7 completed, 2 unknown, 1 withdrawn. 8 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 5, Unknown 2, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
Follow Isoleucine: new trials by email Literature Review of Isoleucine trials Research Report on Isoleucine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Isoleucine Addition Treatment Effects in a Controlled Diet Study L-Isoleucine, Low-isoleucine diet - Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS) | Not applicable | Withdrawn | Jean L. Fry | 2026-05-04 | 2026-04-15 | |
| Liquid Valine and Isoleucine in Maple Syrup Urine Disease Valine oral solution (50mg/ml) and isoleucine oral solution (25mg/ml) - Maple Syrup Urine Disease | Not applicable | Unknown | Meta Healthcare Ltd | 5 | 2024-10-01 | 2024-09-03 |
| Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic Control Quinine, L-isoleucine, Combination of quinine and L-isoleucine - Healthy | Not applicable | Completed | University of Adelaide | 15 | 2023-06-19 | 2024-12-10 |
| Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity Cellulose (control), Glycine, Alanine - Atherosclerosis, Diet Modification | Not applicable | Unknown | Rambam Health Care Campus | 110 | 2017-07-01 | 2017-06-08 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Dietary Intake and Circulating Levels of Branched Chain Amino Acids Diet high in amino acid levels, Diet low in amino acid levels - Dietary Intake of Branched Chain Amino Acids | Not applicable | Completed | Massachusetts General Hospital | 5 | 2014-04-01 | 2016-10-07 |
| The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients Branched Chained Amino Acids, Cellulose Placebo mix - Type 2 Diabetes, Healthy Individuals | Not applicable | Completed | Loma Linda University | 50 | 2010-10-01 | 2011-04-22 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
| Isoleucine Added ORS in Children With Diarrhoea ORS + Isoleucine, ORS without Isoleucine - Acute Infectious Diarrhoea in Children | Phase 2 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 50 | 2007-07-01 | 2009-12-17 |
Atherosclerosis (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Diarrhea (1) · Disease (1) · Glucose Intolerance (1) · Hyperglycemia (1) · Insulin Resistance (1) · Maple Syrup Urine Disease (1) · Memory Disorders (1) · Metabolic Syndrome (1) · Muscular Atrophy (1) · Obesity (1) · Osteoarthritis (1) · Overweight (1)
University of Oregon (2) · International Centre for Diarrhoeal Disease Research, Bangladesh (1) · Jean L. Fry (1) · Loma Linda University (1) · Massachusetts General Hospital (1) · Meta Healthcare Ltd (1) · Rambam Health Care Campus (1) · University of Adelaide (1) · University of Colorado, Denver (1)
United States (6) · Australia (1) · Bangladesh (1)
Anita MacDonald (1) · Christine Feinle-Bisset, PhD (1) · Cynthia Neill Epperson, M.D. (1) · Geoffrey Walford, M.D. (1) · Hans C Dreyer, PT, PhD (1) · Jean Fry, PhD (1) · Jerrold Petrofsky, Doctoral PhD (1) · Tony Hayek, Prof (1)
PMID 12449285, PMID 17364057, PMID 21766553, PMID 22204954, PMID 24135139, PMID 24401239, PMID 26733251, PMID 26781817, PMID 26829246, PMID 30280129, PMID 31343947, PMID 41365468
K01HD057332 (1), P20GM156679 (1), P50MH099910 (1), R01AG046401 (1)