47 completed. 47 Phase 2, 10 Phase 1, 9 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 47 | Completed 47 |
| Phase 1 | 10 | Completed 10 |
| Phase 3 | 9 | Completed 9 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Can PLIA Reduce Early Post-operative Pain After PAO Surgery? Ropivacaine, Epinephrine, Ketorolac, NaCl (Saline) - Hip Dysplasia | Phase 2 / Phase 3 | Completed | Michael C Willey | 121 | 2024-10-03 | 2026-10-07 |
| Pharmacokinetics Study of DESF in Adults With Oral Allergy Syndrome DESF, Epinephrine Injection - Allergic Reaction | Phase 2 | Completed | Aquestive Therapeutics | 36 | 2024-07-17 | 2025-09-26 |
| Epinephrine Nasal Drops for Epistaxis During Nasal Intubation epinephrine nasal drops, oxymetazoline nasal drops - Oral Surgery | Phase 2 | Completed | Universitas Padjadjaran | 40 | 2024-01-01 | 2025-01-23 |
| Different Volumes of Articaine for Inferior Alveolar Nerve Block in Irreversible Pulpitis Articaine HCl 4 % / EPINEPHrine 1:100,000 in 1.8 mL Dental Cartridge - Drug Effect, Pulpitis - Irreversible | Phase 2 | Completed | Armed Forces Institute of Dentistry, Pakistan | 78 | 2023-12-01 | 2024-10-15 |
| Comparative Bioavailability of Intranasal Epinephrine A: Epinephrine injection, B: FMXIN002 3.6mg, C: FMXIN002 4.0mg - Anaphylaxis, Anaphylactic Reaction | Phase 1 / Phase 2 | Completed | Nasus Pharma | 12 | 2023-08-22 | 2025-06-18 |
| Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible Pulpitis 2% lignocaine with epinephrine 1.8 ml(36mg/ml lignocaine HCL, epinephrine bitartrate 0.0324mg/ml), 4% Articaine with epinephrine 1.7 ml (40mg/ml Articaine HCL, epinephrine bitartrate 0.018 mg/ml) - Symptomatic Irreversible Pulpitis | Phase 2 | Completed | 28 Military Dental Centre Lahore | 123 | 2022-12-19 | 2025-03-06 |
| HTX-011 in Spinal Surgery Bupivacaine HCI without epinephrine, HTX-011, Luer Lock Applicator - Post-Operative Pain, Lumbar Laminectomy | Phase 2 | Completed | Heron Therapeutics | 32 | 2022-04-07 | 2023-06-12 |
| Impact of Perioperative Levosimendan on Patients Undergoing Cardiac Surgery With Low Ejection Fraction levosemindan, adrenaline,noreadrenaline,dopamine and doputamine - Cardiac Surgery, Low Ejection Fraction | Phase 2 | Completed | Zagazig University | 240 | 2021-01-01 | 2025-01-20 |
| Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty Multimodal Drug, epinephrine, celecoxib - Postoperative Pain, Total Knee Arthroplasty | Phase 2 | Completed | Isfahan University of Medical Sciences | 146 | 2021-01-01 | 2022-04-14 |
| RCT Comparing ESPB Solutions in Breast Surgery Liposomal bupivacaine, Bupivacaine, epinephrine, dexamethasone, and clonidine - Breast Cancer | Phase 2 | Completed | Tufts Medical Center | 75 | 2020-12-04 | 2025-01-10 |
| Functional Endoscopic Sinus Surgery Study Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 1, Bupivacaine or Ropivacaine with epinephrine plus dexamethasone - Group 2 - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Completed | University of Florida | 80 | 2019-09-25 | 2026-07-30 |
| Articaine Efficacy and Safety for Children Below Age of 4-years Articaine 4%/Epi 1:100000 Inj Cart 1.7Ml, lidocaine hydrochloride 2% and epinephrine 1:100000 - Behaviour Assessment, Pain | Phase 1 / Phase 2 | Completed | Minia University | 184 | 2019-08-25 | 2020-02-17 |
| Surgicel and Analgesic Reservoir "Local Anesthetic", "Epinephrine" and "Morphine", "Local Anesthetic", "Epinephrine", "Morphine" and "Surgicel", "Normal Saline" - Postoperative Pain | Phase 2 / Phase 3 | Completed | Assiut University | 90 | 2018-11-15 | 2020-08-18 |
