9 completed, 5 unknown, 1 active not recruiting, 1 not yet recruiting. 15 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 7, Unknown 4, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow High flow nasal oxygen: new trials by email Literature Review of High flow nasal oxygen trials Research Report on High flow nasal oxygen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative High-flow Nasal Oxygen in Patients Undergoing Robotic Surgery High flow nasal oxygen - Robotic Surgery | Not applicable | Not yet recruiting | Beth Israel Deaconess Medical Center | 190 | 2026-11-01 | 2026-10-26 |
| WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen - Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Not applicable | Recruiting | Ohio State University | 500 | 2026-08-18 | 2026-10-01 |
| High Flow Nasal Oxygen Cannula in Transcatheter Aortic Valve Replacement: Complications and Biomarkers High flow nasal oxygen - Aortic Stenosis, Sedation Complication | Not applicable | Completed | Hospital Clinic of Barcelona | 132 | 2023-11-01 | 2024-12-19 |
| Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study. HIGH FLOW NASAL OXYGEN - Acute Respiratory Failure, High Flow Nasal Cannula | Unknown | Azienda Sanitaria-Universitaria Integrata di Udine | 20 | 2023-04-01 | 2023-01-31 | |
| High-flow Nasal Cannula for Pediatric Anesthetic Induction high flow nasal oxygen, face mask - Oxygen Deficiency | Not applicable | Completed | Seoul National University Hospital | 132 | 2022-10-21 | 2025-06-18 |
| Ventilatory Effects of THRIVE During EBUS THRIVE (High Flow Nasal Cannula) - Hypercapnia, Sedation Complication | Phase 3 | Completed | Rijnstate Hospital | 20 | 2022-10-05 | 2024-08-15 |
| Effect of HFNO Therapy on Respiratory Effort After Extubation High Flow Nasal Oxygen, Conventional Oxygen Therapy - Respiratory Failure, Post Extubation Acute Respiratory Failure Requiring Reintubation | Not applicable | Completed | Henrik Endeman | 42 | 2022-10-01 | 2025-01-17 |
| HFNO VERSUS BIPAP IN PREECLAMPTIC PATIENTS WITH ACUTE HYPOXAEMIC RESPIRATORY FAILURE High flow nasal oxygen, non invasive BIPAP - HFNO vs BIPAP, Preeclamptic Acute Hypoxaemic Respiratory Failure | Not applicable | Completed | Alexandria University | 60 | 2022-04-01 | 2025-07-29 |
| HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT Helmet Non-Invasive Ventilation (HNIV), High Flow Nasal Oxygen - Acute Hypoxemic Respiratory Failure | Not applicable | Active not recruiting | Sunnybrook Health Sciences Centre | 200 | 2022-03-17 | 2026-03-16 |
| HFNC Vs LFNC in Patients with AF Undergoing RFCA Under Deep Sedation. High flow nasal cannula - Deep Sedation, Oxygen Therapy | Not applicable | Terminated | Maastricht University Medical Center | 141 | 2022-01-04 | 2025-02-20 |
| HFNO or Conventional Oxygen Therapy for Patients With Acute Hypoxemic Respiratory Distress High Flow Nasal Oxygen - Acute Hypoxemic Respiratory Distress | Not applicable | Unknown | Centre Hospitalier Universitaire de Besancon | 500 | 2020-11-23 | 2024-06-24 |
| High-flow Nasal Oxygen Therapy to Prevent Extubation Failure in Adult Trauma Intensive Care Patients High flow nasal oxygen - Intensive Care, Airway Extubation | Not applicable | Unknown | Hamad Medical Corporation | 450 | 2020-10-17 | 2023-10-31 |
| High Flow Nasal Oxygen During Sedation High flow nasal oxygen, Standard oxygenation - Anesthesia, Cardiac Disease | Not applicable | Completed | University Health Network, Toronto | 129 | 2019-08-07 | 2020-11-12 |
| High Flow Nasal Oxygen Versus Usual Care in COPD Pulmonary Rehabiliation Usual care, High flow nasal oxygen - Chronic Obstructive Pulmonary Disease | Not applicable | Unknown | Changi General Hospital | 22 | 2019-05-28 | 2020-10-08 |
| A Pilot Study Comparing Oxygen Delivery Via Helmet Interface Versus High Flow Nasal Cannula Helmet, High Flow Nasal Oxygen - Hypoxemic Respiratory Failure | Not applicable | Unknown | Baystate Medical Center | 1 | 2018-06-01 | 2021-07-22 |
| High Flow Nasal Oxygen and Acute Left Heart Failure High Flow Nasal Oxygen, Non-invasive Ventilation - Heart Failure, Noninvasive Ventilation | Not applicable | Completed | Nanjing Jiangbei People's Hospital | 123 | 2018-05-10 | 2022-04-14 |
| Assessment of High Flow Nasal Cannula Oxygenation in EBUS Bronchoscopy high flow nasal oxygen - Lung Cancer, Lymphadenopathy | Not applicable | Completed | University College Hospital Galway | 40 | 2016-10-01 | 2018-05-02 |
| High Flow Nasal Cannula Therapy for Early Management of Acute Hypercapnic Cardiogenic Pulmonary Edema in the Emergency Department High flow nasal therapy (HFNT) : Optiflow™, Non invasive ventilation (niv) - Acute Cardiogenic Pulmonary Edema, Hypercapnic Respiratory Failure | Completed | University Hospital, Montpellier | 32 | 2015-02-01 | 2019-03-25 |
Respiratory Insufficiency (7) · Hypercapnia (3) · Pulmonary Disease, Chronic Obstructive (2) · Aortic Valve Stenosis (1) · Critical Illness (1) · Emergencies (1) · Heart Diseases (1) · Heart Failure (1) · Hypoxia (1) · Lung Neoplasms (1) · Lymphadenopathy (1) · Respiratory Aspiration (1) · Respiratory Distress Syndrome (1)
Alexandria University (1) · Azienda Sanitaria-Universitaria Integrata di Udine (1) · Baystate Medical Center (1) · Beth Israel Deaconess Medical Center (1) · Centre Hospitalier Universitaire de Besancon (1) · Changi General Hospital (1) · Hamad Medical Corporation (1) · Henrik Endeman (1) · Hospital Clinic of Barcelona (1) · Maastricht University Medical Center (1) · Nanjing Jiangbei People's Hospital (1) · Ohio State University (1) · Rijnstate Hospital (1) · Seoul National University Hospital (1) · Sunnybrook Health Sciences Centre (1)
Netherlands (3) · United States (3) · Canada (2) · France (2) · China (1) · Egypt (1) · Ireland (1) · Italy (1) · Qatar (1) · Singapore (1) · South Korea (1) · Spain (1)
Aaron Conway, RN, PhD (1) · Cristian Deana, MD (1) · Damon Scales, MD PhD FRCPC (1) · David Breen (1) · Esther AC Bouman, Doctor (1) · Eun-hee Kim (1) · Henry E Wang, MD, MS (1) · Jarrod Mosier, MD (1) · Jeffrey Miechels (1) · Lai Wei, PhD (1) · Mark A Tidswell, MD (1) · Mark Tidswell, MD (1) · Mark V Koning, MD, PhD (1) · Mustapha Sebbane, MD, PhD (1) · Niall Fergusson, MD FRCPC (1)
PMID 32291308, PMID 33492872, PMID 35534903, PMID 39160110, PMID 41145249, PMID 41395998, PMID 41557566
U24HL175258 (1), UG3HL175260 (1)