49 completed, 16 active not recruiting, 11 terminated, 10 recruiting. 51 Phase 2, 19 Phase 3, 10 Phase 4, 8 Not applicable, 7 Phase 1.
Follow Lupron: new trials by email Literature Review of Lupron trials Research Report on Lupron
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial Abiraterone Acetate, Biospecimen Collection, Leuprolide Acetate - Recurrent Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 202 | 2026-08-04 | 2026-09-18 |
| Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CT Leuprolide, Degarelix, Relugolix - Prostate Cancer, Localized Prostate Carcinoma | Phase 2 | Recruiting | Baptist Health South Florida | 50 | 2026-07-29 | 2026-08-06 |
| Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer Darolutamide, Pembrolizumab, Lupron - Prostate Cancer, High-risk Prostate Cancer | Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 40 | 2026-05-21 | 2026-10-07 |
| Supraphysiologic Testosterone Priming Induces Darolutamide Extended Response Testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue, Darolutamide - Metastatic Castration-resistant Prostate Cancer | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 60 | 2026-03-09 | 2026-03-11 |
| The COSMYC Trial (COmbined Suppression of MYC) ZEN-3694, Testosterone cypionate, Enzalutamide - Metastatic Castration-resistant Prostate Cancer | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 50 | 2025-08-19 | 2026-06-18 |
| Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer Biopsy, Bone Scan, Computed Tomography - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 | Active not recruiting | Roswell Park Cancer Institute | 3 | 2024-12-19 | 2026-08-07 |
| Study to Test the Drug Darolutamide Along With the Drugs Leuprolide Acetate and Exemestane in Patients With Recurrent Ovarian Granulosa Cell Tumors Biospecimen Collection, Chest Radiography, Computed Tomography - Adult Ovarian Granulosa Cell Tumor | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 17 | 2024-02-08 | 2026-07-28 |
| Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer DFMO, testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue - Prostate Cancer | Phase 2 | Recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 50 | 2023-10-04 | 2026-01-14 |
| Testing the Anti-cancer Drug Darolutamide in Patients With Testosterone-Driven Salivary Gland Cancers Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Salivary Gland Carcinoma, Metastatic Salivary Gland Carcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2023-07-20 | 2026-07-31 |
| RElugolix VErsus LeUprolide Cardiac Trial Radiation therapy, Leuprolide, Relugolix - Biochemically Recurrent Prostate Carcinoma, Localized Prostate Carcinoma | Phase 2 | Active not recruiting | Emory University | 94 | 2022-06-06 | 2026-02-12 |
| Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer Abiraterone Acetate, Bicalutamide, Degarelix - Castration-Sensitive Prostate Carcinoma, Metastatic Prostate Adenocarcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 70 | 2021-05-04 | 2026-01-28 |
| Antiandrogen Therapy and SBRT in Treating Patients With Recurrent, Metastatic Prostate Cancer Abiraterone Acetate, Apalutamide, Leuprolide Acetate - Metastatic Prostate Adenocarcinoma, Prostate Adenocarcinoma With Focal Neuroendocrine Differentiation | Phase 2 | Active not recruiting | Jonsson Comprehensive Cancer Center | 28 | 2021-03-17 | 2026-02-05 |
| Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study Darolutamide, Goserelin Acetate, Leuprolide Acetate - Prostate Carcinoma | Phase 3 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 27 | 2021-03-01 | 2026-07-28 |
| Androgen Deprivation Therapy and Apalutamide With or Without Radiation Therapy for the Treatment of Biochemically Recurrent Prostate Cancer, RESTART Study Apalutamide, Degarelix, Leuprolide Acetate - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2020-11-24 | 2021-01-20 | |
