37 completed, 12 unknown, 4 terminated, 3 recruiting. 60 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 60 | Completed 37, Unknown 12, Terminated 4, Recruiting 3, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1 |
Follow Folic Acid: new trials by email Literature Review of Folic Acid trials Research Report on Folic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia methotrexate, rituximab, bortezomib - Hypophosphatasia | Phase 4 | Withdrawn | Alexion Pharmaceuticals, Inc. | 2026-07-29 | 2025-12-18 | |
| Comparing Effectiveness of Steroids and Methotrexate in Treatment of Chronic Inflammatory Breast Disease Prednisolone, Methotrexate, Folic Acid 5 MG - Idiopathic Granulomatous Mastitis | Phase 4 | Not yet recruiting | National University Hospital, Singapore | 40 | 2025-07-01 | 2025-04-24 |
| Myo-Inositol and D-Chiro-Inositol for Menstrual Irregularities and Hormone Changes in Women With Polycystic Ovarian Syndrome Myo-Inositol and D-Chiro-Inositol Combination Therapy, placebo (folic acid) - Polycystic Ovary Syndrome (PCOS), Myo-inositol | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-06-01 | 2026-07-14 |
| A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth Vitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin) - Vitamin B12 Deficiency | Phase 4 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 46 | 2025-04-16 | 2026-09-04 |
| Efficacy and Safety of Weifuchun Tablet in Reversing Gastric Intestinal Metaplasia Weifuchun, Folic Acid - Gastric Intestinal Metaplasia | Phase 4 | Recruiting | Yongquan Shi | 400 | 2025-02-28 | 2026-08-06 |
| China Stroke Primary Prevention Trial 2 for Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype (CSPPT2-CC/CT) Amlodipine besylate, Amlodipine besylate and folic acid, Amlodipine placebos - Hypertension, MTHFR 677 CC or CT Genotype | Phase 4 | Recruiting | Shenzhen Ausa Pharmed Co.,Ltd | 32000 | 2024-08-22 | 2025-02-26 |
| China Stroke Primary Prevention Trial 2 for Participants With Hypertension and MTHFR 677 TT Genotype Amlodipine besylate, Amlodipine besylate And Folic Acid, 5-methyltetrahydrofolate (5-MTHF) - Hypertension, MTHFR 677 TT Genotype | Phase 4 | Recruiting | Shenzhen Ausa Pharmed Co.,Ltd | 24000 | 2024-08-22 | 2025-02-26 |
| South African Paediatric Surgical Outcomes Study 2 Ferrous gluconate syrup or ferrous fumarate/folic acid tablets - Paediatric Surgery, Anaemia | Phase 4 | Completed | University of Cape Town | 755 | 2023-02-09 | 2025-09-18 |
| Metformin Efficacy and Safety for Gastric Intestinal Metaplasia Metformin, Folate - Gastric Intestinal Metaplasia | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 140 | 2022-04-01 | 2024-09-23 |
| Methotrexate in Erosive Inflammatory Hand Osteoarthritis Methotrexate Tablets, Placebo, Folic Acid 1 MG - Hand Osteoarthritis, Erosive Osteoarthritis | Phase 4 | Active not recruiting | Diakonhjemmet Hospital | 163 | 2021-08-12 | 2026-11-03 |
| Management of Preoperative Anaemia in Surgical Oncology Ferric Carboxymaltose Injection, Folic acid, B12 - Anemia, Tumor | Phase 4 | Unknown | Azienda Ospedaliera Universitaria Integrata Verona | 500 | 2021-03-02 | 2022-08-19 |
| A Study of Serum Folate Levels in Patients Treated With Olaparib Folic Acid Tablet - Ovarian Cancer, Breast Cancer | Phase 4 | Completed | Rush University Medical Center | 10 | 2020-07-21 | 2026-03-04 |
| Study of KRYSTEXXA® (Pegloticase) Plus Methotrexate in Participants With Uncontrolled Gout Pegloticase, methotrexate, placebo - Gout | Phase 4 | Completed | Amgen | 152 | 2019-06-13 | 2024-06-26 |
