7 completed, 4 active not recruiting, 3 recruiting, 1 terminated. 6 Early Phase 1, 4 Phase 1, 2 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 6 | Active not recruiting 3, Completed 3 |
| Phase 1 | 4 | Completed 2, Recruiting 2 |
| Not applicable | 2 | Active not recruiting 1, Completed 1 |
| Phase 2 | 2 | Recruiting 1, Terminated 1 |
Follow Fluorine-18: new trials by email Literature Review of Fluorine-18 trials Research Report on Fluorine-18
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm Fluorethyltyrosine (18-F), Positron Emission Tomography (PET) - Intracranial Neoplasm | Recruiting | Thomas Hope | 199 | 2024-06-21 | 2026-08-27 | |
| Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas Fludeoxyglucose F-18, Gadoterate Meglumine, Contrast-enhanced Magnetic Resonance Imaging - Glioma | Completed | OHSU Knight Cancer Institute | 4 | 2023-12-11 | 2026-06-05 | |
| Imaging Inflammation With Alcohol Use Disorder: an [18F]NOS Study [18F]NOS - Alcohol Use Disorder | Early Phase 1 | Active not recruiting | University of Pennsylvania | 4 | 2023-08-08 | 2025-11-26 |
| Split Course Adaptive Radiation Therapy With Pembrolizumab With/Without Chemotherapy for Treating Stage IV Lung Cancer Biospecimen Collection, Carboplatin, Computed Tomography - Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Vanderbilt-Ingram Cancer Center | 25 | 2023-05-09 | 2024-10-17 |
| Cholinergic Mechanisms of Attentional-motor Integration and Gait Dysfunction in Parkinson Disease (UDALL) (18)F]fluoroethoxybenzovesamicol ([(18)F (FEOBV) PET, Dihydrotetrabenazine (DTBZ) PET - Parkinson Disease, Progressive Supranuclear Palsy | Not applicable | Active not recruiting | University of Michigan | 125 | 2022-03-01 | 2026-07-27 |
| [18F]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma [18F]Fluoroestradiol (FES) PET/CT - Invasive Lobular Breast Carcinoma | Phase 2 | Terminated | University of Utah | 44 | 2020-12-11 | 2025-05-18 |
| Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls [18F]NOS - HIV Infections, Opioid Use | Early Phase 1 | Completed | University of Pennsylvania | 26 | 2020-12-07 | 2026-10-28 |
| Neuroinflammation Imaging in AD [18F]NOS, [11C]PBR28 - Alzheimer Disease, Healthy Volunteer | Early Phase 1 | Active not recruiting | University of Pennsylvania | 9 | 2020-03-03 | 2026-04-14 |
| Evaluation of Neuroinflammation in Parkinson's Disease Using 18F-NOS PET/CT [18F]NOS - Parkinson Disease, Healthy Volunteer | Early Phase 1 | Active not recruiting | University of Pennsylvania | 11 | 2019-08-14 | 2026-05-01 |
| Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation [18F]NOS - Smoking, Cigarette, Smoking E-cigarette | Phase 1 | Recruiting | University of Pennsylvania | 100 | 2018-10-23 | 2026-09-24 |
| Assessing NOS Uptake With PET Imaging in Lung Inflammation Endotoxin (E. coli O:113, Reference Endotoxin), [18F](+/-)NOS - Lung Inflammation | Early Phase 1 | Completed | Washington University School of Medicine | 3 | 2014-05-01 | 2018-07-23 |
| PET Imaging of Endotoxin-induced iNOS Activation Endotoxin (E. coli O:113, Reference Endotoxin), [18F](+/-)NOS - Pneumonia | Phase 1 | Completed | Washington University School of Medicine | 19 | 2010-12-01 | 2014-04-21 |
| iNOS With Positron Emission Tomography (PET) in Cellular Inflammation. [18F](+/-)NOS - Patients With Post Orthotopic Heart Transplantation Status | Early Phase 1 | Completed | Washington University School of Medicine | 26 | 2009-09-01 | 2020-08-07 |
| Detection and Quant of Differences in Hodgkin Lymphoma and Diffuse Large B-cell Lymphoma Using Positron Emission Tomography/Computed Tomography (PET/CT) Fludeoxyglucose F18, Computed Tomography, Positron emission tomography - Lymphoma | Not applicable | Completed | Abramson Cancer Center at Penn Medicine | 10 | 2009-05-01 | 2021-05-18 |
| A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions [18F]FPEB - Parkinson Disease, Huntington Disease | Phase 1 | Completed | Institute for Neurodegenerative Disorders | 48 | 2009-03-01 | 2017-01-06 |
Parkinson Disease (3) · Alzheimer Disease (2) · Pneumonia (2) · Alcohol Drinking (1) · Alcoholism (1) · Autism Spectrum Disorder (1) · Brain Neoplasms (1) · Carcinoma, Lobular (1) · Carcinoma, Non-Small-Cell Lung (1) · Cigarette Smoking (1) · Cognitive Dysfunction (1) · Fragile X Syndrome (1) · Glioma (1) · HIV Infections (1) · Huntington Disease (1)
University of Pennsylvania (5) · Washington University School of Medicine (3) · Abramson Cancer Center at Penn Medicine (1) · Institute for Neurodegenerative Disorders (1) · OHSU Knight Cancer Institute (1) · Thomas Hope (1) · University of Michigan (1) · University of Utah (1) · Vanderbilt-Ingram Cancer Center (1)
United States (15)
Jacob Dubroff, MD, PhD (3) · David Russell, MD (1) · Delphine Chen, MD (1) · Delphine L. Chen, MD (1) · Evan Osmundson, MD, PhD (1) · Jacob Dubroff, MD (1) · Jeffrey Yap, PhD (1) · Martin Pike, Ph.D. (1) · Michael Thomas, MD (1) · Robert J Gropler, MD (1) · Roger Albin, MD (1)
PMID 11463332, PMID 15914468, PMID 25525182, PMID 36919879, PMID 39344233
P30CA068485 (1), P50NS123067 (1)