29 completed, 6 unknown, 3 terminated, 1 not yet recruiting. 40 Phase 1, 14 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 40 | Completed 29, Unknown 6, Terminated 3, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 14 | Completed 6, Terminated 3, Unknown 3, Not yet recruiting 1, Recruiting 1 |
Follow Folic Acid: new trials by email Literature Review of Folic Acid trials Research Report on Folic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Folic Acid Combined With Atezolizumab and Bevacizumab as First-Line Therapy for Unresectable Hepatocellular Carcinoma Folic Acid, Atezolizumab & Bevacizumab - Unresectable Hepatocellular Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | West China Hospital | 78 | 2026-10-01 | 2026-09-23 |
| Prospective Management of Plaque Instability With Statins and Extra Folic Acid Atorvastatin plus folic acid, Atorvastatin - Carotid Atherosclerotic Plaque | Phase 1 / Phase 2 | Recruiting | Ruijin Hospital | 180 | 2026-03-01 | 2026-07-02 |
| Intrathecal Pemetrexed for Leptomeningeal Metastasis Pemetrexed (1), Pemetrexed (2), Folic Acid - Leptomeningeal Metastases | Phase 1 / Phase 2 | Completed | The First Hospital of Jilin University | 34 | 2022-02-21 | 2025-05-04 |
| Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients Pembrolizumab, Pemetrexed, Oxaliplatin - Metastatic Colorectal Cancer | Phase 1 | Unknown | NSABP Foundation Inc | 33 | 2019-05-15 | 2022-06-10 |
| Jianpi Huoxue Recipe in Treating Gastric Premalignant Lesion MoLuoDan, Sanchi powder, Folic Acid Tablet - Gastric Precancerous Condition | Phase 1 / Phase 2 | Unknown | Xiyuan Hospital of China Academy of Chinese Medical Sciences | 480 | 2019-03-01 | 2021-06-25 |
| Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss Sildenafil Citrate, Folic Acid, Placebo Oral Tablet - Miscarriage, Recurrent | Phase 1 | Completed | Ain Shams University | 90 | 2018-01-01 | 2018-12-06 |
| The Effects of Folic Acid on Sudanese Women With Polycystic Ovary Syndrome Folic Acid - Polycystic Ovary Syndrome | Phase 1 / Phase 2 | Unknown | University of Khartoum | 90 | 2017-09-01 | 2017-08-31 |
| [18F]-AZAFOL AS POSITRON EMISSION TOMOGRAPHY (PET) TRACER in FR Positive Cancer Imaging [18F]-AzaFol, folarell - Metastatic Cancer Lung, Metastatic Ovarian Cancer | Phase 1 | Completed | University of Lausanne Hospitals | 15 | 2017-04-01 | 2020-02-28 |
| Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer Pemetrexed, Dexamethasone, Folic Acid - Leptomeningeal Metastases | Phase 1 | Completed | The First Hospital of Jilin University | 13 | 2017-03-01 | 2019-03-19 |
| An Exploratory Study of the Folic Acid-tubulysin Conjugate EC1456 in Ovarian Cancer Subjects Undergoing Surgery EC1456, 99mTc-Etarfolatide - Ovary Cancer | Phase 1 | Completed | Endocyte | 3 | 2017-01-24 | 2019-02-07 |
| Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid Arthritis GSK3196165 Dose 1, GSK3196165 Dose 2, GSK3196165 Dose 3 - Arthritis, Rheumatoid | Phase 1 / Phase 2 | Completed | GlaxoSmithKline | 15 | 2017-01-24 | 2019-06-26 |
| Effect of Food, Rabeprazole, Methotrexate and Formulation on the Pharmacokinetics (PK) of GDC-0853 and the Effect of GDC-0853 on the PK of Methotrexate in Healthy Subjects Folic Acid, GDC-0853, Methotrexate - Healthy Volunteer | Phase 1 | Completed | Genentech, Inc. | 50 | 2015-09-03 | 2020-03-02 |
| Phase I/II Clinical Study of Pralatrexate in Japanese Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Pralatrexate injection, Vitamin B12, Folic Acid - Peripheral T-cell Lymphoma | Phase 1 / Phase 2 | Completed | Mundipharma K.K. | 25 | 2014-03-01 | 2017-11-09 |
| Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) Quercetin, Placebo - sugar chew - Chronic Obstructive Pulmonary Disease | Phase 1 | Completed | University of Michigan | 9 | 2014-02-01 | 2016-12-26 |
| Folic Acid-Tubulysin Conjugate EC1456 In Patients With Advanced Solid Tumors EC1456 and EC20 - Solid Tumors, Non Small Cell Lung Carcinoma | Phase 1 | Completed | Endocyte | 93 | 2013-10-01 | 2019-02-07 |
| Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial methyl donor, Placebo - Heart Rate, Heart Rate Variability | Phase 1 | Completed | Harvard School of Public Health (HSPH) | 10 | 2013-06-01 | 2017-05-11 |
| Long-Term Efficacy and Safety of CT-P10 in Patients With RA Rituximab, MTX, folic acid - Rheumatoid Arthritis | Phase 1 | Completed | Celltrion | 87 | 2013-05-01 | 2015-11-26 |
| Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid Arthritis sarilumab SAR153191 (REGN88), placebo, methotrexate - Rheumatoid Arthritis | Phase 1 | Completed | Sanofi | 61 | 2013-04-01 | 2014-01-28 |
| Quality of Life Study for Sickle Cell Patients Treated With Jobelyn (Sorghum Bicolor Extract) Folic Acid + Paludrine + Jobelyn (500mg), Folic Acid + Paludrine + Jobelyn (250mg), Folic Acid + Paludrine + Jobelyn (2mg) - Other Sickle-cell Disorders With Crisis, Unspecified | Phase 1 / Phase 2 | Unknown | Lagos State University | 96 | 2013-04-01 | 2013-04-04 |
| The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia Paludrine + Folic Acid, Paludrine + Folic Acid + Jobelyn - Sickle Cell Anemia | Phase 1 / Phase 2 | Completed | Lagos State University | 150 | 2012-01-01 | 2012-10-10 |
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Recurrence (5) · Arthritis, Rheumatoid (4) · Colorectal Neoplasms (3) · Ovarian Neoplasms (3) · Anemia, Sickle Cell (2) · Carcinoma, Non-Small-Cell Lung (2) · Colonic Neoplasms (2) · Lung Neoplasms (2) · Lymphoma (2) · Lymphoma, T-Cell (2) · Lymphoma, T-Cell, Cutaneous (2) · Lymphoma, T-Cell, Peripheral (2) · Meningeal Carcinomatosis (2) · Mycosis Fungoides (2) · Rectal Neoplasms (2)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Acrotech Biopharma Inc. (3) · Endocyte (2) · Lagos State University (2) · The First Hospital of Jilin University (2) · Ain Shams University (1) · Bayer (1) · Celltrion (1) · Eli Lilly and Company (1) · Genentech, Inc. (1) · GlaxoSmithKline (1) · Harvard School of Public Health (HSPH) (1) · Hoffmann-La Roche (1) · Institute of Child Health (1) · Jonsson Comprehensive Cancer Center (1)
United States (12) · China (4) · Canada (3) · Japan (3) · United Kingdom (3) · Nigeria (2) · Egypt (1) · Germany (1) · Italy (1) · Netherlands (1) · New Zealand (1) · South Korea (1) · Spain (1) · Sudan (1) · Switzerland (1)
A O Dosunmu, M.D. (2) · Michael Saunders, MD (2) · Alison Armour, MB ChB, BSc, MSc, MD, MRCP (1) · Alison Armour, MD (1) · Andrea Baccarelli, MD PHD MPH (1) · Andrew Copp, Prof (1) · Arun Rajan, M.D. (1) · DaeHyun Yoo, Ph.D (1) · Diane R. Gold, MD (1) · Fernando J Martinez, M.D. (1) · Frances Silverman, PHD (1)
PMID 11877368, PMID 1447744, PMID 15117425, PMID 17118406, PMID 17315026, PMID 19201496, PMID 21067804, PMID 22136481, PMID 22209480, PMID 22606998, PMID 23610531, PMID 24991768, PMID 25103444, PMID 25175924, PMID 25771069, PMID 26123683, PMID 26136594, PMID 26774115, PMID 27243238, PMID 28289216, PMID 28367952, PMID 28475143, PMID 28600696, PMID 28771889, PMID 29549174, PMID 29765016, PMID 30341095, PMID 30781896, PMID 31367538, PMID 31544065, PMID 31591603, PMID 32071149, PMID 32270313, PMID 33309175, PMID 33792686, PMID 35105980, PMID 35704085, PMID 36743906, PMID 36743936, PMID 36829207, PMID 36905458, PMID 40699526, PMID 7595747, PMID 9533527
2009 (1), 2015 (1), P30CA016056 (1), R21AT007357 (1)