| The Gut Microbiome in Women With Polycystic Ovary Syndrome dietary advice plus myo-inositol and folic acid, dietary advice plus Liraglutide Pen Injector - PCOS, Obesity | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 21 | 2019-02-28 | 2020-11-04 |
| Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout Pegloticase, Methotrexate (MTX), Standard Gout Flare Prophylaxis - Gout | Phase 4 | Completed | Amgen | 14 | 2018-09-26 | 2024-06-26 |
| Folic Acid in Pediatric Inflammatory Bowel Disease Folic Acid - Inflammatory Bowel Diseases | Phase 4 | Unknown | Le Bonheur Children's Hospital | 100 | 2018-09-11 | 2019-03-01 |
| Optimal MTX Dose With Folic Acid Randomized Case-control Trial MTX, Folic Acid, DMARDs - Rheumatoid Arthritis | Phase 4 | Unknown | Sun Yat-sen University | 160 | 2018-08-01 | 2019-08-26 |
| H-Type Hypertension Precision Medicine Trial Folic Acid, Enalapril Maleate and Folic Acid Tablets (Yiye), Enalapril - Hypertension | Phase 4 | Unknown | Shenzhen Ausa Pharmed Co.,Ltd | 3600 | 2018-03-20 | 2018-07-18 |
| Folic Acid Supplementation as an Appetizer in Primary Malnourished Egyptian Infants and Children Folic Acid - Primary Malnurtrition | Phase 4 | Unknown | Ain Shams University | 100 | 2017-04-01 | 2017-03-14 |
| Comparison of Combination Disease Modifying Antirheumatic Drugs With Methotrexate Therapy in Early Rheumatoid Arthritis Methotrexate, Leflunomide, Hydroxychloroquine - Rheumatoid Arthritis | Phase 4 | Completed | Jawaharlal Institute of Postgraduate Medical Education & Research | 186 | 2015-12-31 | 2019-10-01 |
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Arthritis, Rheumatoid (6) · Polycystic Ovary Syndrome (6) · Hypertension (5) · Schizophrenia (4) · Anemia (2) · Depression (2) · Gout (2) · Hyperhomocysteinemia (2) · Ischemic Stroke (2) · Malaria (2) · Neoplasms (2) · Obesity (2) · Stroke (2) · Abortion, Habitual (1) · Amenorrhea (1)
Shenzhen Ausa Pharmed Co.,Ltd (5) · AGUNCO Obstetrics and Gynecology Centre (4) · Massachusetts General Hospital (3) · Amgen (2) · Hoffmann-La Roche (2) · University Magna Graecia (2) · Ain Shams University (1) · Alexion Pharmaceuticals, Inc. (1) · Azienda Ospedaliera Universitaria Integrata Verona (1) · Bangor University (1) · Bezmialem Vakif University (1) · British University In Egypt (1) · Cambridge Health Alliance (1) · Capital Medical University (1) · Casa de Saúde santa Marcelina (1)
China (11) · Italy (10) · United States (9) · Egypt (3) · Canada (2) · France (2) · India (2) · Spain (2) · United Kingdom (2) · Bangladesh (1) · Belgium (1) · Burkina Faso (1) · Denmark (1) · Ethiopia (1) · Finland (1)
Alice B. Gottlieb, M.D., PhD. (1) · Annemieke Van Eijk, M.D., Ph.D. (1) · Babak Kardavani, M.D. (1) · Donald C. Goff, M.D. (1) · Donald Goff, MD (1) · Eva M Lonn, MD MSc FRCPC FACC (1) · Fanfan Hou, MD (1) · Farideh Khatami, Master of Science (1) · Fulvio Zullo, MD (1) · Gang Wang, M.D. (1) · Georg Noll, MD (1)
PMID 25771069, PMID 21869730, PMID 22230384, PMID 22880024, PMID 29030456, PMID 22897803, PMID 26063325, PMID 27834686, PMID 10069782, PMID 10367822, PMID 10529901, PMID 10946791, PMID 11339434, PMID 16531613, PMID 17470822, PMID 17954810, PMID 18003666, PMID 18047523, PMID 18070815, PMID 18721738, PMID 18831691, PMID 18940900, PMID 19116333, PMID 19228852, PMID 19933994, PMID 21334854, PMID 21562238, PMID 21864249, PMID 21877144, PMID 22850357, PMID 23467813, PMID 24063425, PMID 24328943, PMID 24438922, PMID 24494987, PMID 25391194, PMID 25946554, PMID 26311810, PMID 26474738, PMID 26534874, PMID 26991917, PMID 27052531, PMID 27104192, PMID 27548766, PMID 27729579, PMID 27889300, PMID 28107279, PMID 28122783, PMID 28148501, PMID 28288974
2005 (1), 2023 (1), R01CA133595 (1), R01MH070831 (1)