52 completed, 13 unknown, 10 recruiting, 5 terminated. 87 Phase 2, 14 Phase 1, 12 Phase 3.
Follow Ethanol: new trials by email Literature Review of Ethanol trials Research Report on Ethanol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 60 | 2026-12-01 | 2026-10-21 |
| Effect of Moderate Alcohol on Absorption and Onset of Hezkue Sildenafil Suspension Hezkue Sildenafil Oral Suspension, Moderate Alcohol Intake - Erectile Dysfunction | Phase 2 | Not yet recruiting | Aspargo Labs, Inc | 36 | 2026-04-15 | 2025-12-18 |
| Effects of Ketone Supplement and Alcohol on Brain Metabolism Kenetik, Alcohol beverage - Ketosis, Alcohol Drinking | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 60 | 2025-05-13 | 2026-10-14 |
| Efficacy of a Smartphone-Based JITAI to Reduce Drinking Among Adults Experiencing Homelessness Smart-T Alcohol, Usual Care - Alcohol Misuse, Homeless | Phase 2 / Phase 3 | Recruiting | University of Oklahoma | 600 | 2025-03-05 | 2026-05-01 |
| Comparison of the Effect of Red Wine With Alcohol on Flow-mediated Dilation Versus Red Wine Without Alcohol red wine with alcohol, red wine without alcohol - Healthy, Healthy Diet | Phase 1 / Phase 2 | Unknown | Instituto de Cardiologia de Santa Catarina | 15 | 2024-08-13 | 2024-08-16 |
| Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH Placebo, Half dose CBD, Full dose CBD - Severe Alcohol Use Disorder (DSM 5) | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 210 | 2024-04-08 | 2025-12-03 |
| Effect of Nutritional Ketosis on Alcohol Metabolism Ketone Supplement, Control Diet, Ketogenic diet - Ketoses, Metabolic, Ketogenic Dieting | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 23 | 2024-02-29 | 2026-04-07 |
| Motivation for IV Alcohol Self-Administration in Humans Intravenous Alcohol - Alcohol Use Disorder | Phase 2 | Recruiting | University of California, Los Angeles | 210 | 2024-01-16 | 2026-05-01 |
| EGCG for the Prevention and Treatment of TIPN Epigallocatechin-3-Gallate, Alcohol - Chemotherapy-induced Peripheral Neuropathy | Phase 1 / Phase 2 | Unknown | Han Xi Zhao | 36 | 2023-11-30 | 2024-07-29 |
| Guanfacine Extended-release for Adolescents With Cannabis Use Guanfacine Extended Release Oral Tablet, Residential withdrawal, Engagement with alcohol and other drug services - Cannabis Use Disorder | Phase 2 | Recruiting | Orygen | 100 | 2023-07-27 | 2025-07-31 |
| Neural Correlates During Alcohol Intoxication Alcohol (Ethanol), Placebo - Alcohol Use Disorder, Intermittent Explosive Disorder | Phase 2 | Recruiting | Ohio State University | 144 | 2023-06-08 | 2025-03-27 |
| Venous Ethanol for Ventricular Tachycardia Venous ethanol, Catheter ablation - Ventricular Tachycardia, Ischemic Cardiomyopathy | Phase 2 | Recruiting | The Methodist Hospital Research Institute | 156 | 2023-04-12 | 2026-07-24 |
| Cannabis' Impact on Alcohol Consumption THC-dominant cannabis, CBD-dominant cannabis, Cannabis placebo - Alcohol Drinking, Cannabis Use | Phase 2 | Recruiting | Brown University | 350 | 2023-03-16 | 2026-10-05 |
| The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality LSD, Ethanol - Prosocial Behavior | Phase 1 / Phase 2 | Unknown | Maastricht University | 60 | 2023-01-01 | 2023-01-04 |
| Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers Ketone Supplement, Alcohol Beverage - Alcohol Drinking | Phase 2 / Phase 3 | Active not recruiting | University of Pennsylvania | 10 | 2022-10-20 | 2026-08-06 |
| Effects of Cannabis/Alcohol on Driving Performance and Field Sobriety Tests Cannabis, Alcohol - Driving Impaired, Alcohol Intoxication | Phase 1 / Phase 2 | Withdrawn | University of California, San Diego | 2022-08-01 | 2023-09-07 | |