| Can Epinephrine Coated Syringe for Subcutaneous Immunotherapy (SCIT) Reduce Large Local Reaction? Epinephrine or normal saline - Injection Reactions Site, Systemic Reactions | Phase 1 / Phase 2 | Completed | Mahidol University | 17 | 2018-10-24 | 2020-02-20 |
| M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers M7824, Topotecan, Temozolomide - Carcinoma, Small Cell, Lung Cancer | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 37 | 2018-09-11 | 2025-05-09 |
| To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor 3% Mepivacaine Hydrochloride, 2% Mepivacaine with 1:100,000 epinephrine - LOCAL ANESTHESIA | Phase 2 | Completed | Afshan Amjad Ali | 60 | 2018-05-30 | 2021-07-01 |
| Quadratus Lumborum Block Versus Control for Total Hip Arthroplasty Quadratus Lumborum Block (QLB), Standard of Care - Total Hip Arthroplasty | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 80 | 2018-04-01 | 2021-06-09 |
| Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung Biopsies Topical epinephrine, Placebos - Lung Transplant; Complications, Mechanical, Lung Transplant; Complications | Phase 2 / Phase 3 | Completed | University of Maryland, Baltimore | 66 | 2017-07-01 | 2024-08-28 |
| Study to Compare Active Tymbion Iontophoresis to Sham Tymbion Iontophoresis for Anesthesia of the Tympanic Membrane Tymbion Lidocaine/epinephrine solution, Device: Iontophoresis System (IPS) with Drug: Tymbion lidocaine/epinephrine solution - Healthy Volunteer | Phase 2 | Completed | Tusker Medical | 40 | 2017-04-27 | 2020-01-18 |
| IINB vs. QLB for Elective Open Inguinal Herniorrhaphy Ilioinguinal / Iliohypogastric Block, Quadratus Lumborum Block, Bupivacaine 0.25% - Nerve Block, Herniorrhaphy | Phase 2 | Completed | Wake Forest University Health Sciences | 60 | 2017-01-30 | 2019-11-18 |
Showing 20 of 47. Sign in to see all of them.
Pain, Postoperative (10) · Pain (7) · Agnosia (4) · Anaphylaxis (2) · Asthma (2) · Breast Neoplasms (2) · Bronchial Spasm (2) · Heart Arrest (2) · Hypersensitivity (2) · Hypotension (2) · Shock, Septic (2) · Acute Lung Injury (1) · Angioedema (1) · Carcinoma, Small Cell (1) · Diabetes Insipidus (1)
Pacira Pharmaceuticals, Inc (3) · Amphastar Pharmaceuticals, Inc. (2) · Heron Therapeutics (2) · Isfahan University of Medical Sciences (2) · Islamic Azad University, Sanandaj (2) · National Cancer Institute (NCI) (2) · University of Florida (2) · 28 Military Dental Centre Lahore (1) · Afshan Amjad Ali (1) · American Hip Institute (1) · Aquestive Therapeutics (1) · Armed Forces Institute of Dentistry, Pakistan (1) · Assiut University (1) · Cairo University (1) · Hopital Foch (1)
United States (23) · Egypt (4) · France (4) · Iran (4) · Pakistan (3) · Thailand (3) · Canada (1) · Czechia (1) · Georgia (1) · Greece (1) · Indonesia (1) · Israel (1) · Italy (1) · Norway (1)
Eric Bellissant, MD, PhD (2) · Ahmad Elheeny (1) · Ahmad H Aboul Soud, MD (1) · Ahmad H Mohamed, MD (1) · Alain Mina, M.D. (1) · Anish Thomas, M.D. (1) · Ayman A Ghoneim, MD (1) · Benjamin G Domb, MD (1) · Benno von Bormann, MD (1) · Cameron R Smith (1) · Charis Roussos, Professor (1) · Charles Phillips, M.D. (1) · Christopher J Edwards, MD (1)
PMID 22900785, PMID 11133630, PMID 12298311, PMID 12411815, PMID 12934209, PMID 15513495, PMID 16452738, PMID 16507156, PMID 16651569, PMID 17650835, PMID 17720019, PMID 19139319, PMID 19214642, PMID 19520544, PMID 19535720, PMID 1977542, PMID 19934423, PMID 21195945, PMID 2367246, PMID 25187581, PMID 25302181, PMID 26056838, PMID 2771438, PMID 29033152, PMID 30100052, PMID 30904852, PMID 31653800, PMID 32423275, PMID 32765052, PMID 33492696, PMID 34990764, PMID 34996918, PMID 37140517, PMID 38991714, PMID 40331908, PMID 42365874, PMID 42820295
2014 (1)