28 completed, 1 terminated, 1 withdrawn. 10 Phase 2, 6 Phase 1, 6 Phase 3, 4 Not applicable, 3 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 9, Terminated 1 |
| Phase 1 | 6 | Completed 6 |
| Phase 3 | 6 | Completed 6 |
| Not applicable | 4 | Completed 3, Withdrawn 1 |
| Phase 4 | 3 | Completed 3 |
| Early Phase 1 | 2 | Completed 2 |
Follow Florbetapir F 18: new trials by email Literature Review of Florbetapir F 18 trials Research Report on Florbetapir F 18
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of LY3303560 in Participants With Mild Cognitive Impairment or Alzheimer's Disease LY3303560 - IV, Placebo - IV, Florbetapir F 18 - Alzheimer Disease | Phase 1 | Completed | Eli Lilly and Company | 22 | 2017-01-31 | 2023-10-10 |
| Evaluation of Electronic Florbetapir (18F) Interpretation Training in Japanese Physicians Florbetapir (18F) - Alzheimer's Disease | Not applicable | Withdrawn | Avid Radiopharmaceuticals | 2014-10-01 | 2014-10-23 | |
| 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy florbetapir F 18, Flortaucipir F18 - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Avid Radiopharmaceuticals | 41 | 2014-06-01 | 2020-09-07 |
| Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Flortaucipir F18, Florbetapir F 18, Brain PET Scan - Alzheimer's Disease | Phase 2 | Terminated | Avid Radiopharmaceuticals | 44 | 2014-05-01 | 2020-09-07 |
| Florbetapir Calibration to the Centiloid Scale Florbetapir (18F), 11C-PiB - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 35 | 2014-04-01 | 2017-03-09 |
| Evaluation of Reader Training Processes florbetapir F 18 - Alzheimer's Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 241 | 2014-03-01 | 2015-09-28 |
| The Feasibility of Florbetapir Quantitation in Europe Florbetapir (18F) - Alzheimer's Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 96 | 2014-03-01 | 2015-07-09 |
| Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects florbetapir F 18, Flortaucipir F18, Brain PET Scan - Alzheimer's Disease | Phase 2 / Phase 3 | Completed | Avid Radiopharmaceuticals | 383 | 2013-12-01 | 2020-09-22 |
| Exploratory Evaluation of Flortaucipir Injection in Healthy Volunteers and Cognitively Impaired Subjects Flortaucipir F18, Brain PET Scan, Whole body PET scan - Alzheimer Disease | Early Phase 1 | Completed | Avid Radiopharmaceuticals | 36 | 2013-08-16 | 2020-09-25 |
| A Phase II Trial of Florbetapir (18F) Positron Emission Tomography (PET) Imaging in Japan of Healthy Volunteers, Patients With Mild Cognitive Impairment (MCI) and Patients With Alzheimer's Disease (AD) florbetapir (18F) - Alzheimer's Disease, Mild Cognitive Impairment | Phase 2 / Phase 3 | Completed | Avid Radiopharmaceuticals | 48 | 2012-10-01 | 2013-09-19 |
| Effectiveness of Florbetapir (18F) PET Imaging in Changing Patient Management and the Relationship Between Scan Status and Cognitive Decline florbetapir (18F) - Alzheimer's Disease | Phase 4 | Completed | Avid Radiopharmaceuticals | 641 | 2012-10-01 | 2016-08-17 |
| A Study of Florbetapir (18F) in Japanese Healthy Volunteers florbetapir (18F) - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 7 | 2012-08-01 | 2013-09-19 |
| Clinical Evaluation of Florbetapir in Primary Progressive Aphasia Florbetapir F 18, Positron Emission Tomography - Primary Progressive Aphasia, Alzheimer Disease | Completed | University of Chicago | 48 | 2012-03-15 | 2024-10-16 | |
| Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans florbetapir F 18 - Alzheimer Disease, Mild Cognitive Impairment | Not applicable | Completed | Avid Radiopharmaceuticals | 151 | 2011-08-01 | 2012-06-07 |
| Potential of Florbetapir F 18 PET to Inform Clinical Diagnosis and Management of Patients With Progressive Cognitive Decline florbetapir F 18 - Progressive Cognitive Decline | Phase 3 | Completed | Avid Radiopharmaceuticals | 239 | 2011-07-01 | 2013-03-29 |
| Evaluation of Inter-reader Reliability Using Images From Subjects With Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI) florbetapir F 18 - Alzheimer's Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 40 | 2011-02-01 | 2022-08-16 |
| Evaluation of Physician Training Methods to Read Florbetapir-PET Scans florbetapir F 18 - Alzheimer's Disease | Not applicable | Completed | Avid Radiopharmaceuticals | 35 | 2011-01-01 | 2012-06-07 |
| Evaluation of PET Scan Timing Relative to AV-45 Injection Time florbetapir F 18 - Alzheimer's Disease | Not applicable | Completed | Avid Radiopharmaceuticals | 41 | 2010-03-01 | 2012-06-07 |
| Autopsy Follow-up of Subjects Previously Imaged With Florbetapir F 18 (18F-AV-45) PET in Trial 18F-AV-45-A07 florbetapir F 18 - Alzheimer's Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 110 | 2010-03-01 | 2025-03-21 |
| Clinical Evaluation of Florbetapir F 18 (18F-AV-45) Florbetapir F 18 - Alzheimer Disease, Mild Cognitive Impairment | Phase 2 | Completed | Avid Radiopharmaceuticals | 1768 | 2009-12-01 | 2018-07-18 |
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Alzheimer Disease (27) · Cognitive Dysfunction (6) · Neurodegenerative Diseases (2) · Aphasia, Primary Progressive (1) · Chronic Traumatic Encephalopathy (1) · Dementia (1) · Frontotemporal Dementia (1) · Neurocognitive Disorders (1) · Parkinson Disease (1) · Speech Disorders (1)
Avid Radiopharmaceuticals (28) · Eli Lilly and Company (1) · University of Chicago (1)
United States (21) · Japan (4) · United Kingdom (2) · Australia (1) · France (1) · Italy (1) · Netherlands (1)
PMID 22749065, PMID 20501908, PMID 21245183, PMID 24716655, PMID 30969506, PMID 33587110, PMID 37849628, PMID 42467182
2016 (1), R43NS063607 (1)