35 completed, 9 unknown, 5 terminated, 2 recruiting. 22 Phase 2, 19 Not applicable, 7 Phase 1, 4 Early Phase 1, 3 Phase 3.
Follow Intranasal oxytocin: new trials by email Literature Review of Intranasal oxytocin trials Research Report on Intranasal oxytocin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oxytocin's Effects on Real Time-fMRI Neurofeedback Training of Anterior Insula Activity Intranasal oxytocin, Intranasal placebo - Healthy | Not applicable | Recruiting | University of Electronic Science and Technology of China | 80 | 2026-04-26 | 2026-04-30 |
| The Power of Belief: Expectation-driven and Placebo Modulation of Empathic Pain Intranasal Oxytocin (OT) 24 IU, Intranasal placebo administration - Healthy Participants | Not applicable | Recruiting | University of Electronic Science and Technology of China | 120 | 2025-12-01 | 2026-01-26 |
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| Oxytocin's Effect on the Advantageous- and Disadvantageous-inequity Intranasal oxytocin, Intranasal placebo - Healthy | Not applicable | Completed | University of Electronic Science and Technology of China | 80 | 2024-01-07 | 2024-08-14 |
| Common and Differentiated Representations Between Social Exclusion and Social Separation Intranasal Oxytocin, Intranasal Arginine Vasopressin, Intranasal placebo - Healthy | Not applicable | Unknown | University of Electronic Science and Technology of China | 120 | 2023-04-20 | 2023-06-28 |
| The Effects of Oxytocin Administration to Patients and Therapists on Physiological Synchronization Intranasal Oxytocin - Severe Mental Illness | Phase 2 | Unknown | Shalvata Mental Health Center | 120 | 2023-03-30 | 2024-06-28 |
| A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects intravenous oxytocin, intranasal oxytocin - Healthy Volunteer Study | Phase 1 | Completed | Wake Forest University Health Sciences | 25 | 2023-02-27 | 2025-02-17 |
| A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine TNX-1900, Placebo Nasal Spray - Chronic Migraine, Chronic Migraine, Headache | Phase 2 | Completed | Tonix Pharmaceuticals, Inc. | 88 | 2022-12-06 | 2025-02-25 |
| The Effects of Intranasal and Oral Administration of Oxytocin on Responses to Emotional Scenes Oral Oxytocin, Intranasal Oxytocin, Oral placebo - Healthy | Not applicable | Unknown | University of Electronic Science and Technology of China | 160 | 2022-09-20 | 2022-09-08 |
| Does Oxytocin Alter Tolerance to or Motivation for Alcohol Intranasal oxytocin, Intranasal placebo - Alcohol Use Disorder | Phase 2 | Terminated | Indiana University | 6 | 2022-01-16 | 2025-03-04 |
| The Effects of Oxytocin Treatment on Social Touch Intranasal oxytocin, Oral oxytocin, Placebo - Healthy | Not applicable | Completed | University of Electronic Science and Technology of China | 180 | 2021-09-01 | 2023-05-11 |
| Effects of Oxytocin on Reinforcement Learning and Interoception Intranasal oxytocin, intranasal placebo - Healthy | Not applicable | Completed | University of Electronic Science and Technology of China | 80 | 2021-04-15 | 2024-01-19 |
| Inhaled Oxytocin and HPA Axis Reactivity Intranasal Oxytocin, Placebo - Depression, Postpartum, Anxiety Disorders | Phase 2 | Completed | University of North Carolina, Chapel Hill | 109 | 2019-02-07 | 2025-08-08 |
