15 completed, 5 unknown, 3 not yet recruiting, 3 recruiting. 8 Phase 4, 6 Not applicable, 5 Phase 3, 4 Phase 2, 3 Phase 1.
Follow Intranasal dexmedetomidine: new trials by email Literature Review of Intranasal dexmedetomidine trials Research Report on Intranasal dexmedetomidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Dexmedetomidine and Perioperative Myocardial Injury in Patients Having Percutaneous Coronary Interventions Intranasal dexmedetomidine, Normal Saline - Coronary Heart Disease, Coronary Artery Disease | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2500 | 2026-09-30 | 2026-09-29 |
| Intranasal Dexmedetomidine and Perioperative Myocardial Injury Intranasal Dexmedetomidine, Normal saline - Coronary Heart Disease, Myocardial Injury | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 140 | 2026-08-01 | 2026-07-30 |
| The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder Intranasal dexmedetomidine, Intranasal Esketamine, saline control - Autism Spectrum Disorder | Not applicable | Recruiting | Sun Fei | 234 | 2026-04-01 | 2026-04-15 |
| Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery. Intranasal dexmedetomidine, Intranasal ketamine - Sedation, Preoperative Anxiety Experienced by the Pediatric Patient | Phase 1 / Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 60 | 2026-01-01 | 2025-09-18 |
| Intranasal Dexmedetomidine on Blood Pressure in Elderly Hypertensive Patients Undergoing Cataract Surgery Intranasal dexmedetomidine, Intranasal normal saline - Cataract, Hypertension | Phase 3 | Recruiting | Suez Canal University | 126 | 2025-07-16 | 2026-04-07 |
| Comparison of Intranasal Dexmedetomidine and Short Video Viewing in the Preoperative Anxiety Intranasal dexmedetomidine - Anesthesia, Sedation | Completed | Samsun University | 50 | 2025-07-01 | 2025-11-24 | |
| Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft. intranasal saline group, intranasal insulin, Intranasal dexmedetomidine - Post Operative Cognitive Dysfunction | Early Phase 1 | Completed | Minia University | 150 | 2024-12-27 | 2026-10-28 |
| Effectiveness of Intranasal Dexmedetomidine Premedication in Child Intubation Intranasal dexmedetomidine, 0.9% NaCl solution - Elective Surgical Procedure, ASA Physical Status I | Phase 3 | Completed | Universitas Indonesia | 40 | 2024-10-28 | 2025-05-28 |
| IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine - Laceration of Skin, Anxiety | Phase 4 | Recruiting | University of Oklahoma | 90 | 2023-11-14 | 2024-06-28 |
| Intranasal Dexmedetomidine, Ketamine or Midazolam for Anxiety and Respiratory Complications in Children Intranasal Dexmedetomidine as a Premedication for Prevention of Anxiety & Respiratory Complications, Intranasal Ketamine as a Premedication for Prevention of Anxiety and Respiratory Complications, Intranasal Midazolam as a Premedication for Prevention of Anxiety and Respiratory Complications - Adenotonsillectomy | Not applicable | Completed | Zagazig University | 148 | 2023-02-20 | 2025-07-18 |
| Intranasal Dexmedetomidine Versus Intravenous Dexmedetomidine for Improving Quality of Endoscopic Sinus Surgery intranasal dexmedetomidine, intravenous dexmedetomidine - Dexmedetomidine, Functional Endoscopic Sinus | Phase 4 | Unknown | Kafrelsheikh University | 54 | 2022-12-20 | 2023-10-13 |
| Intranasal Versus Intravenous Dexmedetomidine for Hypotensive Anesthesia in FESS Intranasal dexmedetomidine, Intravenous dexmedetomidine - Functional Endoscopic Sinus Surgery, Premedication | Phase 4 | Completed | Al-Azhar University | 60 | 2022-11-10 | 2023-03-14 |
