7 completed, 3 unknown, 2 active not recruiting, 2 terminated. 15 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 15 | Completed 7, Unknown 3, Active not recruiting 2, Terminated 2, Suspended 1 |
| Phase 2 | 4 | Completed 2, Terminated 1, Unknown 1 |
Follow L-carnitine: new trials by email Literature Review of L-carnitine trials Research Report on L-carnitine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men L-carnitine - Oligoasthenozoospermia, Male Infertility | Phase 3 | Active not recruiting | South Valley University | 50 | 2026-01-01 | 2026-02-11 |
| Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia. Letrozole 2.5mg, L-carnitine - Idiopathic Oligoasthenoteratozoospermia, Male Infertility | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 90 | 2023-12-01 | 2026-06-30 |
| Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma Biospecimen Collection, Calaspargase Pegol, Levocarnitine - B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Phase 3 | Active not recruiting | Children's Oncology Group | 440 | 2023-08-24 | 2026-08-21 |
| L-carnitine in Modulating Pain and Inflammation in Rheumatoid Arthritis L-carnitine - Rheumatoid Arthritis | Phase 3 | Unknown | Tanta University | 46 | 2023-03-05 | 2023-03-31 |
| L-carnitine vs Placebo for the Treatment of Muscle Cramps After Imatinib in Gastrointestinal Stromal Tumors L-carnitine, Placebo - Gastrointestinal Stromal Tumors (GISTs) | Phase 3 | Completed | Asan Medical Center | 4 | 2018-03-01 | 2020-07-13 |
| L-carnitine Corrects Ammonia Metabolism in Hepatectomized Patients L-carnitine, usual intake - Ammonia Metabolism | Phase 2 / Phase 3 | Unknown | Kochi University | 80 | 2016-04-01 | 2017-01-16 |
| Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration Hydration strategy using saline, Hydration strategy using sodium bicarbonate, L-carnitine - Acute Kidney Injury, Renal Insufficiency | Phase 3 | Terminated | Centre Hospitalier Universitaire de Nīmes | 9 | 2014-12-01 | 2016-03-22 |
| L-carnitine on the Prevention of Renal Scarring in Acute Pyelonephritis L-carnitine - Acute Pyelonephritis(APN) | Phase 3 | Unknown | Shahid Beheshti University | 78 | 2013-11-01 | 2013-12-11 |
| Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants L-carnitine, 5% Dextrose - Prematurity, Neurodevelopmental Disorder | Phase 2 / Phase 3 | Completed | Montefiore Medical Center | 144 | 2013-01-01 | 2023-03-08 |
| Efficacy of L-carnitine Versus Placebo in the Treatment of Fatigue in Multiple Sclerosis L-Carnitine, Placebo - Multiple Sclerosis | Phase 3 | Completed | University Hospital, Bordeaux | 59 | 2010-06-01 | 2026-05-12 |
| Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures Vitamin C, L-Carnitine, Placebo - Atrial Fibrillation | Phase 3 | Completed | Attikon Hospital | 33 | 2010-04-01 | 2015-10-19 |
| Early Administration of L-carnitine in Hemodialysis Patients L-Carnitine - Complication of Hemodialysis, Hyperthyroidism Treated or Under Control | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 110 | 2006-06-01 | 2011-05-04 |
| L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN) L-Carnitine, Placebo - Pancreatic Carcinoma | Phase 3 | Suspended | University Medicine Greifswald | 72 | 2006-06-01 | 2011-04-07 |
| Ability of L-carnitine to Prevent Heart Damage in Breast Cancer Patients Receiving Anthracycline Chemotherapy L-carnitine - Heart Failure | Phase 2 / Phase 3 | Terminated | Ottawa Heart Institute Research Corporation | 36 | 2006-03-01 | 2022-08-16 |
| The Safety and Effectiveness of Adefovir Dipivoxil in the Treatment of HIV-Infected Patients Levocarnitine, Adefovir dipivoxil, Adefovir dipivoxil placebo - Cytomegalovirus Infections, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 505 | 1996-12-01 | 2013-10-01 |
Infertility, Male (2) · Acute Kidney Injury (1) · Anemia (1) · Arthritis, Rheumatoid (1) · Atrial Fibrillation (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Cytomegalovirus Infections (1) · Fatigue (1) · Gastrointestinal Stromal Tumors (1) · HIV Infections (1) · Heart Failure (1) · Leukemia, Biphenotypic, Acute (1) · Malnutrition (1) · Multiple Sclerosis (1)
Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Attikon Hospital (1) · Centre Hospitalier Universitaire de Nīmes (1) · Children's Oncology Group (1) · Kochi University (1) · Montefiore Medical Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Ottawa Heart Institute Research Corporation (1) · Shahid Beheshti University (1) · South Valley University (1) · Tanta University (1) · Tehran University of Medical Sciences (1) · University Hospital, Bordeaux (1) · University Medicine Greifswald (1)
France (3) · United States (3) · Canada (2) · Egypt (2) · Iran (2) · Germany (1) · Greece (1) · Japan (1) · South Korea (1)
Alaleh Gheisari (1) · Azadeh Eshraghi, Clinical Pharmacist (1) · Azim Hedayatpour, Professor, PhD (1) · Benjamin JW Chow, MD, FRCPC (1) · Brosgart C (1) · Eisa Mohammed Hegazy (1) · Etan Orgel (1) · Fisher E (1) · George Wells, M.Sc., PhD (1) · Golnaz Vaseghi, Ph.D pharmacology (1) · Haissam Haddad, MD, FRCPC (1) · Ioannis Toumpoulis, MD (1) · Lucile Mercadal, MD,PhD (1)
PMID 19446899, PMID 30408788, PMID 31599019, PMID 31628586, PMID 36472884, PMID 39498822
2009 (1), U24CA196173 (1), UG1CA189955 (1)