| Umbilical Cord Blood vs Personalized Treatments for Improving Autistic Disorder Intranasal oxytocin, Autologous umbilical cord blood - Autistic Spectrum Disorder | Phase 1 | Completed | Fundatia Bio-Forum | 35 | 2019-01-17 | 2023-08-23 |
| Effects of Oxytocin on Reinforcement Learning intranasal oxytocin, intranasal placebo - Learning Disabilities | Not applicable | Unknown | University of Electronic Science and Technology of China | 40 | 2018-12-04 | 2019-02-19 |
| Probiotics and Oxytocin Nasal Spray on Social Behaviors of Autism Spectrum Disorder (ASD) Children intranasal oxytocin, oral probiotics, oral placebo - Autism Spectrum Disorder | Phase 1 | Completed | Massachusetts General Hospital | 35 | 2018-12-01 | 2020-03-04 |
| The Impact of Oxytocin on the Neurobiology of Anorexia Nervosa Intranasal oxytocin - Anorexia Nervosa | Early Phase 1 | Completed | University of Minnesota | 16 | 2018-09-25 | 2022-02-11 |
| Intranasal Oxytocin and Food Intake in Obese Adolescents Syntocinon, Placebo - Obesity | Phase 2 | Withdrawn | Shana McCormack, MD | 2018-09-01 | 2018-12-26 | |
| Intranasal Oxytocin as Enhancer of Psychotherapy Outcomes in Severe Mental Illness Intranasal Oxytocin, Intranasal Placebo - Severe Mental Illness | Phase 2 | Unknown | Shalvata Mental Health Center | 120 | 2018-06-01 | 2024-06-28 |
| Intranasal Oxytocin for Frontotemporal Dementia Syntocinon - Frontotemporal Dementia | Phase 2 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 112 | 2018-01-31 | 2023-12-15 |
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Autism Spectrum Disorder (10) · Anxiety Disorders (4) · Diabetes Insipidus (4) · Autistic Disorder (3) · Frontotemporal Dementia (3) · Schizophrenia (3) · Acute Pain (2) · Alcoholism (2) · Child Development Disorders, Pervasive (2) · Chronic Pain (2) · Mental Disorders (2) · Obesity (2) · Psychotic Disorders (2) · Substance-Related Disorders (2) · Agnosia (1)
University of Electronic Science and Technology of China (11) · Massachusetts General Hospital (4) · University of California, Los Angeles (4) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (3) · Holland Bloorview Kids Rehabilitation Hospital (2) · Montefiore Medical Center (2) · Shalvata Mental Health Center (2) · University of Minnesota (2) · University of North Carolina, Chapel Hill (2) · Wake Forest University Health Sciences (2) · Alexander Kolevzon (1) · Baylor College of Medicine (1) · David Mankuta (1) · Evdokia Anagnostou (1) · Fundatia Bio-Forum (1)
United States (30) · China (11) · Canada (7) · Israel (3) · Australia (1) · Chile (1) · New Zealand (1) · Romania (1)
Evdokia Anagnostou, M.D. (3) · Gagan Joshi, MD (2) · James C Eisenach, MD (2) · Matthew D Lieberman, PhD (2) · Suma Jacob, M.D., Ph.D. (2) · Yao Shuxia, Dr (2) · Alison M Stuebe, MD, MSc (1) · Ann F Haynos, PhD (1) · Annie Dupuis, Ph.D. (1) · Carol B Peterson, PhD (1) · Christopher Stauffer, MD (1) · Cort A Pedersen, MD (1) · David Mankuta, MD (1) · David Walega, MD (1) · Derek Mitchell, PhD (1)
PMID 37310308, PMID 37811711, PMID 22387929, PMID 25224026, PMID 25462898, PMID 26493637, PMID 27053769, PMID 27314560, PMID 28416501, PMID 30261917, PMID 31128568, PMID 32082606, PMID 32848571, PMID 32963103, PMID 33112417, PMID 33343285, PMID 34029521, PMID 35941573, PMID 36905736, PMID 37171081, PMID 37219072, PMID 37883133, PMID 39862881, PMID 40121179
1IK2CX001495-01 (1), P01NS119159 (1), R01HD093901 (1), R21AA021927 (1), UL1TR000067 (1)