disorders, Pervasive (1) · Diabetes Mellitus, Type 2 (1) · Hand-Foot Syndrome (1) · Motor Neuron Disease (1) · Peripheral Nervous System Diseases (1)
Eisai Co., Ltd. (3) · University of California, San Francisco (2) · AgelessRx (1) · Liaoning University of Traditional Chinese Medicine (1) · Qinghai Red Cross Hospital (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · West China Hospital (1)
China (3) · Japan (3) · United States (3)
Kazunori Saeki (2) · Chang Gong (1) · Jenell Decker, MD (1) · Robert L Hendren, D.O. (1) · Robert L. Hendren, DO (1) · Ryuji Kaji, MD (1) · Stefanie Morgan, PhD (1) · Xiao-lin Jiang (1)
PMID 25982504, PMID 40935571, PMID 10219748, PMID 12454521, PMID 23817134, PMID 26300733, PMID 26889605, PMID 30578206, PMID 30636701, PMID 35532908, PMID 39192360, PMID 41475066, PMID 9843082