117 completed, 31 terminated, 26 unknown, 22 withdrawn. 111 Phase 4, 41 Phase 3, 27 Phase 2, 26 Not applicable, 16 Phase 1.
Follow Exparel: new trials by email Literature Review of Exparel trials Research Report on Exparel
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1 Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block - Lung Cancer (Diagnosis) | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2026-10-01 | 2026-08-26 |
| Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia Standard Bupivacaine, Liposomal Bupivacaine - Pain, Postoperative | Phase 2 | Recruiting | Washington University School of Medicine | 45 | 2026-08-01 | 2026-08-18 |
| Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population Exparel - Medial Patellofemoral Ligament (MPFL) Reconstruction, Sports Injuries in Children | Phase 2 | Recruiting | Texas Scottish Rite Hospital for Children | 100 | 2025-12-01 | 2026-03-09 |
| Efficacy of EXPAREL vs. Bupivacaine EXPAREL, 0.25% bupivacaine (HCl): 50 ml, 0.25% bupivacaine (HCl): 30 ml - Total Ankle Arthroplasty, Postsurgical Analgesia | Phase 3 | Recruiting | Emory University | 104 | 2025-11-17 | 2026-02-23 |
| R.E.C.K vs Exparel in Robotic Nephrectomy Ropivacaine HCL, Exparel, Epinephrine - Renal Carcinoma, Nephrectomy / Methods | Phase 3 | Recruiting | Wake Forest University Health Sciences | 170 | 2025-11-14 | 2026-07-13 |
| Postoperative Pain Control in AIS Using Liposomal Bupivacaine vs. 0.25% Bupivacaine With Epinephrine Bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride and Epinephrine Injection - Post Operative Pain, Spinal Fusion | Not applicable | Recruiting | Boston Children's Hospital | 128 | 2025-08-15 | 2025-10-22 |
| Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy Zynrelef, Exparel - Post Operative Pain | Early Phase 1 | Recruiting | Texas Tech University Health Sciences Center | 130 | 2024-11-01 | 2026-07-08 |
| Liposomal Bupivacaine Vs Bupivacaine with Dexmedetomidine in Erector Spinae Plane Blocks for Mastectomies Dexmedetomidine, Liposomal bupivacaine - Breast Cancer | Phase 4 | Recruiting | United States Naval Medical Center, Portsmouth | 200 | 2024-10-15 | 2024-11-19 |
| Post-mastectomy Recovery: Comparing Preoperative PECS-II Blocks With Intraoperative Pectoral Blocks Bupivacain, Exparel, Intraoperative Pecs II block (IOB) & superior AT (EX or BP) - Mastectomy; Lymphedema, Breast Cancer | Phase 4 | Recruiting | University of Cincinnati | 100 | 2024-09-25 | 2025-11-04 |
| EXPAREL IPSA Block in Knee Arthroplasty Exparel - Pain, Postoperative, Osteo Arthritis Knee | Phase 4 | Unknown | Campbell Clinic | 10 | 2024-05-20 | 2024-10-01 |
| Comparison of the Ultrasound-guided Paravertebral Nerve Block With Liposomal Bupivacaine Versus Ropivacaine for Post-Surgical Pain After Video-Assisted Thoracoscopic Surgery Liposomal bupivacaine, Ropivacaine - Analgesia | Phase 3 | Unknown | Feng Gao | 84 | 2024-05-10 | 2024-05-08 |
| Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion Exparel, Bupivacain - Back Pain, Surgery-Complications | Phase 2 / Phase 3 | Enrolling by invitation | Foundation for Orthopaedic Research and Education | 76 | 2024-04-30 | 2026-09-09 |
| Liposomal Bupivacaine Use in Alveolar Bone Graft Patients Liposomal Bupivacaine, Bupivacain, Epinephrine - Cleft Lip and Palate | Phase 3 | Unknown | Kerry O'Rourke | 60 | 2024-04-24 | 2024-07-03 |
| Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery Liposomal bupivacaine, Bupivacaine Hydrochloride - Distal Radius Fractures, Wrist Fractures | Phase 3 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2024-04-10 | 2025-10-24 |
| Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery EXPAREL, bupivacaine - Postoperative Pain | Phase 1 | Recruiting | Pacira Pharmaceuticals, Inc | 48 | 2024-03-29 | 2025-12-29 |
| Liposomal Bupivacaine + Bupivacaine vs. Bupivacaine Alone on Opioid Use After Elective c/Section Liposomal bupivacaine, Bupivacaine HCl - Postoperative Pain, Cesarean Section | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2024-03-01 | 2024-04-10 | |
| A Study of Liposomal Bupivacaine Versus 0.25% Bupivacaine Hydrochloride Post Breast Reduction Bupivacaine Hydrochloride, Liposomal Bupivacaine - Breast Reduction | Phase 4 | Completed | Mayo Clinic | 32 | 2024-01-24 | 2025-12-15 |
| Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride - Pain, Postoperative, Opioid Use | Phase 2 / Phase 3 | Enrolling by invitation | Rutgers, The State University of New Jersey | 150 | 2024-01-11 | 2026-02-17 |
| Pilot: Intraoperative TAP Block and Post-operative Pain Control for Minimally Invasive Hysterectomy for Endometrial Cancer Liposomal bupivacaine, Bupivacain - Post Operative Pain, Gynecologic Cancer | Phase 3 | Completed | Tufts Medical Center | 15 | 2024-01-01 | 2025-04-24 |
| Utility of Exparel Based ESP Blocks in Elective Posterior Spine Fusion Liposomal bupivacaine, Bupivacaine - Spine Fusion, Anesthesia, Local | Phase 4 | Unknown | Hartford Hospital | 100 | 2023-12-01 | 2023-10-30 |
Showing 20 of 223. Sign in to see all of them.
Pain, Postoperative (71) · Pain (35) · Agnosia (34) · Rotator Cuff Injuries (10) · Osteoarthritis, Knee (9) · Breast Neoplasms (7) · Osteoarthritis (6) · Shoulder Pain (5) · Acute Pain (4) · Bunion (4) · Ankle Fractures (3) · Anterior Cruciate Ligament Injuries (3) · Disease (3) · Hernia (3) · Opioid-Related Disorders (3)
Pacira Pharmaceuticals, Inc (29) · Mayo Clinic (9) · Wake Forest University Health Sciences (6) · Henry Ford Health System (4) · M.D. Anderson Cancer Center (4) · Maimonides Medical Center (4) · The Cleveland Clinic (4) · TriHealth Inc. (4) · Emory University (3) · Loma Linda University (3) · Massachusetts General Hospital (3) · OhioHealth (3) · OrthoCarolina Research Institute, Inc. (3) · Rothman Institute Orthopaedics (3) · St. Luke's Hospital, Pennsylvania (3)
United States (200) · Denmark (4) · Belgium (2) · China (1) · Czechia (1) · Georgia (1) · Hong Kong (1) · Poland (1) · United Kingdom (1)
Ali Shariat, MD (3) · James B Jones, MD, PharmD (3) · Amanda Kumar, MD (2) · Erol Onel, MD (2) · Gary Nevins (2) · Igor Grachev, MD, PhD (2) · Jorge Marcet, MD (2) · Kay Warnott, RN (2) · Risal Djohan, MD (2) · Susan M Odum, PhD (2) · Abdelrahman Nimeri, MD (1) · Adam Schumaier, MD (1) · Ajay Aggarwal, MD (1) · Albert Losken, MD (1) · Alisan Fathalizadeh, M.D (1)
PMID 22900785, PMID 33372953, PMID 22067185, PMID 22227789, PMID 24108252, PMID 25912739, PMID 26507422, PMID 31150095, PMID 12576361, PMID 12873949, PMID 1517644, PMID 15220782, PMID 15919269, PMID 16625122, PMID 17341537, PMID 17961838, PMID 18183534, PMID 19247744, PMID 19359920, PMID 20027030, PMID 20048659, PMID 20175754, PMID 21256488, PMID 21716105, PMID 21716734, PMID 21842428, PMID 22013534, PMID 22179931, PMID 22323951, PMID 22695321, PMID 23049275, PMID 23403516, PMID 23411725, PMID 23614099, PMID 24436846, PMID 24458051, PMID 24496168, PMID 24817851, PMID 25018650, PMID 25210700, PMID 25282071, PMID 25527168, PMID 25683770, PMID 25822923, PMID 25866297, PMID 26090281, PMID 26204387, PMID 26308513, PMID 26447431, PMID 26543383
2016 (2), P30CA077598 (1), UL1TR000135 (1)