16 completed, 5 terminated, 2 recruiting, 1 active not recruiting. 25 Phase 2, 9 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 25 | Completed 16, Terminated 5, Recruiting 2, Active not recruiting 1, Unknown 1 |
| Phase 1 | 9 | Completed 5, Terminated 4 |
| Phase 3 | 1 | Completed 1 |
Follow interferon gamma-1b: new trials by email Literature Review of interferon gamma-1b trials Research Report on interferon gamma-1b
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial Tocilizumab, Baricitinib, Anakinra - Sepsis | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2000 | 2026-07-09 | 2026-10-20 |
| Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation Interferon gamma-1b, Donor Leukocyte Infusion (DLI) - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 2 | Recruiting | Sawa Ito, MD | 57 | 2024-09-23 | 2026-08-11 |
| Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study Interferon Gamma-1B 0.1 MG Per 0.5 ML Injection PLUS antifungals as standard of care, Antifungals as standard of care - Chronic Pulmonary Aspergillosis, Aspergillosis | Phase 2 | Active not recruiting | Manchester University NHS Foundation Trust | 50 | 2024-05-17 | 2026-08-18 |
| Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia Interferon Gamma-1B - Candidemia | Phase 2 | Completed | Radboud University Medical Center | 65 | 2022-03-31 | 2026-06-22 |
| Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR, Avelumab, Pembrolizumab - Other Skin | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 7 | 2019-07-03 | 2025-03-06 |
| Testing the Combination of Two Experimental Drugs MK-3475 (Pembrolizumab) and Interferon-gamma for the Treatment of Mycosis Fungoides and Sézary Syndrome and Advanced Synovial Sarcoma Interferon Gamma-1b, Laboratory Biomarker Analysis, Pembrolizumab - Metastatic Myxoid Liposarcoma, Metastatic Round Cell Liposarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 28 | 2017-12-14 | 2023-10-25 |
| Phase I-II Study of Interferon-gamma in Patients With HER-2 Positive Breast Cancer Interferon-gamma (IFN-γ), Paclitaxel, Trastuzumab - Breast Cancer, Breast Cancer, Male | Phase 1 / Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 51 | 2017-06-23 | 2023-04-19 |
| ACTIMMUNE in Intermediate Osteopetrosis Interferon gamma-1b - Osteopetrosis | Phase 2 | Completed | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 5 | 2016-02-22 | 2024-10-22 |
| Use of ACTIMMUNE in Patients With ADO2 ACTIMMUNE - Autosomal Dominant Osteopetrosis Type 2 | Phase 2 | Completed | Indiana University | 12 | 2016-01-01 | 2021-01-08 |
| Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS) Interferon gamma-1b - Inherited Ophthalmic Diseases, Inherited Retinal Degeneration | Phase 1 / Phase 2 | Terminated | National Eye Institute (NEI) | 4 | 2015-01-14 | 2019-08-13 |
| Interferon Gamma-1b in Friedreich Ataxia (FRDA) Interferon Gamma-1b - Friedreich Ataxia | Phase 2 | Completed | Children's Hospital of Philadelphia | 12 | 2013-08-01 | 2021-04-13 |
| Topical Interferon Gamma-1b for Central Serous Chorioretinopathy Interferon gamma-1b - Retinal Disease, Macular Disease | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2011-10-01 | 2024-01-30 |
| Topical Interferon Gamma for Macular Edema Secondary to Uveitis Interferon Gamma-1b - Anterior Uveitis, Uveitis | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2011-06-01 | 2012-10-08 |
| A Phase II Study to Determine the Safety and Efficacy of Interferon-gamma in Patients With Chronic Hepatitis B IFN-γ 1b (Actimmune), Adefovir dipivoxil, IFN-γ 1b and Adefovir dipivoxil combination - Hepatitis B | Phase 2 | Unknown | Huntington Medical Research Institutes | 30 | 2008-09-01 | 2010-10-21 |
| Study of Gamma Interfereon in Metastatic Colorectal Carcinoma 5-Fluorouracil, Leucovorin (LV), Gamma-Interferon-1b (IFN-γ) - Colorectal Cancer | Phase 2 | Completed | Accelerated Community Oncology Research Network | 48 | 2006-02-01 | 2012-03-01 |
| CIFN and IFN γ-1b With or Without Ribavirin for Treatment of Chronic Hepatitis C (Nonresponders) Consensus Interferon-Alpha, Interferon Gamma-1b, Ribavirin - Chronic Hepatitis C | Phase 2 | Completed | InterMune | 81 | 2004-04-01 | 2009-07-03 |
| Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma aldesleukin, filgrastim, recombinant interferon gamma - Lymphoma | Phase 2 / Phase 3 | Completed | Children's Oncology Group | 24 | 2003-11-01 | 2013-10-17 |
| Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients Interferon Gamma-1b, Rituximab - Non-Hodgkin's Lymphoma | Phase 1 / Phase 2 | Terminated | InterMune | 24 | 2003-03-01 | 2007-11-01 |
| Study of Interferon Gamma-1b by Injection for the Treatment of Patients With Cystic Fibrosis interferon gamma-1b - Cystic Fibrosis | Phase 1 / Phase 2 | Completed | InterMune | 51 | 2002-04-01 | 2007-11-01 |
| Safety and Efficacy Study of Interferon Gamma-1b in Hepatitis C Patients With Liver Fibrosis or Cirrhosis interferon gamma-1b - Liver Fibrosis, Cirrhosis | Phase 2 | Completed | InterMune | 502 | 2001-09-01 | 2007-11-01 |
Showing 20 of 25. Sign in to see all of them.
Cystic Fibrosis (2) · HIV Infections (2) · Lymphoma (2) · Macular Edema (2) · Osteopetrosis (2) · AIDS-Related Complex (1) · Acquired Immunodeficiency Syndrome (1) · Aspergillosis (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Candidemia (1) · Carcinoma, Merkel Cell (1) · Central Serous Chorioretinopathy (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1)
InterMune (7) · National Eye Institute (NEI) (3) · National Cancer Institute (NCI) (2) · Accelerated Community Oncology Research Network (1) · Assistance Publique - Hôpitaux de Paris (1) · Children's Hospital of Philadelphia (1) · Children's Oncology Group (1) · Fred Hutchinson Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Huntington Medical Research Institutes (1) · Indiana University (1) · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (1) · Manchester University NHS Foundation Trust (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Radboud University Medical Center (1)
United States (20) · Australia (1) · Canada (1) · France (1) · Germany (1) · Greece (1) · Netherlands (1) · Peru (1) · Romania (1) · Switzerland (1) · United Kingdom (1)
Steven Porter, MD (3) · Allen R. Chen, MD, PhD, MHS (1) · Chris Kosmidis, MD (1) · Corey L (1) · David Lynch, MD, PhD (1) · Emily Y Chew, M.D. (1) · Hatice Nida Sen, MD, MHSc (1) · Joshua Veatch (1) · Kaplan L (1) · Lee Schwartzberg, MD (1) · Lynda E Polgreen, MD, MS (1) · Matthew McClure, MD (1) · Max Sung (1)
PMID 15940636, PMID 15994231, PMID 16912304, PMID 17030856, PMID 2106474, PMID 2452123, PMID 30889272, PMID 3129521, PMID 32269142, PMID 34056870, PMID 35880940, PMID 42715345
P01CA225517 (1), P30CA015704 (1), U01CA154967 (1)