45 completed, 12 unknown, 5 withdrawn, 4 recruiting. 21 Not applicable, 18 Phase 2, 13 Phase 3, 9 Phase 4, 8 Phase 1.
Follow L-arginine: new trials by email Literature Review of L-arginine trials Research Report on L-arginine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery L-arginine - Acute Kidney Injury | Not yet recruiting | Xijing Hospital | 5000 | 2026-07-20 | 2026-08-10 | |
| Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients L-Arginine, Placebo - Cognition Disorders in Old Age, Cognitive and Behavioral Impairment | Phase 2 | Recruiting | German University in Cairo | 60 | 2025-08-27 | 2026-01-21 |
| Efficacy Of Supplemental L-Arginine in Preventing Preeclampsia in Pregnant Women L-Arginine, placebo - Pre-eclampsia | Not applicable | Completed | Quaid-e-Azam Medical College | 108 | 2025-07-01 | 2026-11-03 |
| Acute Effects of Creatine and L-Arginine Co-Supplementation on Anaerobic and Cognitive Performance in Recreationally Active Males Creatine Monohydrate, L-Arginine, Placebo - Anaerobic Performance, Cognitive Performance | Not applicable | Completed | Inonu University | 18 | 2025-04-01 | 2026-04-23 |
| Acute Effects of BCAA and L-Arginine on Performance in Elite Soccer Players BCAA, L-Arginine, bcaa and l arginine - Ergogenic Support and Performance | Not applicable | Completed | Ataturk University | 21 | 2025-01-10 | 2026-01-16 |
| Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases Arginine, Biospecimen Collection, Computed Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Early Phase 1 | Recruiting | Emory University | 10 | 2024-09-05 | 2026-10-13 |
| Myoinositol, L-arginine and Chromium With Letrozole for Ovulation Induction in Polycystic Ovarian Syndrome Patients Myoinositol, Chromium, l-arginine - Polycystic Ovary Syndrome | Phase 3 | Unknown | Beni-Suef University | 100 | 2024-06-30 | 2024-05-08 |
| The Effects of L-arginine Supplementation on Anaerobic Exercise Performance L-arginine, Placebo - Skeletal Muscle, Human Performance | Not applicable | Unknown | University of Manitoba | 20 | 2024-06-14 | 2024-06-26 |
| EFFECTS OF L-ARGININE SUPPLEMENTATION ON THE RECOVERY OF CARDIORESPIRATORY PARAMETERS AFTER SUBMAXIMAL EXERCISE TEST L-arginine, Placebo - Nutrition, Healthy | Not applicable | Unknown | Universidade Estadual Paulista Júlio de Mesquita Filho | 35 | 2024-02-15 | 2024-05-08 |
| Safety And Efficacy Of L-Arginine Monotherapy Versus Tadalafil Monotherapy Versus Their Combination In Men With Erectile Dysfunction; A Prospective Randomized Study L-Arginine, Tadalafil 5 mg - Erectile Dysfunctions | Phase 4 | Completed | Fayoum University Hospital | 180 | 2024-01-14 | 2025-04-27 |
| Arginine Replacement Therapy in COVID-19 Arginine Hydrochloride - COVID-19 | Phase 2 | Recruiting | Emory University | 21 | 2024-01-08 | 2026-04-15 |
| L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) L-citrulline - Pregnancy, Malaria | Not applicable | Recruiting | Liverpool School of Tropical Medicine | 2960 | 2023-12-29 | 2025-06-27 |
| Effect of the Administration of L-arginine vs. Placebo in Patients Diagnosed With Presbyvestibulopathy. L-arginine, Placebo - Presbyvestibulopathy | Phase 2 | Withdrawn | Centro Universitario de Tonalá | 2023-05-02 | 2024-02-15 | |
| L-Arginine in Children Having Sickle Cell Disease With Increased Tricuspid Regurgitant Jet Velocity L-Arginine - Sickle Cell Disease | Phase 3 | Completed | Tanta University | 50 | 2022-07-25 | 2026-01-22 |
| The Effects of ATLAS Therapy on Nitric Oxide Bioavailability in Patients With Intermittent Claudication Tetrahydrobiopterin 10 mg/kg, Tetrahydrobiopterin 20 mg/kg, L-Ascorbate - Claudication, Intermittent, Peripheral Artery Disease | Phase 1 | Active not recruiting | Louis Messina | 10 | 2021-06-15 | 2026-04-15 |
