16 completed, 8 active not recruiting, 4 recruiting, 3 terminated. 34 Phase 1, 11 Phase 2.
Follow Intensity-modulated radiotherapy: new trials by email Literature Review of Intensity-modulated radiotherapy trials Research Report on Intensity-modulated radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma Biospecimen Collection, Computed Tomography, Intensity-Modulated Radiation Therapy - Astrocytoma, IDH-Mutant, Grade 2, Recurrent Adult Diffuse Hemispheric Glioma, H3 G34-Mutant | Phase 1 | Recruiting | National Cancer Institute (NCI) | 30 | 2025-07-30 | 2026-10-21 |
| Radiotherapy with Immunotherapy and Anti-Angiogenic Therapy for Advanced HER2-Negative Breast Cancer: a Single-Arm Study Intensity-modulated radiotherapy, Immunotherapy Therapy - Breast Cancer, Metastatic Breast Cancer | Phase 1 / Phase 2 | Enrolling by invitation | Zhongnan Hospital | 25 | 2024-08-08 | 2025-03-24 |
| Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma Biopsy, Biospecimen Collection, Computed Tomography - Retroperitoneal Sarcoma | Phase 1 / Phase 2 | Recruiting | Northwestern University | 28 | 2024-04-02 | 2026-07-07 |
| TMLI and Alemtuzumab for Treatment of Sickle Cell Disease Alemtuzumab, Hematopoietic Cell Transplantation, Intensity-Modulated Radiation Therapy - Sickle Cell Disease | Phase 1 | Active not recruiting | City of Hope Medical Center | 20 | 2022-07-13 | 2026-07-30 |
| Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin Intensity-Modulated Radiation Therapy, Peposertib - Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2021-12-20 | 2026-10-13 |
| Partial Brain RT, Temozolomide, Chloroquine, and TTF Therapy for the Treatment of Newly Diagnosed Glioblastoma 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Temozolomide - Glioblastoma, Gliosarcoma | Phase 1 | Terminated | Barbara Ann Karmanos Cancer Institute | 2 | 2021-08-12 | 2025-01-15 |
| Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer Capecitabine, Fluorouracil, Intensity-Modulated Radiation Therapy - Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 25 | 2021-02-11 | 2026-03-30 |
| NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer Capecitabine, Carboplatin, Docetaxel - Cervical Esophagus Adenocarcinoma, Clinical Stage II Esophageal Adenocarcinoma AJCC v8 | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 24 | 2020-11-23 | 2026-10-07 |
| Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer Dabrafenib, Intensity-Modulated Radiation Therapy, Trametinib - BRAF NP_004324.2:p.V600E, BRAF V600K Mutation Present | Phase 1 | Suspended | City of Hope Medical Center | 6 | 2020-09-14 | 2026-10-15 |
| TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT Hematopoietic Cell Transplantation, Intensity-Modulated Radiation Therapy, Tomotherapy - Acute Leukemia, Myelodysplastic Syndrome | Phase 1 | Active not recruiting | City of Hope Medical Center | 20 | 2020-02-28 | 2026-08-05 |
| TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Trifluridine and Tipiracil Hydrochloride - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 1 | Completed | OHSU Knight Cancer Institute | 19 | 2019-12-11 | 2026-08-06 |
| Testing the Addition of a New Anti-Cancer Drug, Niraparib, to the Usual Treatment (Hormone and Radiation Therapy) for Prostate Cancer With a High Chance of Recurring Gonadotrophin Releasing Hormone, Intensity-Modulated Radiation Therapy, Niraparib - Prostate Adenocarcinoma, Stage IIC Prostate Cancer AJCC v8 | Phase 1 / Phase 2 | Completed | NRG Oncology | 22 | 2019-10-08 | 2026-07-10 |
| Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma Biopsy Procedure, Birinapant, Computed Tomography - Locally Recurrent Head and Neck Squamous Cell Carcinoma, Nasopharyngeal Squamous Cell Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 13 | 2019-09-25 | 2026-08-03 |
| Triapine With Chemotherapy and Radiation Therapy in Treating Patients With IB2-IVA Cervical or Vaginal Cancer Biospecimen Collection, Brachytherapy, Cisplatin - Advanced Cervical Adenocarcinoma, Advanced Cervical Adenosquamous Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 21 | 2019-09-18 | 2026-10-30 |
| Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery Eribulin Mesylate, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Liposarcoma, Malignant Abdominal Neoplasm | Phase 1 | Active not recruiting | OHSU Knight Cancer Institute | 15 | 2018-03-19 | 2026-04-08 |
| Pembrolizumab, Paclitaxel, Carboplatin, and Radiation Therapy in Treating Patients With Stage II-IIIB Non-Small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Carboplatin, Intensity-Modulated Radiation Therapy - Stage II Non-Small Cell Lung Cancer, Stage IIIA Non-Small Cell Lung Cancer | Phase 1 | Completed | Rutgers, The State University of New Jersey | 23 | 2016-08-04 | 2025-12-16 |
| Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis, Pharmacological Study - Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 19 | 2016-02-01 | 2026-09-15 |
| Onalespib in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin Cisplatin, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7, Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7 | Phase 1 | Completed | National Cancer Institute (NCI) | 2 | 2015-10-22 | 2025-02-11 |
| Methoxyamine Hydrochloride, Pemetrexed Disodium, Cisplatin, and Radiation Therapy in Treating Patients With Stage IIIA-IV Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Cisplatin, Intensity-Modulated Radiation Therapy - Locally Advanced Lung Non-Squamous Non-Small Cell Carcinoma, Stage III Lung Adenocarcinoma AJCC v7 | Phase 1 | Completed | National Cancer Institute (NCI) | 17 | 2015-09-30 | 2022-06-30 |
| Pembrolizumab and Stereotactic Body Radiation Therapy or Non-Stereotactic Wide-Field Radiation Therapy in Treating Patients With Non-small Cell Lung Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Malignant Solid Neoplasm, Metastatic Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Completed | M.D. Anderson Cancer Center | 124 | 2015-09-17 | 2026-05-15 |
Showing 20 of 34. Sign in to see all of them.
Glioblastoma (6) · Gliosarcoma (6) · Astrocytoma (4) · Carcinoma, Non-Small-Cell Lung (4) · Rectal Neoplasms (3) · Nasopharyngeal Carcinoma (2) · Squamous Cell Carcinoma of Head and Neck (2) · Adenocarcinoma of Lung (1) · Anemia, Sickle Cell (1) · Breast Neoplasms (1) · Carcinoma (1) · Choroid Plexus Neoplasms (1) · Colonic Neoplasms (1) · Craniopharyngioma (1) · Diffuse Intrinsic Pontine Glioma (1)
National Cancer Institute (NCI) (13) · City of Hope Medical Center (3) · M.D. Anderson Cancer Center (3) · OHSU Knight Cancer Institute (2) · Barbara Ann Karmanos Cancer Institute (1) · Children's Oncology Group (1) · Fred Hutchinson Cancer Center (1) · Jiangsu Cancer Institute & Hospital (1) · Jonsson Comprehensive Cancer Center (1) · NRG Oncology (1) · Northwestern University (1) · Rutgers, The State University of New Jersey (1) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (1) · Taizhou Hospital (1) · University of Chicago (1)
United States (30) · China (4) · Canada (3) · Australia (1)
Steven H Lin (2) · Andrew J Hope (1) · Andrew Poklepovic, MD (1) · Ann Raldow (1) · Anna Pawlowska (1) · Antonio Omuro (1) · Brian D Weiss (1) · Chao Zhou, MD. (1) · Charles D Lopez, MD, PhD (1) · Elizabeth R Gerstner, MD (1) · Guopei Zhu (1) · Haihua Yang, MD. (1) · Hans-Peter Kiem (1) · Hongtao Liu (1) · Jack M Su (1)
PMID 24309981, PMID 25105369, PMID 25113840, PMID 31996395, PMID 32009149, PMID 32077891, PMID 32504550, PMID 32827353, PMID 33051340, PMID 33096027, PMID 33571520, PMID 33842889, PMID 34028986, PMID 34749885, PMID 35091445, PMID 38197800, PMID 39673591, PMID 39863139, PMID 41781240, PMID 42501677
U10CA098543 (2), U10CA180868 (2), U10CA180886 (2), P01CA021239 (1), P30CA006516 (1), P30CA008748 (1), P30CA014599 (1), P30CA016059 (1), P30CA016672 (1), P30CA033572 (1), P30CA043703 (1), P30CA047904 (1), P30CA060553 (1), P30CA072720 (1), P50CA070907 (1)