| Inhaled Isopropyl Alcohol for Treatment of Nausea Inhaled Isopropyl Alcohol, Oral Ondansetron, Inhaled Placebo - Vomiting, Nausea | Phase 2 / Phase 3 | Recruiting | State University of New York at Buffalo | 84 | 2022-04-20 | 2026-09-24 |
| Dermal Irritation, Sensitization and Cumulative Irritation Potential of 6% Bemotrizinol 6% Bemotrizinol (BEMT) in a basic sunscreen oil formulation, 6% Bemotrizinol (BEMT) dispersion in petrolatum, Sunscreen oil vehicle with 10% ethanol as penetration enhancer without BEMT - Sunburn | Phase 2 | Completed | dsm-firmenich Switzerland AG | 224 | 2022-02-23 | 2022-08-26 |
| Ketone Ester Intervention in Alcohol Use Disorder Ketone Ester "(R)-3-hydroxybutyl (R)-3-hydroxybutyrate", Isocaloric dextrose placebo, Alcohol drinks - Alcohol Drinking, Alcohol Use Disorder | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 20 | 2021-04-05 | 2026-02-09 |
| Antiseptic Mouthwash / Pre-Procedural Rinse on SARS-CoV-2 Load (COVID-19) Oral-B Mouth Sore mouthwash, Crest Pro-Health Multi-Protection mouthwash, CloSYS Ultra Sensitive Rinse mouthwash - COVID-19, SARS-CoV 2 | Phase 2 | Terminated | University of California, San Francisco | 54 | 2021-03-31 | 2023-11-18 |
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Alcoholism (18) · Alcohol Drinking (13) · Substance-Related Disorders (5) · Surgical Wound Infection (4) · Alcoholic Intoxication (3) · Depression (3) · Hypertension (3) · Infections (3) · Ketosis (3) · Marijuana Abuse (3) · Tobacco Use Disorder (3) · Alopecia (2) · Behavior, Addictive (2) · Brain Neoplasms (2) · COVID-19 (2)
University of Pennsylvania (5) · The University of Tennessee, Knoxville (3) · University of Johannesburg (3) · Brown University (2) · Direct Therapeutics (2) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2) · Solventum US LLC (2) · Topical Remedy (2) · University of California, Los Angeles (2) · University of California, San Francisco (2) · Zurex Pharma, Inc. (2) · Ablative Solutions, Inc. (1) · American Medical Systems (1) · Amgen (1) · Arlene Fink Associates (1)
United States (55) · France (5) · Netherlands (3) · South Africa (3) · United Kingdom (3) · Iran (2) · Portugal (2) · Argentina (1) · Australia (1) · Belgium (1) · Brazil (1) · Canada (1) · China (1) · Denmark (1) · Egypt (1)
Corinde Wiers, Ph.D. (3) · Elizabeth Solomon, D.TechHom (2) · Gene David Resnick, MD (2) · Rozalia Olsavszky, MD (2) · Alan Marion, MD (1) · Alana Koehler, MD (1) · Aleksandra Zgierska, MD PhD (1) · Amber U Luong, MD, PhD (1) · Arlene Fink (1) · Atul Pathak, Prof. (1) · Bart JA Rijnders, MD, PhD (1) · Benjamin A. Toll, Ph.D. (1) · Bernard Le Foll, MD, PhD (1) · Bertrand Souweine, Pr (1) · Celia Morgan, Ph.D. (1)
PMID 15094417, PMID 17063973, PMID 17848609, PMID 17916224, PMID 18837602, PMID 20520776, PMID 20878941, PMID 21049267, PMID 21859168, PMID 22297835, PMID 25419583, PMID 26144593, PMID 26257143, PMID 26542471, PMID 26832213, PMID 27018532, PMID 27473868, PMID 27535024, PMID 27936818, PMID 28372596, PMID 28461283, PMID 28576557, PMID 28802565, PMID 29133954, PMID 29566104, PMID 31527291, PMID 32335895, PMID 32485203, PMID 32958438, PMID 33345865, PMID 34173005, PMID 35012326, PMID 36571611, PMID 37142273, PMID 37692969, PMID 39526682, PMID 39739971, PMID 41329966, PMID 42238425
R21AA031088 (2), 1DP5OD019809 (1), K23AA017508 (1), P60AA013759 (1), R00AA026892 (1), R01AA012518 (1), R01AA013895 (1), R01AA014193 (1), R01AA014270 (1), R01AA016315 (1), R01AA019671 (1), R01AA025930 (1), R01AA029701 (1), R01AA029711 (1), R01AA031280 (1)