| Intranasal Versus Intravenous Drug in Painful Procedure for Outpatient Oncologic Participants intranasal dexmedetomidine, intranasal fentanyl, intravenous ketamine (ketalar®) - Pediatric Cancer, Analgesia | Phase 3 | Unknown | University of Sao Paulo General Hospital | 60 | 2021-06-01 | 2021-04-01 |
| Combination With Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Patients Midazolam, Dexmedetomidine, Midazolam and Dexmedetomidine - Anxiety | Phase 4 | Unknown | Second Affiliated Hospital of Wenzhou Medical University | 138 | 2019-10-25 | 2019-11-05 |
| Sublingual Versus Intranasal Administration of Dexmedetomidine for Sedation of Children Undergoing Dental Treatment Intranasal Dexmedetomidine, Sublingual Dexmedetomidine - Anti-anxiety Agents, Moderate Sedation | Phase 2 / Phase 3 | Completed | Nourhan M.Aly | 42 | 2019-08-27 | 2020-10-29 |
| ED50 and ED95 of Intranasal Dexmedetomidine in Pediatric Patients Undergoing Transthoracic Echocardiography Study intranasal dexmedetomidine - Patients for Transthoracic Echocardiography, Unknown Diagnosis | Phase 4 | Completed | Guangzhou Women and Children's Medical Center | 320 | 2019-08-10 | 2022-10-10 |
| Intranasal Dexmedetomidine Versus Intranasal Midazolam for Emergence Delirium Prevention Intranasal dexmedetomidine, Intranasal Midazolam - Emergence Delirium | Phase 4 | Completed | Universitas Indonesia | 66 | 2019-01-10 | 2020-02-12 |
| Intranasal Dexmedetomidine Sedation in Children for Non-painful Procedures Intranasal dexmedetomidine - Dexmedetomidine, Sedation | Completed | Columbia University | 578 | 2018-09-04 | 2021-09-10 | |
| Procedure Sedation With Dexmedetomidine in Children With Autism Spectrum Disorders During Magnetic Resonance Imaging Dexmedetomidine - Autism Spectrum Disorder | Completed | Guangzhou Women and Children's Medical Center | 136 | 2018-07-16 | 2021-02-25 | |
| Sublingual Ketorolac Compared to Intranasal Dexmedetomidine for Postoperative Analgesia in Pediatric Patients Undergoing Bilateral Myringotomy intranasal dexmedetomidine, sublingual ketorolac - Elective Bilateral Myringotomy | Not applicable | Withdrawn | Mansoura University | 2018-01-01 | 2020-09-09 |
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Agnosia (5) · Anxiety Disorders (3) · Pain (3) · Autism Spectrum Disorder (2) · Bunion (2) · Coronary Disease (2) · Pain, Postoperative (2) · Cataract (1) · Coronary Artery Disease (1) · Delirium (1) · Emergence Delirium (1) · Hypertension (1) · Myocardial Infarction (1) · Neoplasms (1) · Pain, Procedural (1)
Guangzhou Women and Children's Medical Center (3) · Baudax Bio (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · Universitas Indonesia (2) · Al-Azhar University (1) · Columbia University (1) · Guangzhou First People's Hospital (1) · Jiangsu HengRui Medicine Co., Ltd. (1) · Kafrelsheikh University (1) · Liaquat National Hospital & Medical College (1) · Mansoura University (1) · Minia University (1) · Nourhan M.Aly (1) · Samsun University (1) · Second Affiliated Hospital of Wenzhou Medical University (1)
China (10) · Egypt (7) · United States (4) · Indonesia (2) · Brazil (1) · Finland (1) · Hong Kong (1) · Turkey (Türkiye) (1)
Neil Singla, MD (2) · Ahmed M El-Shafei, PhD (1) · Amira Saeed Kenawy, MD (1) · Andi Ade W Ramlan (1) · Caner Genc, M.D. (1) · Dalia M Talaat, PhD (1) · Daniel S Tsze, MD, MPH (1) · Haotian Lin, Ph.D. (1) · Huacheng Liu (1) · Kamal Ebeid, MD (1) · Klaus T Olkkola, MD, PhD, Professor (1) · May Shaat, BDS (1) · Niveen Bakry, PhD (1) · Ryan Mckee, MD (1) · Timo Iirola, MD (1)
PMID 18372935, PMID 20740210, PMID 21309294, PMID 21318594, PMID 21390159, PMID 2301747, PMID 24447296, PMID 25085962, PMID 25535538, PMID 27196121, PMID 27229908, PMID 27627818, PMID 29661413, PMID 31114165, PMID 31668347, PMID 34397100, PMID 34838503, PMID 36369026, PMID 36810939