| Managing Endothelial Dysfunction in COVID-19 : A Randomized Controlled Trial at LAUMC Atorvastatin + L-arginine + Folic acid + Nicorandil + Nebivolol, Placebo - Covid19 | Phase 3 | Unknown | Lebanese American University Medical Center | 42 | 2021-01-10 | 2022-02-14 |
| Role of L-Arginine Supplementation in the Treatment of Rheumatoid Arthritis L-arginine, Placebo - Rheumatoid Arthritis | Phase 2 | Unknown | RenJi Hospital | 144 | 2021-01-01 | 2020-09-02 |
| L-arginine Study for Persistent Symptoms of Schizophrenia L-arginine, Sapropterin Dihydrochloride - Schizo Affective Disorder, Schizophrenia | Phase 2 | Withdrawn | University of Massachusetts, Worcester | 2019-09-11 | 2022-01-20 | |
| Effects of Dietary Supplement on Osteoarthritis L-arginine - Knee Osteoarthritis | Not applicable | Unknown | Memorial University of Newfoundland | 38 | 2019-03-05 | 2023-07-14 |
| Nutritional Supplements and Nitric Oxide Bioactivity L-Arginine, Nitrate / Nitrite, Placebo - Nitric Oxide, Vascular Function | Not applicable | Completed | Maastricht University Medical Center | 20 | 2018-12-01 | 2020-02-20 |
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Cardiovascular Diseases (5) · Hypertension (5) · Anemia, Sickle Cell (4) · Diabetes Mellitus, Type 2 (3) · Glucose Intolerance (3) · Peripheral Vascular Diseases (3) · Pre-Eclampsia (3) · Schizophrenia (3) · Asthma (2) · COVID-19 (2) · Cognitive Dysfunction (2) · Erectile Dysfunction (2) · Hypertension, Pregnancy-Induced (2) · Inflammation (2) · Insulin Resistance (2)
Emory University (3) · Maastricht University Medical Center (3) · Brigham and Women's Hospital (2) · IRCCS San Raffaele (2) · Mayo Clinic (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · The Hospital for Sick Children (2) · The University of Texas at Arlington (2) · University of Massachusetts, Worcester (2) · University of Modena and Reggio Emilia (2) · Ain Shams University (1) · Assistance Publique - Hôpitaux de Paris (1) · Ataturk University (1) · Beni-Suef University (1) · Boston University (1)
United States (21) · Egypt (6) · Canada (5) · Italy (5) · Brazil (4) · Germany (3) · Turkey (Türkiye) (3) · Mexico (2) · Netherlands (2) · China (1) · France (1) · Indonesia (1) · Israel (1) · Kenya (1) · Lebanon (1)
PierMarco Piatti, MD (2) · Alfredo H Navigante, MD, Phd (1) · Anna P Ralph, MBBS (1) · Claudia Morris, MD (1) · Claudia R. Morris, MD (1) · Daniel A Bottino, PhD (1) · Diane Cox, Ph.D. (1) · Dina B Lolong, MD (1) · Dirk Fischer, MD (1) · Dirk O. Stichtenoth, MD (1) · Eduardo Podjarny, MD (1) · Edward Jude, MD, MRCP (1) · Elizabeth R DeGrush, DO (1) · Eman El-Khateeb, Msc (1) · Emiliana Tjitra, MD, PhD (1)
PMID 10851208, PMID 11927799, PMID 12119802, PMID 12923400, PMID 15198963, PMID 15738343, PMID 16391172, PMID 16391217, PMID 16533484, PMID 17636753, PMID 18426998, PMID 18626628, PMID 19047577, PMID 19738158, PMID 20484311, PMID 22801444, PMID 23266540, PMID 23333044, PMID 23778831, PMID 23830159, PMID 23967066, PMID 25861285, PMID 25993630, PMID 26385052, PMID 26799743, PMID 28366306, PMID 29052766, PMID 30070030, PMID 30260460, PMID 30377712, PMID 31701693, PMID 32384147, PMID 32497023, PMID 32842812, PMID 32881886, PMID 33586138, PMID 34724240, PMID 36115980, PMID 37319354, PMID 39385595, PMID 40270092, PMID 40389021, PMID 40526198, PMID 42549972, PMID 42783813, PMID 7519783, PMID 9095088, PMID 9369256, PMID 9890307
2005 (1), K24AT009893 (1), P01AI050153 (1), P30CA016672 (1), P30CA138292 (1), P50HL083800 (1), R01AG015466 (1), R01HL063685 (1), R01HL070059 (1), R01HL075774 (1), R01HL105573 (1), R21AT004174 (1), T32HL007708 (1), U10CA081851 (1), UL1RR024146 (1)