10 completed, 5 terminated, 1 unknown. 16 Phase 1, 9 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 10, Terminated 5, Unknown 1 |
| Phase 2 | 9 | Completed 5, Terminated 4 |
Follow interferon gamma-1b: new trials by email Literature Review of interferon gamma-1b trials Research Report on interferon gamma-1b
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gene-Modified Immune Cells (FH-MCVA2TCR) in Treating Patients With Metastatic or Unresectable Merkel Cell Cancer Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR, Avelumab, Pembrolizumab - Other Skin | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 7 | 2019-07-03 | 2025-03-06 |
| Phase I-II Study of Interferon-gamma in Patients With HER-2 Positive Breast Cancer Interferon-gamma (IFN-γ), Paclitaxel, Trastuzumab - Breast Cancer, Breast Cancer, Male | Phase 1 / Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 51 | 2017-06-23 | 2023-04-19 |
| Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer Autologous Monocytes + ACTIMMUNE + SYLATRON - Fallopian Tube Cancer, Ovarian Cancer | Phase 1 | Terminated | National Cancer Institute (NCI) | 18 | 2017-02-08 | 2026-01-08 |
| Effect of IFN-γ on Innate Immune Cells Administration of drug (Interferon-gamma 1-b) subcutaneously - Chronic Granulomatous Disease | Phase 1 | Completed | University of Colorado, Denver | 20 | 2016-07-01 | 2019-02-15 |
| Interferon Gamma-1b Administered Topically for Macular Edema/Intraretinal Schisis Cysts in Rod-Cone Dystrophy (RCD) and Enhanced S-Cone Syndrome (ESCS) Interferon gamma-1b - Inherited Ophthalmic Diseases, Inherited Retinal Degeneration | Phase 1 / Phase 2 | Terminated | National Eye Institute (NEI) | 4 | 2015-01-14 | 2019-08-13 |
| DNX-2401 With Interferon Gamma (IFN-γ) for Recurrent Glioblastoma or Gliosarcoma Brain Tumors Single intratumoral injection of DNX-2401, Interferon-gamma - Glioblastoma or Gliosarcoma | Phase 1 | Completed | DNAtrix, Inc. | 37 | 2014-09-11 | 2018-07-16 |
| Determining the Effect of Actimmune (Interferon Gamma 1b)Dose Titration on Flu-Like Symptoms in Healthy Volunteers interferon gamma 1b - Adverse Effects in the Therapeutic Use of Interferon | Phase 1 | Unknown | Vidara Therapeutics Research Ltd | 40 | 2013-07-01 | 2013-08-28 |
| Topical Interferon Gamma-1b for Central Serous Chorioretinopathy Interferon gamma-1b - Retinal Disease, Macular Disease | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2011-10-01 | 2024-01-30 |
| Topical Interferon Gamma for Macular Edema Secondary to Uveitis Interferon Gamma-1b - Anterior Uveitis, Uveitis | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 5 | 2011-06-01 | 2012-10-08 |
| Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients Interferon Gamma-1b, Rituximab - Non-Hodgkin's Lymphoma | Phase 1 / Phase 2 | Terminated | InterMune | 24 | 2003-03-01 | 2007-11-01 |
| Study of Interferon Gamma-1b by Injection for the Treatment of Patients With Cystic Fibrosis interferon gamma-1b - Cystic Fibrosis | Phase 1 / Phase 2 | Completed | InterMune | 51 | 2002-04-01 | 2007-11-01 |
| Interferon Gamma-1b by Inhalation for the Treatment of Patients With Cystic Fibrosis interferon gamma-1b - Cystic Fibrosis | Phase 1 / Phase 2 | Completed | InterMune | 66 | 2001-02-01 | 2007-11-01 |
| Tumor Vaccine and Interferon Gamma in Treating Patients With Refractory Epithelial Ovarian Cancer ALVAC-hB7.1, recombinant interferon gamma, laboratory biomarker analysis - Recurrent Ovarian Epithelial Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 1997-10-01 | 2013-01-23 |
| Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer fluorouracil, sodium phenylbutyrate, indomethacin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 46 | 1997-05-01 | 2013-02-01 |
| The Safety and Effectiveness of Injections of Human Recombinant Interferon-gamma in Patients With AIDS Who Have Taken Zidovudine Zidovudine, Interferon gamma-1b - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5 | 2021-11-04 | |
| Phase I/II Study of Recombinant Human Interferon-gamma (rIFN-gamma) in HIV-Infected Children Interferon gamma-1b - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 20 | 2021-11-03 |
Acquired Immunodeficiency Syndrome (2) · Cystic Fibrosis (2) · HIV Infections (2) · Macular Edema (2) · AIDS-Related Complex (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma (1) · Carcinoma, Merkel Cell (1) · Carcinoma, Ovarian Epithelial (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Central Serous Chorioretinopathy (1) · Colonic Neoplasms (1)
InterMune (3) · National Cancer Institute (NCI) (3) · National Eye Institute (NEI) (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · DNAtrix, Inc. (1) · Fred Hutchinson Cancer Center (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · University of Colorado, Denver (1) · Vidara Therapeutics Research Ltd (1)
United States (15)
Daniel R. Ambruso, MD (1) · Emily Y Chew, M.D. (1) · Frederick Lang, MD (1) · HW Murray (1) · Hatice Nida Sen, MD, MHSc (1) · Joshua Veatch (1) · Karen Fink, MD, PhD (1) · MW Kline (1) · Mark Matson, MD (1) · Max Sung (1) · Nam Tran, MD, PhD (1) · Ralph Freedman (1) · SL Abramson (1) · Stanley Lipkowitz, M.D. (1)
PMID 24576196, PMID 33278077, PMID 35113934, PMID 35880940, PMID 42715345
P01CA225517 (1), U01CA062461 (1), UL1TR001082 (1)