11 completed, 4 unknown, 3 terminated, 2 not yet recruiting. 9 Phase 2, 6 Phase 1, 6 Phase 3, 5 Phase 4, 3 Not applicable.
Follow Intranasal ketamine: new trials by email Literature Review of Intranasal ketamine trials Research Report on Intranasal ketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery. Intranasal dexmedetomidine, Intranasal ketamine - Sedation, Preoperative Anxiety Experienced by the Pediatric Patient | Phase 1 / Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 60 | 2026-01-01 | 2025-09-18 |
| Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain Intranasal Ketorolac Tromethamine, Intranasal ketamine - Pain, Digital Block | Phase 3 | Not yet recruiting | Tehran University of Medical Sciences | 64 | 2025-12-28 | 2025-12-26 |
| Nebulized vs. IV Ketamine in Preventing Shivering Post Spinal Anesthesia Ketamine, Intranasal ketamine, Normal Saline - Post Spinal Anesthesia Shivering | Not applicable | Active not recruiting | Tanta University | 120 | 2025-05-02 | 2025-07-09 |
| INK Feasibility Study Intranasal ketamine - Procedural Sedation | Phase 3 | Withdrawn | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2024-01-01 | 2023-03-24 | |
| IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine - Laceration of Skin, Anxiety | Phase 4 | Recruiting | University of Oklahoma | 90 | 2023-11-14 | 2024-06-28 |
| Intranasal Dexmedetomidine, Ketamine or Midazolam for Anxiety and Respiratory Complications in Children Intranasal Dexmedetomidine as a Premedication for Prevention of Anxiety & Respiratory Complications, Intranasal Ketamine as a Premedication for Prevention of Anxiety and Respiratory Complications, Intranasal Midazolam as a Premedication for Prevention of Anxiety and Respiratory Complications - Adenotonsillectomy | Not applicable | Completed | Zagazig University | 148 | 2023-02-20 | 2025-07-18 |
| Study to Assess the Effects of Intranasal Ketamine Along With rTMS for Patients With Treatment-resistant Major Depressive Disorder (TRD) intranasal ketamine, rTMS treatment - Major Depressive Disorder | Phase 4 | Unknown | University of Cincinnati | 20 | 2020-05-01 | 2020-04-20 |
| Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED Intranasal ketamine - Sickle Cell Disease, Vaso-Occlusive Pain Episode in Sickle Cell Disease | Phase 3 | Terminated | Abigail Nixon | 5 | 2019-12-19 | 2024-11-18 |
| Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures Intravenous Ketamine, Intranasal Ketamine - Trauma, Fractures, Closed | Phase 4 | Terminated | University of Alabama at Birmingham | 40 | 2019-09-09 | 2023-04-20 |
| Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse Intranasal ketamine, Placebo - Suicidal Ideation, Depression | Phase 3 | Completed | The University of Texas Health Science Center, Houston | 33 | 2018-05-01 | 2023-03-01 |
| Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder ketamine and dexmedetomidine, ketamine, Saline - Autism Spectrum Disorder | Phase 2 | Suspended | Guangzhou Women and Children's Medical Center | 50 | 2018-01-20 | 2022-04-12 |
| Intranasal (NAS) Ketamine for Cancer Pain Intranasal ketamine - Cancer, Pain | Phase 1 / Phase 2 | Completed | Emory University | 10 | 2017-07-25 | 2021-09-09 |
| Pain Free Laceration Repairs Using Intra-nasal Ketamine Intranasal Ketamine - Laceration | Phase 2 | Completed | Evelyne D.Trottier | 42 | 2017-02-16 | 2019-12-16 |
| IN Ketamine Vs IN Midazolam and Fentanyl for Abscess I&D intranasal ketamine, intranasal fentanyl, intranasal midazolam - Abscess, Pain | Phase 4 | Completed | University of Tennessee | 19 | 2016-08-01 | 2017-03-27 |
| Emergency Ketamine Treatment of Suicidal Ideation Intranasal Ketamine, Intranasal Saline Placebo - Depression, Suicidal Ideation | Phase 2 / Phase 3 | Unknown | University of Cincinnati | 60 | 2016-08-01 | 2016-08-05 |
| Nasal Ketamine for Minor Procedures in Children Intranasal ketamine, Intranasal atomizer, EMLA - Pain | Not applicable | Unknown | Kaplan Medical Center | 20 | 2016-07-01 | 2016-07-21 |
| Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment Intranasal ketamine, Oral ketamine, Intranasal midazolam - Child Behavior, Dental Caries | Phase 4 | Completed | Universidade Federal de Goias | 84 | 2015-05-21 | 2018-04-30 |
| To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD Ketamine, Midazolam - PTSD | Phase 2 / Phase 3 | Withdrawn | Adriana Feder | 2014-12-01 | 2015-03-25 | |
| Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCD Intranasal Ketamine, Intranasal Midazolam - Obsessive-Compulsive Disorder | Phase 2 | Terminated | New York State Psychiatric Institute | 2 | 2014-09-01 | 2017-05-03 |
| Pre-hospital Care With Intra-Nasal Ketamine for Transport (PRECINKT): A Pilot Study Intranasal Ketamine - Pain, Traumatic Limb Injury | Phase 1 | Completed | University of Calgary | 30 | 2014-03-01 | 2019-09-26 |
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Agnosia (5) · Pain (5) · Depression (2) · Emergencies (2) · Lacerations (2) · Suicidal Ideation (2) · Abscess (1) · Alcoholism (1) · Anemia, Sickle Cell (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Cancer Pain (1) · Child Behavior (1) · Dental Caries (1) · Depressive Disorder, Major (1)
Javelin Pharmaceuticals (4) · University of Cincinnati (2) · Abigail Nixon (1) · Adriana Feder (1) · Emory University (1) · Evelyne D.Trottier (1) · Guangzhou Women and Children's Medical Center (1) · Kaplan Medical Center (1) · Liaquat National Hospital & Medical College (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · New York State Psychiatric Institute (1) · Rhode Island Hospital (1) · Tanta University (1) · Tehran University of Medical Sciences (1) · The University of Texas Health Science Center, Houston (1)
United States (11) · Canada (2) · Egypt (2) · Brazil (1) · China (1)
Adriana Feder, MD (1) · Amira Saeed Kenawy, MD (1) · Carolyn I Rodriguez, M.D., Ph.D. (1) · Cheryl McCullumsmith, MD PhD (1) · Eric Scheier, MD (1) · Evelyne D Trottier, MD, FRCPC (1) · Gary Andolfatto, MD (1) · Hadi Mirfazaelian (1) · James G Linakis, PhD, MD (1) · James Statler, MD (1) · Judson Barber, MD (1) · Kyle Christensen, DDS (1) · Luciane R Costa, DDS, MS, PhD (1) · Qing Zhao, Doctor (1)
PMID 23365053, PMID 24127709, PMID 24987995, PMID 28399933, PMID 30856181, PMID 33583341, PMID 34928491, PMID 36774905, PMID 38696221
2019 (1)