33 completed, 12 unknown, 5 active not recruiting, 5 terminated. 20 Phase 2, 19 Not applicable, 15 Phase 3, 8 Phase 4, 3 Phase 1.
Follow L-carnitine: new trials by email Literature Review of L-carnitine trials Research Report on L-carnitine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Omega-DEK in Childhood Apraxia of Speech Omega-DEK, L-carnitine, Placebo - Childhood Apraxia of Speech, Verbal Apraxia | Phase 2 | Not yet recruiting | Claudia R. Morris | 34 | 2026-11-01 | 2026-07-29 |
| Effect of L-Carnitine Supplementation in Preterm Neonates L-carnitine, Standard care - Respiratory Distress Syndrome | Not applicable | Recruiting | Muhammad Aamir Latif | 160 | 2026-01-01 | 2026-02-27 |
| Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men L-carnitine - Oligoasthenozoospermia, Male Infertility | Phase 3 | Active not recruiting | South Valley University | 50 | 2026-01-01 | 2026-02-11 |
| Levocarnitine for Reducing ESA Requirements in Hemodialysis Patients With Renal Anemia Levocarnitine Injection, Usual ESA-Based Anemia Care - Anemia, Kidney Failure | Phase 4 | Not yet recruiting | Shaikh Zayed Hospital, Lahore | 94 | 2025-09-15 | 2025-09-12 |
| A Study to Improve Skeletal Muscle in Veterans With HIV w-3 fatty acid, L-carnitine, Control Diet - HIV, Obesity | Not applicable | Recruiting | VA Office of Research and Development | 70 | 2025-07-15 | 2026-06-26 |
| Effect of L-carnitine on Disease Activity in Patients With Mild to Moderate Knee Osteoarthritis L-carnitine, Placebo - Knee Osteoarthritis | Phase 2 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 66 | 2025-06-28 | 2026-02-06 |
| Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI L-Carnitine, The standard care for the management of myocardial infarction post PCI - Reperfusion Injury, Myocardial, Myocardial Infarction | Phase 2 | Active not recruiting | Ain Shams University | 76 | 2025-06-01 | 2026-09-01 |
| Effects of Carnitine Supplementation on Exercise-Induced Muscle Damage: A Randomized Controlled Trial L-Carnitine, Placebo - Recovery Methods, Exercise and Recovery | Not applicable | Completed | Istanbul Sabahattin Zaim University | 30 | 2025-05-09 | 2026-03-25 |
| Effect of L-carnitine Supplementation on Phenylalanine and Brain-derived Neurotrophic Factor Levels in Infants and Children With Phenylketonuria L-carnitine - Phenylketonuria | Phase 4 | Active not recruiting | Mansoura University | 176 | 2025-02-01 | 2025-04-04 |
| Enhancing the Effects of Alcohol Treatment With L-Carnitine L-carnitine - Alcohol Use Disorder | Phase 1 | Completed | Brown University | 24 | 2024-09-27 | 2025-06-15 |
| Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment l-carnitine - Teratozoospermia | Not applicable | Unknown | South Valley University | 126 | 2024-09-01 | 2025-06-12 |
| Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia. Letrozole 2.5mg, L-carnitine - Idiopathic Oligoasthenoteratozoospermia, Male Infertility | Phase 2 / Phase 3 | Completed | Tehran University of Medical Sciences | 90 | 2023-12-01 | 2026-06-30 |
| Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphoma Biospecimen Collection, Calaspargase Pegol, Levocarnitine - B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Phase 3 | Active not recruiting | Children's Oncology Group | 440 | 2023-08-24 | 2026-08-21 |
| Carnitine Supplementation in Pediatric Hemodialysis Patients L-carnitine, isotonic saline - Carnitine Deficiency Due to Hemodialysis | Early Phase 1 | Unknown | Ain Shams University | 40 | 2023-08-01 | 2023-07-17 |
| Using Gut Microbial Gbu Gene Testing to Estimate Host TMAO Production Capacity L-carnitine - Gut Dysbiosis for TMAO Production From L-carnitine Consumption | Not applicable | Active not recruiting | National Taiwan University Hospital | 230 | 2023-07-24 | 2026-01-12 |
| The Efficacy of L-Carnitine in the Management of Acute Clozapine Intoxication L-Carnitine - Clozapine Poisoning | Phase 2 | Unknown | Alexandria University | 40 | 2023-06-01 | 2022-12-02 |
| L-carnitine in Modulating Pain and Inflammation in Rheumatoid Arthritis L-carnitine - Rheumatoid Arthritis | Phase 3 | Unknown | Tanta University | 46 | 2023-03-05 | 2023-03-31 |
| The Efficacy of L-Carnitine in the Management of Acute Carbon Monoxide Poisoning L-Carnitine - Carbon Monoxide Poisoning | Phase 2 | Unknown | Alexandria University | 72 | 2022-12-15 | 2022-12-12 |
| Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance L-carnitine, L-leucine, Change of the circadian cycle - Insulin Resistance | Not applicable | Completed | Poznan University of Physical Education | 40 | 2022-02-07 | 2026-08-17 |
| Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension L-carnitine - Pulmonary Arterial Hypertension, Familial Primary Pulmonary Hypertension | Phase 1 | Completed | Vanderbilt University Medical Center | 10 | 2021-09-29 | 2025-09-30 |
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HIV Infections (4) · Fatigue (3) · Kidney Failure, Chronic (3) · Obesity (3) · Renal Insufficiency (3) · Acquired Immunodeficiency Syndrome (2) · Anemia (2) · Diabetes Mellitus, Type 2 (2) · Hyperlipidemias (2) · Infertility, Male (2) · Insulin Resistance (2) · Motor Activity (2) · Muscular Atrophy (2) · Polycystic Ovary Syndrome (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2)
Ain Shams University (2) · Alexandria University (2) · Assiut University (2) · Gdansk University of Physical Education and Sport (2) · Iperboreal Pharma Srl (2) · Poznan University of Physical Education (2) · South Valley University (2) · Tanta University (2) · Tehran University of Medical Sciences (2) · University of California, Davis (2) · Asan Medical Center (1) · Assistance Publique - Hôpitaux de Paris (1) · Attikon Hospital (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Brown University (1)
United States (18) · Egypt (9) · France (4) · Iran (4) · Canada (3) · Germany (2) · Italy (2) · Poland (2) · South Korea (2) · Bangladesh (1) · Greece (1) · Japan (1) · Mexico (1) · Pakistan (1) · Taiwan (1)
Lars Berglund, MD, PhD (2) · Robert Olek, PhD (2) · Alaa M Ismail, M.D (1) · Alaleh Gheisari (1) · Alan E Jones, MD (1) · Andrea Townson, MD (1) · Anna R Hemnes (1) · Anne Lynn Chang (1) · Arduino Arduini, M.D. (1) · Arduino Arduini, MD (1) · Athar Razzaq, FCPS (1) · Azadeh Eshraghi, Clinical Pharmacist (1) · Azim Hedayatpour, Professor, PhD (1) · Benjamin JW Chow, MD, FRCPC (1) · Brosgart C (1)
PMID 36472884, PMID 19446899, PMID 21525850, PMID 22615190, PMID 26825368, PMID 27432821, PMID 30408788, PMID 31273783, PMID 31599019, PMID 31628586, PMID 33536102, PMID 37533033, PMID 39498822, PMID 39722590
2009 (1), P30CA124435 (1), R21AA029033 (1), U24CA196173 (1), UG1CA189955 (1)