36 completed, 5 unknown, 3 terminated, 1 not yet recruiting. 11 Phase 1, 10 Phase 3, 9 Phase 4, 8 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 11 |
| Phase 3 | 10 | Completed 7, Terminated 2, Unknown 1 |
| Phase 4 | 9 | Completed 6, Unknown 2, Terminated 1 |
| Phase 2 | 8 | Completed 6, Unknown 2 |
| Not applicable | 2 | Completed 2 |
Follow Donepezil Hydrochloride: new trials by email Literature Review of Donepezil Hydrochloride trials Research Report on Donepezil Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rivastigmine Mini-Tablet for Alzheimer's Disease Rivastigmine Mini-Tablet, Donepezil Hydrochloride - Alzheimer's Disease | Not yet recruiting | Peking University First Hospital | 1000 | 2025-02-28 | 2025-02-20 | |
| Ultrasound-Guided Stellate Ganglion Block for Alzheimer's Disease Ultrasound-Guided Stellate Ganglion Block, Memantine hydrochloride, Donepezil hydrochloride - Alzheimer's Disease(AD), Cognitive Dysfunction | Not applicable | Completed | Taizhou Second People's Hospital | 40 | 2025-01-26 | 2026-01-21 |
| Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease Donepezil Hydrochloride, Placebo - Parkinson Disease, Mild Cognitive Impairment | Phase 2 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 120 | 2023-10-01 | 2023-09-28 |
| Progress of Mild Alzheimer's Disease in Participants on Acupuncture Versus Sham Acupuncture Active acupuncture, Sham acupuncture, Donepezil Hydrochloride - Alzheimer Disease 1 | Not applicable | Completed | Shanghai Institute of Acupuncture, Moxibustion and Meridian | 160 | 2022-06-30 | 2026-05-22 |
| Cognition Platform Study in Participants at Risk for Alzheimer's Disease (AD) (MK-0000-413) Donepezil, Placebo - Alzheimer's Disease, Mild Cognitive Impairment | Phase 1 | Completed | Merck Sharp & Dohme LLC | 44 | 2021-03-23 | 2024-10-28 |
| Single-ascending Dose Phase 1 Clinical Trial to Evaluate the Safety and PK of DA-5207 TDS in Healthy Adults DA-5207, Donepezil Hydrochloride - Healthy | Phase 1 | Completed | Dong-A ST Co., Ltd. | 40 | 2019-06-18 | 2021-04-14 |
| The Effect of Donepezil in Radiotherapy-related Cognitive Impairment. Donepezil Hydrochloride, Placebo - Radiation Injuries, Cognitive Impairment | Phase 2 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 238 | 2019-05-01 | 2019-11-25 |
| A Based on PEEG and PET Study of Anxiolytic Treatment to Improve Cognitive Function in Patients With Alzheimer Disease Tandospirone Citrate, Donepezil Hydrochloride - Alzheimer Disease, Cognitive Function | Phase 4 | Unknown | Zhejiang Provincial People's Hospital | 30 | 2017-05-20 | 2017-05-12 |
| Post-marketing Surveillance of Donepezil Hydrochloride - Investigation of Long Term Safety and Efficacy of Aricept as Well as Its Proper Use Information in Patients With Dementia With Lewy Bodies (DLB). Donepezil Hydrochloride - Dementia With Lewy Body Disease | Completed | Eisai Co., Ltd. | 591 | 2015-04-20 | 2018-07-11 | |
| Multicenter Evaluation of Memory Remediation After TBI With Donepezil Donepezil, Placebo - Traumatic Brain Injury, Memory Deficits | Phase 3 | Completed | Baylor College of Medicine | 75 | 2013-09-01 | 2025-01-15 |
| A Study of Donepezil Hydrochloride in Patients With Dementia Associated With Cerebrovascular Disease Donepezil hydrochloride, Donepezil matching placebo - Dementia Associated With Cerebrovascular Disease | Phase 4 | Completed | Eisai Co., Ltd. | 302 | 2013-08-05 | 2020-01-10 |
| Pharmacokinetics and Pharmacodynamics (PK/PD) of CEP-26401 in Healthy Subjects CEP-26401, donepezil hydrochloride, modafinil - Cognitive Impairment | Phase 1 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 40 | 2013-08-01 | 2014-04-03 |
| Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Factors That Affect Aricept Medication Persistence Rate and the Safety and Efficacy in Patients With Alzheimer's Disease in Clinical Practice Donepezil Hydrochloride - Alzheimer's Disease | Completed | Eisai Co., Ltd. | 8662 | 2013-06-01 | 2018-09-07 | |
| Post-marketing Surveillance of Donepezil Hydrochloride Investigation of the Safety and Effectiveness of Combination Therapy of Donepezil Hydrochloride and Memantine Hydrochloride in Patients With Alzheimer's Disease Donepezil Hydrochloride - Alzheimer's Desease | Completed | Eisai Co., Ltd. | 3482 | 2013-06-01 | 2018-09-07 | |
| Study of Donepezil in Female Breast Cancer Survivors With Cognitive Dysfunction donepezil hydrochloride, Placebo - Anxiety Disorder, Breast Cancer | Phase 2 | Completed | Wake Forest University Health Sciences | 62 | 2012-07-01 | 2021-10-20 |
| A Bioequivalence Study Comparing Improved Versus Current Orally Disintegrating E2020 10 mg Tablet in Healthy Japanese Adult Males Donepezil Hydrochloride - Healthy Adult | Phase 1 | Completed | Eisai Co., Ltd. | 20 | 2011-07-01 | 2012-06-27 |
| A Double-blind, Placebo-controlled Trial of Donepezil Adjunctive Treatment for Cognitive Impairment in Schizophrenia Donepezil, placebo - Impaired Cognition, Schizophrenia | Phase 4 | Unknown | Central South University | 80 | 2011-06-01 | 2011-12-13 |
| A Bioequivalence Study of Film-coated Tablet and Dry Syrup 1% Form for E2020 in Healthy Japanese Adult Males Donepezil Hydrochloride - Healthy Adult | Phase 1 | Completed | Eisai Co., Ltd. | 12 | 2011-03-01 | 2012-01-10 |
| Post-marketing Surveillance of Donepezil Hydrochloride -Investigation of the Clinical Safety and Effectiveness in Patients With Alzheimer's Disease donepezil hydrochloride - Alzheimer's Disease | Completed | Eisai Co., Ltd. | 894 | 2010-12-01 | 2023-07-24 | |
| Post-marketing Surveillance of Long-term Administration of Donepezil Hydrochloride -Investigation of the Clinical Condition and Safety in Patients With Alzheimer's Disease- donepezil hydrochloride - Alzheimer's Disease | Completed | Eisai Co., Ltd. | 10238 | 2010-06-10 | 2018-11-05 |
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Alzheimer Disease (15) · Cognitive Dysfunction (11) · Radiation Injuries (4) · Cognition Disorders (3) · Dementia (3) · Depression (3) · Memory Disorders (3) · Anxiety Disorders (2) · Astrocytoma (2) · Brain Neoplasms (2) · Choroid Plexus Neoplasms (2) · Craniopharyngioma (2) · Down Syndrome (2) · Ependymoma (2) · Fatigue (2)
Eisai Inc. (10) · Eisai Co., Ltd. (9) · Wake Forest University Health Sciences (3) · Dr. Reddy's Laboratories Limited (2) · Eisai Korea Inc. (2) · Teva Pharmaceuticals USA (2) · Alliance for Clinical Trials in Oncology (1) · Baylor College of Medicine (1) · Central South University (1) · Dong-A ST Co., Ltd. (1) · Eisai Limited (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Merck Sharp & Dohme LLC (1) · NYU Langone Health (1)
United States (21) · Japan (9) · China (4) · South Korea (4) · Australia (3) · Canada (2) · France (2) · India (2) · Netherlands (2) · United Kingdom (2) · Argentina (1) · Chile (1) · Germany (1) · Ireland (1) · Spain (1)
Anita Murthy (2) · Dr. L Krishna Murthy (2) · Hiroki Shimizu (2) · James D Carlson, Pharm.D. (2) · Kazuhiro Omata (2) · Thomas McRae, MD (2) · Allan L Reiss (1) · Aminah Jatoi, MD (1) · Angelle Sander, PhD (1) · David Arciniegas, MD (1) · Edward G. Shaw, MD (1) · Flora Hammond, MD (1) · Holly Posner (1) · Honglan Li, Ph.D. (1) · Itaru Arimoto (1)
PMID 15480814, PMID 16549835, PMID 20678673, PMID 21612646, PMID 21689411, PMID 22572767, PMID 22930699, PMID 24073978, PMID 29635383, PMID 36910501, PMID 41910461
U10CA081851 (3), P01HD024448 (1)