12 completed. 12 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 12 |
| Phase 2 | 1 | Completed 1 |
Follow Endotoxin: new trials by email Literature Review of Endotoxin trials Research Report on Endotoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aging and Reward System Response to Inflammation and Anxiety Study Endotoxin, Placebo - Anhedonia, Inflammation | Phase 1 | Completed | University of California, Los Angeles | 40 | 2023-03-29 | 2025-12-11 |
| Sleep and Healthy Aging Research on Depression for Younger Women Endotoxin, Placebo - Anhedonia, Depression | Phase 1 | Completed | University of California, Los Angeles | 40 | 2019-10-02 | 2026-01-27 |
| Effects of 20,000 EU of Clinical Center Reference Endotoxin (CCRE) Versus Placebo(ENDOHEART) Clinical Center Reference Endotoxin (CCRE), Normal saline - Healthy | Phase 1 | Completed | University of North Carolina, Chapel Hill | 15 | 2018-10-17 | 2019-09-20 |
| Sleep and Healthy Aging Research for Depression (SHARE-D) Study Endotoxin, Placebo - Depression in Old Age | Phase 1 | Completed | Michael Irwin, MD | 160 | 2017-08-23 | 2024-09-05 |
| Adrecizumab-LPS Study Endotoxin, Placebo, Adrecizumab - Healthy Volunteers | Phase 1 | Completed | Adrenomed AG | 24 | 2017-01-04 | 2021-02-01 |
| Dose-Related Inflammatory Effects of Intravenous Endotoxin in Humans Endotoxin, Placebo - Healthy | Phase 1 | Completed | Robert J Noveck, M.D. | 23 | 2016-08-01 | 2017-04-11 |
| PK/PD of EA-230 During Endotoxemia EA-230, Endotoxin, Placebo - Endotoxemia, Systemic Inflammatory Response | Phase 1 | Completed | Radboud University Medical Center | 60 | 2015-02-01 | 2016-06-23 |
| Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood WT1 Peptide-Pulsed Dendritic Cells, Donor Lymphocytes, IL-4 - Leukemia, Acute Myelogenous (AML), Leukemia, Acute Lymphocytic (ALL) | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 10 | 2008-02-22 | 2017-04-12 |
| Effect of Selective iNOS Inhibition During Human Endotoxemia Aminoguanidine, endotoxin - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 7 | 2005-01-01 | 2008-04-15 |
| Carbon Monoxide to Prevent Lung Inflammation Bronchoscopy, Bronchoalveolar lavage, Endotoxin - Respiratory Distress Syndrome, Adult | Phase 1 | Completed | National Institutes of Health Clinical Center (CC) | 35 | 2004-10-13 | 2019-12-17 |
| Blockade of Vascular Potassium Channels During Human Endotoxemia endotoxin, Potassium channel blockers: TEA, Quinin, Tolbutamide, L-NMMA - Endotoxemia | Phase 1 | Completed | Radboud University Medical Center | 36 | 2003-01-01 | 2008-10-17 |
| Effect of a 10,000 EU Dose of Endotoxin in Allergic and Mildly Asthmatic Adults Clinical Center Reference Endotoxin (CCRE) - Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal | Phase 1 | Completed | University of North Carolina, Chapel Hill | 11 | 2002-10-01 | 2009-12-09 |
Depression (3) · Endotoxemia (3) · Anhedonia (2) · Inflammation (2) · Anxiety Disorders (1) · Asthma (1) · Hematologic Neoplasms (1) · Hodgkin Disease (1) · Hypersensitivity (1) · Leukemia (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, Non-Hodgkin (1) · Myelodysplastic Syndromes (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1)
Radboud University Medical Center (3) · University of California, Los Angeles (2) · University of North Carolina, Chapel Hill (2) · Adrenomed AG (1) · Michael Irwin, MD (1) · National Cancer Institute (NCI) (1) · National Institutes of Health Clinical Center (CC) (1) · Robert J Noveck, M.D. (1)
United States (8) · Netherlands (3)
Peter Pickkers, MD, PhD (2) · Anthony F Suffredini, M.D. (1) · Chloe C Boyle, PHD (1) · Chloe C Boyle, PhD (1) · David Peden, MD (1) · Michael R Irwin, MD (1) · Michelle Hernandez, MD (1) · P Pickkers, MD, Prof. (1) · Peter Pickkers, PhD (1) · Robert J Noveck, MD, PhD (1) · Terry J Fry, M.D. (1)
PMID 41298372, PMID 16864730, PMID 30919998, PMID 35868533, PMID 37256193, PMID 40668551, PMID 41192236
K01AG072049 (1)