| Bariatric Arterial Embolization for Men Starting Hormones for Prostate Cancer Bead Block 300-500 um, Weight Management, Lupron - Prostate Adenocarcinoma, Obesity, Morbid | Phase 2 | Withdrawn | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2020-11-16 | 2022-05-02 | |
| Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging 3-Dimensional Conformal Radiation Therapy, Apalutamide, Computed Tomography - Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 804 | 2020-10-08 | 2026-08-19 |
| Skeletal Health and Bone Marrow Composition Among Youth GnRH Agonist - Gender Dysphoria in Children, Puberty | Not applicable | Terminated | Amy DiVasta, MD | 78 | 2020-09-15 | 2026-04-03 |
| Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model Leuprolide Acetate 3.75 MG/ML, Estradiol 2 Mg tablet, Micronized progesterone - Perinatal Depression, Post Partum Depression | Phase 2 | Completed | University of North Carolina, Chapel Hill | 23 | 2020-01-02 | 2023-08-25 |
| Defining Recurrent Disease With Axumin™ Casodex, Axumin, Salvage Radiation, Axumin - Prostate Cancer, Prostate Adenocarcinoma | Unknown | Cancer Center of Irvine | 20 | 2019-07-01 | 2019-06-25 | |
| REGN2810 Followed by Chemoimmunotherapy for Newly Metastatic Hormone-sensitive Prostate Cancer REGN2810, Degarelix, Leuprolide Acetate - Prostate Cancer Metastatic | Phase 2 | Active not recruiting | Mark Stein | 26 | 2019-05-16 | 2025-04-25 |
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Prostatic Neoplasms (51) · Infertility (5) · Obesity (4) · Puberty, Precocious (4) · Breast Neoplasms (3) · Depression, Postpartum (3) · Neoplasms (3) · Depression (2) · Hot Flashes (2) · Insulin Resistance (2) · Lymphoma, Non-Hodgkin (2) · Metabolic Syndrome (2) · Multiple Myeloma (2) · Myelodysplastic Syndromes (2) · Polycystic Ovary Syndrome (2)
National Cancer Institute (NCI) (8) · M.D. Anderson Cancer Center (7) · University of Colorado, Denver (5) · Abbott (4) · Mayo Clinic (4) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (4) · City of Hope Medical Center (3) · Ferring Pharmaceuticals (3) · University of Washington (3) · Dana-Farber Cancer Institute (2) · ECOG-ACRIN Cancer Research Group (2) · Icahn School of Medicine at Mount Sinai (2) · Massachusetts General Hospital (2) · Memorial Sloan Kettering Cancer Center (2) · Radiation Therapy Oncology Group (2)
United States (89) · Canada (8) · Puerto Rico (6) · Czechia (3) · Mexico (3) · Netherlands (3) · United Kingdom (3) · Brazil (2) · Germany (2) · Hungary (2) · Romania (2) · Russia (2) · Ukraine (2) · Australia (1) · Austria (1)
Christopher Logothetis (3) · Celestia Higano, MD (2) · Samuel Denmeade, MD (2) · Alan L Ho (1) · Alicia K Morgans (1) · Amado Zurita, MD (1) · Amar Kishan (1) · Andrew K. Lee, MD (1) · Ann Partridge, MD (1) · Anne R. Cappola, MD, ScM (1) · Antonios Likourezos, M.P.H., M.A. (1) · Asha Baxi, MD, FRCOG (1) · Ashutosh K Tewari, MD (1) · Brian Chapin (1)
PMID 20818327, PMID 34350976, PMID 38320143, PMID 38421243, PMID 18172212, PMID 18309951, PMID 18647805, PMID 19012911, PMID 19035858, PMID 21123449, PMID 21751904, PMID 21860633, PMID 22006050, PMID 22025196, PMID 22344198, PMID 22723326, PMID 24293774, PMID 24926950, PMID 25242417, PMID 25283586, PMID 25385669, PMID 25534388, PMID 25847934, PMID 26951410, PMID 27680875, PMID 29248669, PMID 29457758, PMID 29631362, PMID 33496795, PMID 33683939, PMID 34385241, PMID 34481017, PMID 36782063, PMID 37119051, PMID 37372414, PMID 37851874, PMID 37922910, PMID 38161319, PMID 38320501, PMID 38421252, PMID 38494380, PMID 38833643, PMID 39074346, PMID 39621968, PMID 39670843, PMID 40140551, PMID 40907514, PMID 41124201, PMID 41349040, PMID 41364813
P30CA015083 (2), P30CA033572 (2), U10CA032102 (2), U10CA180820 (2), U10CA180868 (2), K23AG019161 (1), M01RR000064 (1), N01CM00039 (1), N01CM62201 (1), N01CM62202 (1), N01CM62205 (1), N01CM62206 (1), P30CA008748 (1), P30CA015704 (1), P30CA016672 (1)